Tbxa2r
Gene Detail

Symbol Name ID

Tbxa2r thromboxane A2 receptor MGI:98496

Synonyms

TP, Tp receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:81328732-81335171 bp, + strand From Ensembl annotation of GRCm38   6440 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:825  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Tbxa2r

Human homologs

Human Homolog		TBXA2R, thromboxane A2 receptor
NCBI Gene ID		6915
neXtProt AC		NX_P21731
Human Synonyms		BDPLT13, TXA2-R
Human Chr (Location)		19p13.3; chr19:3594504-3606831 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TBXA2R

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	acrosomal vesicle, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034881 (Evidence)
Entrez Gene	21390 (Evidence)
UniGene	4545
DFCI	TC1595009, TC1622759
DoTS	DT.101306517, DT.485026
NIA Mouse Gene Index	U011781
Consensus CDS Project	CCDS24053.1
International Mouse Knockout Project Status	Tbxa2r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000034881	Ensembl Gene Model | MGI Sequence Detail	6440	C57BL/6J
transcript	ENSMUST00000105325	Ensembl | MGI Sequence Detail	1763	Not Applicable
polypeptide	ENSMUSP00000100962	Ensembl | MGI Sequence Detail	341	Not Applicable

All sequences(22) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR008365	Prostanoid receptor
InterPro	IPR001105	Thromboxane receptor
Protein Ontology	PR:000001676	thromboxane A2 receptor

References

(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:192201 Niu H, et al., Integrin alphaIIb-mediated PI3K/Akt activation in platelets. PLoS One. 2012;7(10):e47356
All references(69)

Other accession IDs

MGD-MRK-14733