Tat
Gene Detail

Symbol Name ID

Tat tyrosine aminotransferase MGI:98487

Synonyms

MGC:37772, MGC:37789, MGC:37790, MGC:37819, MGC:37828, MGC:37842

Feature Type

protein coding gene

Genetic Map

Chromosome 8

57.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr8:109990437-109999803 bp, + strand From VEGA annotation of GRCm38   9367 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine transaminase
Gene Tree: Tat

Human homologs

Human Homolog		TAT, tyrosine aminotransferase
NCBI Gene ID		6898
neXtProt AC		NX_P17735
Human Chr (Location)		16q22.1; chr16:71600754-71610998 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TAT

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	2-oxoglutarate metabolic process, aromatic amino acid family catabolic process, ...
Component	mitochondrion
Function	amino acid binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (130)    Tissues (99)    Images (1)
Theiler Stages: 20, 22, 24, 25, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	30
RT-PCR	6

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(132) Genomic(9) cDNA(119) Primer pair(2) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000026257 (Evidence)
Ensembl Gene Model	ENSMUSG00000001670 (Evidence)
Entrez Gene	234724 (Evidence)
UniGene	28110
DFCI	TC1576826
DoTS	DT.494658
NIA Mouse Gene Index	U009814
EC	2.6.1.5
PDB	3PDX
Consensus CDS Project	CCDS22658.1
International Mouse Knockout Project Status	Tat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026257	VEGA Gene Model | MGI Sequence Detail	9367	C57BL/6J
transcript	OTTMUST00000064935	VEGA | MGI Sequence Detail	2375	Not Applicable
polypeptide	OTTMUSP00000032296	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004839	Aminotransferase, class I/classII
InterPro	IPR004838	Aminotransferases, class-I, pyridoxal-phosphate-binding site
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro	IPR005957	Tyrosine aminotransferase
InterPro	IPR011715	Tyrosine aminotransferase ubiquitination region
InterPro	IPR005958	Tyrosine/nicotianamine aminotransferase
InterPro	IPR021178	Tyrosine transaminase
Protein Ontology	PR:000016089	tyrosine aminotransferase

References

(Earliest) J:25840 Blake RL, Regulation of liver tyrosine aminotransferase activity in inbred strains and mutant mice, I. Strain variance in fasting enzyme levels. Int J Biochem. 1970;1:361-70
(Latest) J:178360 Zhang M, et al., Disruption of beta-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice. Mech Dev. 2011 Sep;128(7-10):368-75
All references(67)

Other accession IDs

MGD-MRK-14719