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Tbxa2r
Gene Detail
Symbol

Name
ID
Tbxa2r
thromboxane A2 receptor
MGI:98496
Synonyms
TP, Tp receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:81328732-81335171 bp, + strand
From Ensembl annotation of GRCm38

  6440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Tbxa2r

Human
homologs
Human Homolog TBXA2R, thromboxane A2 receptor
NCBI Gene ID 6915
neXtProt AC  NX_P21731
Human Synonyms  BDPLT13, TXA2-R
Human Chr (Location)  19p13.3; chr19:3594506-3606833 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TBXA2R
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy.
 
Interactions
Tbxa2r interacts with 64 markers (Mir27a, Mir27b, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process G-protein coupled receptor signaling pathway, inflammatory response, ...
Component acrosomal vesicle, cytosol, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034881 (Evidence)
Entrez Gene21390 (Evidence)
UniGene4545
DFCITC1595009, TC1622759
DoTSDT.101306517, DT.485026
NIA Mouse Gene IndexU011781
Consensus CDS ProjectCCDS24053.1
International Mouse Knockout Project StatusTbxa2r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034881 Ensembl Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
transcript ENSMUST00000105325 Ensembl | MGI Sequence Detail 1763 Not Applicable 
polypeptide ENSMUSP00000100962 Ensembl | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR008365 Prostanoid receptor
InterPro IPR001105 Thromboxane receptor
Protein Ontology PR:000001676 thromboxane A2 receptor
References
(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:213738 Liu M, et al., 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med. 2014 Jun 2;211(6):1063-78
All references(76)
Other
accession IDs
MGD-MRK-14733

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory