Tfe3
Gene Detail

Symbol Name ID

Tfe3 transcription factor E3 MGI:98511

Synonyms

bHLHe33, F830016E06Rik, Tcfe3, Tfe3, Tfe-3

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.50 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

ChrX:7762560-7775202 bp, + strand From VEGA annotation of GRCm38   12643 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Tfe3

Human homologs

Human Homolog		TFE3, transcription factor binding to IGHM enhancer 3
NCBI Gene ID		7030
neXtProt AC		NX_P19532
Human Synonyms		bHLHe33, RCCP2, RCCX1, TFEA
Human Chr (Location)		Xp11.22; chrX:48886242-48900990 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TFE3

Alleles and phenotypes

All alleles(45) : Targeted(4) Gene trapped(41)
 

Mice homozygous for a knock-out allele are viable and fertile, normally pigmented, have normal eyes and mast cells, and show no evidence of osteopetrosis.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	humoral immune response, positive regulation of cell adhesion, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (213)    Tissues (187)    Images (9)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	182
Northern blot	2
RT-PCR	29

cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(117) Genomic(5) cDNA(105) Primer pair(5) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017822 (Evidence)
Ensembl Gene Model	ENSMUSG00000000134 (Evidence)
Entrez Gene	209446 (Evidence)
UniGene	249142
DFCI	TC1572280, TC1592371, TC1681594, TC1698739
DoTS	DT.101186649, DT.101230917, DT.101261138, DT.101341724, DT.101356725, DT.101397757, DT.111030418, DT.491000, DT.91596649, DT.99859903
NIA Mouse Gene Index	U019667
Consensus CDS Project	CCDS52984.1, CCDS52985.1
International Mouse Knockout Project Status	Tfe3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017822	VEGA Gene Model | MGI Sequence Detail	12643	C57BL/6J
transcript	OTTMUST00000043162	VEGA | MGI Sequence Detail	3277	Not Applicable
polypeptide	OTTMUSP00000019420	VEGA | MGI Sequence Detail	572	Not Applicable

All sequences(122) RefSeq(12) UniProt(7)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024097	Basic helix-loop-helix leucine zipper transcription factor
InterPro	IPR021802	Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR024100	Transcription factor E3
Protein Ontology	PR:000016271	transcription factor E3

References

(Earliest) J:29571 Roman C, et al., A dominant negative form of transcription activator mTFE3 created by differential splicing. Science. 1991 Oct 4;254(5028):94-7
(Latest) J:184629 Iwasaki H, et al., TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2012 Apr;302(7):E896-902
All references(70)

Other accession IDs

MGD-MRK-14763, MGD-MRK-15044, MGD-MRK-15045, MGI:2147926