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Tbxas1 Gene Detail
Summary
  • Symbol
    Tbxas1
  • Name
    thromboxane A synthase 1, platelet
  • Synonyms
    CYP5, CYP5A1, TXAS, TXS
  • Feature Type
    protein coding gene
  • IDs
    MGI:98497
    NCBI Gene: 21391
  • Gene Overview
    MyGene.info: TBXAS1
Location & Maps
more
  • Sequence Map
    Chr6:38875404-39084585 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      209182 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 17.85 cM, cytoband F1-pter
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TBXAS1, thromboxane A synthase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TBXAS1, thromboxane A synthase 1
    Orthology source: HomoloGene
  • Synonyms
    BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
  • Links
    NCBI Gene ID: 6916
    neXtProt AC: NX_P24557

  • Chr Location
    7q34-q35; chr7:139778248-140020325 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human TBXAS1 associations

Human Disease Mouse Models
       Bleeding Disorder, Platelet-Type, 14; BDPLT14   OMIM: 614158
Ghosal Hematodiaphyseal Dysplasia; GHDD   OMIM: 231095
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased bleeding time and decreased platelet response to arachidonic acid.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034254 VEGA Gene Model | MGI Sequence Detail 209182 C57BL/6J ±  kb
transcript OTTMUST00000087034 VEGA | MGI Sequence Detail 1990 Not Applicable  
polypeptide OTTMUSP00000047189 VEGA | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    847 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 11
    cDNA 30
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14734
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:13301 Zhang L, et al., Molecular cloning and expression of murine thromboxane synthase. Biochem Biophys Res Commun. 1993 Jul 30;194(2):741-8
  • Latest
    J:213738 Liu M, et al., 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med. 2014 Jun 2;211(6):1063-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory