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Tbx2
Gene Detail
 Symbol
Name
ID
Tbx2
T-box 2
MGI:98494
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:85832551-85841948 bp, + strand
From VEGA annotation of GRCm38

  9398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38123  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx2

Human
homologs
Human Homolog TBX2, T-box 2
NCBI Gene ID 6909
neXtProt AC  NX_Q13207
Human Chr (Location)  17q23.2; chr17:61399896-61409466 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Homozygous null mice display embryonic lethality with abnormal cardiac and vascular development, edema, and polydactyly.
 
Phenotype Images(1)
Interactions
Tbx2 interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process aorta morphogenesis, atrioventricular canal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (102 records)
Data Summary: Results (404)    Tissues (270)    Images (109)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 336
Northern blot 12
RT-PCR 52
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) Genomic(4) cDNA(55) Primer pair(3) Other(7)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001028 (Evidence)
Ensembl Gene ModelENSMUSG00000000093 (Evidence)
Entrez Gene21385 (Evidence)
UniGene287052
DFCITC1582816, TC1612609, TC1622302, TC1661933, TC1705150
DoTSDT.50315424, DT.55208893, DT.94357753, DT.94396703
NIA Mouse Gene IndexU013122
Consensus CDS ProjectCCDS36266.1
International Mouse Knockout Project StatusTbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001028 VEGA Gene Model | MGI Sequence Detail 9398 C57BL/6J ±  kb
transcript OTTMUST00000002057 VEGA | MGI Sequence Detail 3626 Not Applicable 
polypeptide OTTMUSP00000000995 VEGA | MGI Sequence Detail 711 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR002070 Transcription factor, Brachyury
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
InterPro IPR022582 Transcription factor, T-box, region of unknown function
Protein Ontology PR:000016148 T-box transcription factor TBX2
References (Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(147)
Other
accession IDs
MGD-MRK-14731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory