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Tfe3
Gene Detail
 Symbol
Name
ID
Tfe3
transcription factor E3
MGI:98511
Synonyms bHLHe33, F830016E06Rik, Tcfe3, Tfe3, Tfe-3
Feature Type protein coding gene
Genetic Map
Chromosome X
3.50 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
ChrX:7762560-7775202 bp, + strand
From VEGA annotation of GRCm38

  12643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Tfe3

Human
homologs
Human Homolog TFE3, transcription factor binding to IGHM enhancer 3
NCBI Gene ID 7030
neXtProt AC  NX_P19532
Human Synonyms  bHLHe33, RCCP2, RCCX1, TFEA
Human Chr (Location)  Xp11.22; chrX:49028726-49043517 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TFE3
Alleles
and
phenotypes
All alleles(45) : Gene trapped(41) Targeted(4)
 
Mice homozygous for a knock-out allele are viable and fertile, normally pigmented, have normal eyes and mast cells, and show no evidence of osteopetrosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process humoral immune response, immune system process, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (262)    Tissues (237)    Images (11)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 231
Northern blot 2
RT-PCR 29
cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(114) Genomic(5) cDNA(102) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017822 (Evidence)
Ensembl Gene ModelENSMUSG00000000134 (Evidence)
Entrez Gene209446 (Evidence)
UniGene249142
DFCITC1572280, TC1592371, TC1681594, TC1698739
DoTSDT.101186649, DT.101230917, DT.101261138, DT.101341724, DT.101356725, DT.101397757, DT.111030418, DT.491000, DT.91596649, DT.99859903
NIA Mouse Gene IndexU019667
Consensus CDS ProjectCCDS52984.1, CCDS52985.1, CCDS72332.1, CCDS72333.1
International Mouse Knockout Project StatusTfe3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017822 VEGA Gene Model | MGI Sequence Detail 12643 C57BL/6J ±  kb
transcript OTTMUST00000043162 VEGA | MGI Sequence Detail 3277 Not Applicable 
polypeptide OTTMUSP00000019420 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(129) RefSeq(19) UniProt(7)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024097 Basic helix-loop-helix leucine zipper transcription factor
InterPro IPR021802 Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR024100 Transcription factor E3
Protein Ontology PR:000016271 transcription factor E3
References (Earliest) J:29571 Roman C, et al., A dominant negative form of transcription activator mTFE3 created by differential splicing. Science. 1991 Oct 4;254(5028):94-7
(Latest) J:203287 Fujimoto Y, et al., TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology. 2013 Oct;154(10):3577-88
All references(74)
Other
accession IDs
MGD-MRK-14763, MGD-MRK-15044, MGD-MRK-15045, MGI:2147926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory