About   Help   FAQ
Tfe3 Gene Detail
Summary
  • Symbol
    Tfe3
  • Name
    transcription factor E3
  • Synonyms
    bHLHe33, F830016E06Rik, Tcfe3, Tfe3, Tfe-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98511
    NCBI Gene: 209446
  • Gene Overview
    MyGene.info: TFE3
Location & Maps
more
  • Genetic Map
    Chromosome X, 3.50 cM, cytoband A2
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    TFE3, transcription factor binding to IGHM enhancer 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TFE3, transcription factor binding to IGHM enhancer 3
    Orthology source: HomoloGene
  • Synonyms
    bHLHe33, RCCP2, RCCX1, TFEA
  • Links
    NCBI Gene ID: 7030
    neXtProt AC: NX_P19532

  • Chr Location
    Xp11.22; chrX:49028726-49043517 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TFE3 associations

Human Disease Mouse Models
       Renal Cell Carcinoma, Xp11-Associated; RCCX1   OMIM: 300854
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    45
  • Gene trapped
    41
  • Targeted
    4
Mice homozygous for a knock-out allele are viable and fertile, normally pigmented, have normal eyes and mast cells, and show no evidence of osteopetrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017822 VEGA Gene Model | MGI Sequence Detail 12643 C57BL/6J ±  kb
transcript OTTMUST00000043162 VEGA | MGI Sequence Detail 3277 Not Applicable  
polypeptide OTTMUSP00000019420 VEGA | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    69 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000016271 transcription factor E3
  • InterPro Domains
    IPR021802 MiT/TFE transcription factors, C-terminal
    IPR031867 MiT/TFE transcription factors, N-terminal
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR024100 Transcription factor E3
Molecular
Reagents
less
  • All nucleic 114
    Genomic 5
    cDNA 102
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14763, MGD-MRK-15044, MGD-MRK-15045, MGI:2147926
References
more
  • Summaries
    All 69
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:29571 Roman C, et al., A dominant negative form of transcription activator mTFE3 created by differential splicing. Science. 1991 Oct 4;254(5028):94-7
  • Latest
    J:219587 Geula S, et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory