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Tbxas1 Gene Detail
Summary
  • Symbol
    Tbxas1
  • Name
    thromboxane A synthase 1, platelet
  • Synonyms
    CYP5, CYP5A1, TXAS, TXS
  • Feature Type
    protein coding gene
  • IDs
    MGI:98497
    NCBI Gene: 21391
  • Gene Overview
    MyGene.info: TBXAS1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:38875404-39084585 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 17.85 cM, cytoband F1-pter
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    847 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98497
protein coding gene Chr6:38875377-39084590 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030592
protein coding gene Chr6:37218559-37437842 (+)
A/J MGP_AJ_G0030565
protein coding gene Chr6:35592436-35803791 (+)
AKR/J MGP_AKRJ_G0030492
protein coding gene Chr6:36733046-36947605 (+)
BALB/cJ MGP_BALBcJ_G0030575
protein coding gene Chr6:35806907-36018262 (+)
C3H/HeJ MGP_C3HHeJ_G0030288
protein coding gene Chr6:36740821-36954839 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031029
protein coding gene Chr6:38137937-38357043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028241
protein coding gene Chr6:33497934-33710058 (+)
CAST/EiJ MGP_CASTEiJ_G0029690
protein coding gene Chr6:36640834-36858054 (+)
CBA/J MGP_CBAJ_G0030266
protein coding gene Chr6:39632183-39861655 (+)
DBA/2J MGP_DBA2J_G0030410
protein coding gene Chr6:35411386-35632759 (+)
FVB/NJ MGP_FVBNJ_G0030364
protein coding gene Chr6:35202109-35412477 (+)
LP/J MGP_LPJ_G0030497
protein coding gene Chr6:37248864-37465396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030400
protein coding gene Chr6:42013052-42231670 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031059
protein coding gene Chr6:36661592-36878333 (+)
PWK/PhJ MGP_PWKPhJ_G0029404
protein coding gene Chr6:35085763-35303680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029240
protein coding gene Chr6:36384081-36618835 (+)
WSB/EiJ MGP_WSBEiJ_G0029766
protein coding gene Chr6:36605387-36827388 (+)



Homology
more
  • Human Ortholog
    TBXAS1, thromboxane A synthase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TBXAS1, thromboxane A synthase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
  • Links
    NCBI Gene ID: 6916
    neXtProt AC: NX_P24557
    UniProt: P24557

  • Chr Location
    7q34; chr7:139778248-140020325 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TBXAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased bleeding time and decreased platelet response to arachidonic acid.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029925 Ensembl Gene Model | MGI Sequence Detail 209182 C57BL/6J ±  kb
transcript ENSMUST00000003017 Ensembl | MGI Sequence Detail 1990 Not Applicable  
polypeptide ENSMUSP00000003017 Ensembl | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 11
    cDNA 31
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14734
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:13301 Zhang L, et al., Molecular cloning and expression of murine thromboxane synthase. Biochem Biophys Res Commun. 1993 Jul 30;194(2):741-8
  • Latest
    J:248893 Pai CH, et al., Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. PLoS One. 2016;11(3):e0151617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory