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Tat Gene Detail
Summary
  • Symbol
    Tat
  • Name
    tyrosine aminotransferase
  • Synonyms
    MGC:37772, MGC:37789, MGC:37790, MGC:37819, MGC:37828, MGC:37842
  • Feature Type
    protein coding gene
  • IDs
    MGI:98487
    NCBI Gene: 234724
Location & Maps
more
  • Sequence Map
    Chr8:109990437-109999803 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9367 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TAT, tyrosine aminotransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAT, tyrosine aminotransferase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 6898
    neXtProt AC: NX_P17735

  • Chr Location
    16q22.1; chr16:71566851-71577095 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TAT associations

Human Disease Mouse Models
       Tyrosinemia, Type II; TYRSN2   OMIM: 276600
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026257 VEGA Gene Model | MGI Sequence Detail 9367 C57BL/6J ±  kb
transcript OTTMUST00000064935 VEGA | MGI Sequence Detail 2375 Not Applicable  
polypeptide OTTMUSP00000032296 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016089 tyrosine aminotransferase
  • PDB
  • EC
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
    IPR005957 Tyrosine aminotransferase
    IPR011715 Tyrosine aminotransferase ubiquitination region
    IPR005958 Tyrosine/nicotianamine aminotransferase
Molecular
Reagents
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  • All nucleic 133
    Genomic 9
    cDNA 119
    Primer pair 3
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-14719
References
more
  • Summaries
    All 63
    Developmental Gene Expression 18
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:25840 Blake RL, Regulation of liver tyrosine aminotransferase activity in inbred strains and mutant mice, I. Strain variance in fasting enzyme levels. Int J Biochem. 1970;1:361-70
  • Latest
    J:226930 Yanagida A, et al., Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner. Dev Biol. 2015 Nov 15;407(2):331-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory