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Tbx2 Gene Detail
Summary
  • Symbol
    Tbx2
  • Name
    T-box 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98494
    NCBI Gene: 21385
  • Gene Overview
    MyGene.info: TBX2
Location & Maps
more
  • Sequence Map
    Chr11:85832551-85841948 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9398 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TBX2, T-box 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBX2, T-box 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6909
    neXtProt AC: NX_Q13207
    UniProt: Q13207

  • Chr Location
    17q23.2; chr17:61399896-61409466 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with abnormal cardiac and vascular development, edema, and polydactyly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    478
  • Tissues
    311
  • cDNA Data
    55
  • Literature Summary
    115
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001028 VEGA Gene Model | MGI Sequence Detail 9398 C57BL/6J ±  kb
transcript OTTMUST00000002057 VEGA | MGI Sequence Detail 3626 Not Applicable  
polypeptide OTTMUSP00000000995 VEGA | MGI Sequence Detail 711 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016148 T-box transcription factor TBX2
    (term hierarchy)
  • InterPro Domains
    IPR008967 p53-like transcription factor, DNA-binding
    IPR002070 Transcription factor, Brachyury
    IPR001699 Transcription factor, T-box
    IPR018186 Transcription factor, T-box, conserved site
    IPR022582 Transcription factor, T-box, region of unknown function
Molecular
Reagents
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  • All nucleic 74
    Genomic 4
    cDNA 56
    Primer pair 3
    Other 11

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14731
References
more
  • Summaries
    All 165
    Developmental Gene Expression 115
    Gene Ontology 12
    Phenotypes 29
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:237201 Espinosa-Medina I, et al., The sacral autonomic outflow is sympathetic. Science. 2016 Nov 18;354(6314):893-897
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory