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Tac2
Gene Detail
Symbol

Name
ID
Tac2
tachykinin 2
MGI:98476
Synonyms
neurokinin 2, neurokinin A, neurokinin alpha, neuromedin L, neuropeptide K, substance K
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.81 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:127724478-127731767 bp, + strand
From Ensembl annotation of GRCm38

  7290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TAC3
Protein SuperFamily: neurokinin B
Gene Tree: Tac2

Human
homologs
TAC3, tachykinin 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6866
neXtProt AC: NX_Q9UHF0

Human Synonyms: HH10, NKB, NKNB, PRO1155, ZNEUROK1

Human Chr (Location): 12q13.3; chr12:57009997-57016560 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TAC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit absence of agonist-induced hyperalgesia and an impaired response to chemical irritation of the urinary tract. Mice homozygous for a different knock-out allele display hypoalgesia, and reduced anxiety- and depression-related behaviors.
 
Interactions
Tac2 interacts with 24 markers (Mir31, Mir139, Mir155, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process neuropeptide signaling pathway, positive regulation of blood pressure, ...
Component extracellular exosome, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (137)    Tissues (69)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 94
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN tac3a, tac3b    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025400 (Evidence)
Entrez Gene 21334 (Evidence)
UniGene 2374
DFCI TC1586509
DoTS DT.101364593, DT.530245
NIA Mouse Gene Index U012158
Consensus CDS Project CCDS24248.1
International Mouse Phenotyping Consortium Status Tac2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025400 Ensembl Gene Model | MGI Sequence Detail 7290 C57BL/6J ±  kb
transcript ENSMUST00000179960 Ensembl | MGI Sequence Detail 852 Not Applicable 
polypeptide ENSMUSP00000136622 Ensembl | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003635 Neurokinin
InterPro IPR013055 Tachykinin/Neurokinin-like, conserved site
Protein Ontology PR:000016004 tachykinin-3
References
(Earliest) J:15584 Kako K, et al., Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin-A and Preprotachykinin-B. Biomed Res. 1993 Aug;14(4):253-259
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(43)
Other
accession IDs
MGD-MRK-14703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory