Tbx2 MGI Mouse Gene Detail - MGI:98494

Tbx2 Gene Detail

Symbol

Tbx2
Name

T-box 2

Feature Type

protein coding gene
IDs

MGI:98494
NCBI Gene: 21385
Gene Overview

MyGene.info: TBX2

Sequence Map

Chr11:85832551-85841948 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

9398 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.34 cM
Mapping Data

5 experiments

Human Ortholog

TBX2, T-box 2

Vertebrate Orthologs

10

Human Ortholog

TBX2, T-box 2
Orthology source: HomoloGene, HGNC
Links

HGNC:11597

NCBI Gene ID: 6909

neXtProt AC: NX_Q13207
Chr Location

17q23.2; chr17:61394698-61409466 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 38123
1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TBX2
Protein SuperFamily

transcription factor Tbx2
Gene Tree

Tbx2

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Phenotype Summary

19 phenotypes from 4 alleles in 6 genetic backgrounds
6 phenotypes from multigenic genotypes
1 images
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Targeted

9
Genomic Mutations

2 involving Tbx2

Homozygous null mice display embryonic lethality with abnormal cardiac and vascular development, edema, and polydactyly.

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All GO Annotations

43
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

442
Tissues

294
cDNA Data

54
Literature Summary

111

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase tbx2

ZFIN tbx2a, tbx2b

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Tbx2 interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

22
RefSeq

2
UniProt

2
CCDS

CCDS36266.1
UniGene

287052

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001028	VEGA Gene Model \| MGI Sequence Detail	9398	C57BL/6J	± kb
transcript	OTTMUST00000002057	VEGA \| MGI Sequence Detail	3626	Not Applicable
polypeptide	OTTMUSP00000000995	VEGA \| MGI Sequence Detail	711	Not Applicable

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SNPs within 2kb

37 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000016148 T-box transcription factor TBX2
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding

IPR002070 Transcription factor, Brachyury

IPR001699 Transcription factor, T-box

IPR018186 Transcription factor, T-box, conserved site

IPR022582 Transcription factor, T-box, region of unknown function

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All nucleic 71

Genomic 4

cDNA 55

Primer pair 3

Other 9

Microarray probesets 5

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MGD-MRK-14731

Summaries

All 153

Developmental Gene Expression 111

Gene Ontology 12

Phenotypes 29
Earliest

J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
Latest

J:229902 Gaston-Massuet C, et al., Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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