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Tac2 Gene Detail
Summary
  • Symbol
    Tac2
  • Name
    tachykinin 2
  • Synonyms
    neurokinin 2, neurokinin A, neurokinin alpha, neuromedin L, neuropeptide K, substance K
  • Feature Type
    protein coding gene
  • IDs
    MGI:98476
    NCBI Gene: 21334
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127560347-127567637 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.81 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98476
protein coding gene Chr10:127560347-127567637 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017832
protein coding gene Chr10:131350842-131360279 (+)
A/J MGP_AJ_G0017807
protein coding gene Chr10:126097646-126104919 (+)
AKR/J MGP_AKRJ_G0017770
protein coding gene Chr10:129816436-129823721 (+)
BALB/cJ MGP_BALBcJ_G0017771
protein coding gene Chr10:126497657-126505091 (+)
C3H/HeJ MGP_C3HHeJ_G0017595
protein coding gene Chr10:129972819-129981211 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018226
protein coding gene Chr10:135799932-135808696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015906
protein coding gene Chr10:120079088-120085991 (+)
CAST/EiJ MGP_CASTEiJ_G0017155
protein coding gene Chr10:130639410-130648557 (+)
CBA/J MGP_CBAJ_G0017564
protein coding gene Chr10:141283791-141292620 (+)
DBA/2J MGP_DBA2J_G0017670
protein coding gene Chr10:125169814-125178132 (+)
FVB/NJ MGP_FVBNJ_G0017665
protein coding gene Chr10:124113927-124124009 (+)
LP/J MGP_LPJ_G0017744
protein coding gene Chr10:131926523-131935113 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017693
protein coding gene Chr10:143959634-143968253 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018266
protein coding gene Chr10:129894905-129903536 (+)
PWK/PhJ MGP_PWKPhJ_G0016940
protein coding gene Chr10:125379090-125386428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016732
protein coding gene Chr10:128921833-128929156 (+)
WSB/EiJ MGP_WSBEiJ_G0017216
protein coding gene Chr10:130113773-130122584 (+)



Homology
more
  • Human Ortholog
    TAC3, tachykinin precursor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAC3, tachykinin precursor 3
  • Synonyms
    HH10, LncZBTB39, NK3, NKB, NKNB, PRO1155, ZNEUROK1
  • Links
    NCBI Gene ID: 6866
    neXtProt AC: NX_Q9UHF0
    UniProt: Q9UHF0

  • Chr Location
    12q13.3; chr12:57010000-57028883 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TAC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed female sexual maturation and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21334 NCBI Gene Model | MGI Sequence Detail 7291 C57BL/6J ±  kb
    transcript NM_001199971 RefSeq | MGI Sequence Detail 870 C57BL/6  
    polypeptide P55099 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14703
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 30
    • Earliest
      J:15584 Kako K, et al., Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin-A and Preprotachykinin-B. Biomed Res. 1993 Aug;14(4):253-259
    • Latest
      J:343327 Lee H, et al., Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLoS Biol. 2023 Nov;21(11):e3002386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory