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Tbxa2r Gene Detail
Summary
  • Symbol
    Tbxa2r
  • Name
    thromboxane A2 receptor
  • Synonyms
    TP, Tp receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:98496
    NCBI Gene: 21390
  • Gene Overview
    MyGene.info: TBXA2R
Location & Maps
more
  • Sequence Map
    Chr10:81328732-81335171 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6440 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TBXA2R, thromboxane A2 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TBXA2R, thromboxane A2 receptor
    Orthology source: HomoloGene
  • Synonyms
    BDPLT13, TXA2-R
  • Links
    NCBI Gene ID: 6915
    neXtProt AC: NX_P21731

  • Chr Location
    19p13.3; chr19:3594506-3606851 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TBXA2R associations

Human Disease Mouse Models
       Bleeding Disorder, Platelet-Type, 13, Susceptibility To; BDPLT13   OMIM: 614009
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Tbxa2r
  • Incidental Mutations
Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034881 Ensembl Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
transcript ENSMUST00000105325 Ensembl | MGI Sequence Detail 1763 Not Applicable  
polypeptide ENSMUSP00000100962 Ensembl | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14733
References
more
  • Summaries
    All 73
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 45
  • Earliest
    J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
  • Latest
    J:222924 Ma X, et al., Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. Cancer Res. 2015 Jul 15;75(14):2822-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory