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Tbxas1
Gene Detail
 Symbol
Name
ID
Tbxas1
thromboxane A synthase 1, platelet
MGI:98497
Synonyms CYP5, CYP5A1, TXAS, TXS
Feature Type protein coding gene
Genetic Map
Chromosome 6
17.85 cM, cytoband F1-pter
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:38875404-39084585 bp, + strand
From VEGA annotation of GRCm38

  209182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP3A5
Gene Tree: Tbxas1

Human
homologs
Human Homolog TBXAS1, thromboxane A synthase 1 (platelet)
NCBI Gene ID 6916
neXtProt AC  NX_P24557
Human Synonyms  BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
Human Chr (Location)  7q34-q35; chr7:139778248-140020325 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TBXAS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased bleeding time and decreased platelet response to arachidonic acid.
 
Interactions
Tbxas1 interacts with 98 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular chloride ion homeostasis, fatty acid biosynthetic process, ...
Component cell, endoplasmic reticulum, ...
Function heme binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (108)    Tissues (107)    Images (2)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 14
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(11) cDNA(30) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034254 (Evidence)
Ensembl Gene ModelENSMUSG00000029925 (Evidence)
Entrez Gene21391 (Evidence)
UniGene4054
DFCITC1582679
DoTSDT.40158754, DT.91363811, DT.94295817
NIA Mouse Gene IndexU006696
EC5.3.99.5
Consensus CDS ProjectCCDS20018.1
International Mouse Knockout Project StatusTbxas1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034254 VEGA Gene Model | MGI Sequence Detail 209182 C57BL/6J ±  kb
transcript OTTMUST00000087034 VEGA | MGI Sequence Detail 1990 Not Applicable 
polypeptide OTTMUSP00000047189 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(20) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(834 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000016155 thromboxane-A synthase
References (Earliest) J:13301 Zhang L, et al., Molecular cloning and expression of murine thromboxane synthase. Biochem Biophys Res Commun. 1993 Jul 30;194(2):741-8
(Latest) J:203820 Matsunobu T, et al., Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. J Lipid Res. 2013 Nov;54(11):2979-87
All references(37)
Other
accession IDs
MGD-MRK-14734

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory