Tbx2
Gene Detail

Symbol

Name
ID

Tbx2
T-box 2
MGI:98494

Feature Type

protein coding gene

Genetic Map

Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:85832551-85841948 bp, + strand From VEGA annotation of GRCm38   9398 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:38123  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: transcription factor Tbx2
Gene Tree: Tbx2

Human
homologs

Human Homolog		TBX2, T-box 2
NCBI Gene ID		6909
neXtProt AC		NX_Q13207
Human Chr (Location)		17q23.2; chr17:61399896-61409466 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Tbx2 (1)
 

Homozygous null mice display embryonic lethality with abnormal cardiac and vascular development, edema, and polydactyly.

 
Phenotype Images(1)

Interactions

Tbx2 interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (43 annotations)

Process	aorta morphogenesis, atrioventricular canal development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (107 records)

Data Summary: Results (442)    Tissues (294)    Images (137)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	5
RNA in situ	373
Northern blot	12
RT-PCR	52

cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(71) Genomic(4) cDNA(55) Primer pair(3) Other(9)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000001028 (Evidence)
Ensembl Gene Model	ENSMUSG00000000093 (Evidence)
Entrez Gene	21385 (Evidence)
UniGene	287052
DFCI	TC1582816, TC1612609, TC1622302, TC1661933, TC1705150
DoTS	DT.50315424, DT.55208893, DT.94357753, DT.94396703
NIA Mouse Gene Index	U013122
Consensus CDS Project	CCDS36266.1
International Mouse Knockout Project Status	Tbx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001028	VEGA Gene Model | MGI Sequence Detail	9398	C57BL/6J
transcript	OTTMUST00000002057	VEGA | MGI Sequence Detail	3626	Not Applicable
polypeptide	OTTMUSP00000000995	VEGA | MGI Sequence Detail	711	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(37 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR002070	Transcription factor, Brachyury
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
InterPro	IPR022582	Transcription factor, T-box, region of unknown function
Protein Ontology	PR:000016148	T-box transcription factor TBX2

References

(Earliest) J:864 Namba T, et al., Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203
(Latest) J:213620 Kong P, et al., Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
All references(153)

Other
accession IDs

MGD-MRK-14731