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Hnf1b
Gene Detail
 Symbol
Name
ID
Hnf1b
HNF1 homeobox B
MGI:98505
STS D11Pas3
Synonyms hepatocyte nuclear factor-1 beta, Hnf1beta, HNF-1Beta, LFB3, Tcf2, Tcf-2, vHNF1
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:83850063-83905819 bp, + strand
From VEGA annotation of GRCm38

  55757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor HNF-1
Gene Tree: Hnf1b

Human
homologs
Human Homolog HNF1B, HNF1 homeobox B
NCBI Gene ID 6928
neXtProt AC  NX_P35680
Human Synonyms  FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LFB3, LF-B3, MODY5, TCF2, TCF-2, VHNF1
Human Chr (Location)  17q12; chr17:37686431-37745105 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human HNF1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit reduced size, impaired development of extraembryonic membranes, lack of visceral or parietal endoderm, and early post-implantation lethality.
 
Interactions
Hnf1b interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process anterior/posterior pattern specification, branching morphogenesis of an epithelial tube, ...
Component cell, nucleus, ...
Function core promoter proximal region DNA binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (509)    Tissues (321)    Images (137)
Theiler Stages: 2, 3, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 334
In situ reporter (knock in) 59
RT-PCR 84
RNase protection 4
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(44) Primer pair(10) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000988 (Evidence)
Ensembl Gene ModelENSMUSG00000020679 (Evidence)
Entrez Gene21410 (Evidence)
UniGene7226
DFCITC1582907, TC1598459
DoTSDT.481162, DT.94263493, DT.97362485
NIA Mouse Gene IndexU013097
Consensus CDS ProjectCCDS25179.1, CCDS70271.1, CCDS70272.1
International Mouse Knockout Project StatusHnf1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000988 VEGA Gene Model | MGI Sequence Detail 55757 C57BL/6J ±  kb
transcript OTTMUST00000001941 VEGA | MGI Sequence Detail 2759 Not Applicable 
polypeptide OTTMUSP00000000936 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminal
InterPro IPR023219 Hepatocyte nuclear factor 1, dimerisation domain
InterPro IPR006899 Hepatocyte nuclear factor 1, N-terminal
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
Protein Ontology PR:000008653 hepatocyte nuclear factor 1-beta
References (Earliest) J:1977 Ott MO, et al., vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech Dev. 1991 Dec;36(1-2):47-58
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(140)
Other
accession IDs
MGD-MRK-14748, MGD-MRK-14754, MGI:2144141, MGI:2144334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory