Tacr2
Gene Detail

Symbol Name ID

Tacr2 tachykinin receptor 2 MGI:98477

Synonyms

Tac2r

Feature Type

protein coding gene

Genetic Map

Chromosome 10

32.37 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:62252438-62265990 bp, + strand From NCBI annotation of GRCm38   13553 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55548  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tachykinin receptor
Gene Tree: Tacr2

Human homologs

Human Homolog		TACR2, tachykinin receptor 2
NCBI Gene ID		6865
neXtProt AC		NX_P21452
Human Synonyms		NK2R, NKNAR, SKR, TAC2R
Human Chr (Location)		10q22.1; chr10:71163958-71176674 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	G-protein coupled receptor signaling pathway, signal transduction
Component	cell, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (18)    Images (3)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	24
RT-PCR	3

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(3) cDNA(7) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000020081 (Evidence)
Entrez Gene	21337 (Evidence)
UniGene	8054
DFCI	TC1590287
DoTS	DT.91328073
NIA Mouse Gene Index	U011577
Consensus CDS Project	CCDS35919.1
International Mouse Knockout Project Status	Tacr2

Sequences

Length	Strain/Species
genomic	21337	NCBI Gene Model | MGI Sequence Detail	13553	C57BL/6J
transcript	NM_009314	RefSeq | MGI Sequence Detail	2258	C57BL/6
polypeptide	P30549	UniProt | EBI | MGI Sequence Detail	384	Not Applicable

All sequences(16) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR000913	Neurokinin NK2 receptor
InterPro	IPR001681	Neurokinin receptor
Protein Ontology	PR:000001246	substance-K receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
(Latest) J:188444 Kitamura H, et al., Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor. J Immunol. 2012 May 1;188(9):4200-8
All references(31)

Other accession IDs

MGD-MRK-14704