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Tfe3 Gene Detail
Summary
  • Symbol
    Tfe3
  • Name
    transcription factor E3
  • Synonyms
    bHLHe33, F830016E06Rik, Tcfe3, Tfe3, Tfe-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98511
    NCBI Gene: 209446
  • Gene Overview
    MyGene.info: TFE3
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7762560-7775202 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.50 cM, cytoband A2
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98511
protein coding gene ChrX:7762537-7775202 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035523
protein coding gene ChrX:2380145-2392787 (+)
A/J MGP_AJ_G0035501
protein coding gene ChrX:2341917-2354744 (+)
AKR/J MGP_AKRJ_G0035433
protein coding gene ChrX:2461296-2473935 (+)
BALB/cJ MGP_BALBcJ_G0035497
protein coding gene ChrX:2364749-2378191 (+)
C3H/HeJ MGP_C3HHeJ_G0035205
protein coding gene ChrX:2430168-2442809 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036021
protein coding gene ChrX:2466038-2478678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032897
protein coding gene ChrX:1907207-1919930 (+)
CAST/EiJ MGP_CASTEiJ_G0034506
protein coding gene ChrX:2319395-2331946 (+)
CBA/J MGP_CBAJ_G0035175
protein coding gene ChrX:2587208-2599849 (+)
DBA/2J MGP_DBA2J_G0035332
protein coding gene ChrX:2366652-2379194 (+)
FVB/NJ MGP_FVBNJ_G0035279
protein coding gene ChrX:2329002-2341644 (+)
LP/J MGP_LPJ_G0035410
protein coding gene ChrX:2401184-2413826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035319
protein coding gene ChrX:2560316-2572956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036039
protein coding gene ChrX:2366845-2379489 (+)
PWK/PhJ MGP_PWKPhJ_G0034207
protein coding gene ChrX:2298417-2311079 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034045
protein coding gene ChrX:2345374-2358015 (+)
WSB/EiJ MGP_WSBEiJ_G0034629
protein coding gene ChrX:2374883-2387523 (+)



Homology
more
  • Human Ortholog
    TFE3, transcription factor binding to IGHM enhancer 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TFE3, transcription factor binding to IGHM enhancer 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe33, RCCP2, RCCX1, TFEA
  • Links
    NCBI Gene ID: 7030
    neXtProt AC: NX_P19532
    UniProt: P19532

  • Chr Location
    Xp11.23; chrX:49028726-49043517 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TFE3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozygous for a knock-out allele are viable and fertile, normally pigmented, have normal eyes and mast cells, and show no evidence of osteopetrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000134 Ensembl Gene Model | MGI Sequence Detail 12643 C57BL/6J ±  kb
transcript ENSMUST00000077680 Ensembl | MGI Sequence Detail 3277 Not Applicable  
polypeptide ENSMUSP00000076864 Ensembl | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    Genomic 5
    cDNA 103
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14763, MGD-MRK-15044, MGD-MRK-15045, MGI:2147926
References
more
  • Summaries
    All 81
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:29571 Roman C, et al., A dominant negative form of transcription activator mTFE3 created by differential splicing. Science. 1991 Oct 4;254(5028):94-7
  • Latest
    J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory