Tac2
Gene Detail

Symbol Name ID

Tac2 tachykinin 2 MGI:98476

Synonyms

neurokinin 2, neurokinin A, neurokinin alpha, neuromedin L, neuropeptide K, substance K

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.81 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:127724478-127731767 bp, + strand From Ensembl annotation of GRCm38   7290 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: neurokinin B
Gene Tree: Tac2

Human homologs

Human Homolog		TAC3, tachykinin 3
NCBI Gene ID		6866
neXtProt AC		NX_Q9UHF0
Human Synonyms		HH10, NKB, NKNB, PRO1155, ZNEUROK1
Human Chr (Location)		12q13-q21; chr12:57403781-57410344 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TAC3

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mice homozygous for a targeted mutation do not exhibit an overt mutant phenotype for any parameter tested.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	neuropeptide signaling pathway, positive regulation of blood pressure, ...
Component	extracellular region

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (137)    Tissues (69)    Images (15)
Theiler Stages: 18, 19, 23, 28

Assay Type	Results
RNA in situ	43
RT-PCR	94

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000025400 (Evidence)
Entrez Gene	21334 (Evidence)
UniGene	2374
DFCI	TC1586509
DoTS	DT.101364593, DT.530245
NIA Mouse Gene Index	U012158
Consensus CDS Project	CCDS24248.1
International Mouse Knockout Project Status	Tac2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025400	Ensembl Gene Model | MGI Sequence Detail	7290	C57BL/6J
transcript	ENSMUST00000179960	Ensembl | MGI Sequence Detail	852	Not Applicable
polypeptide	ENSMUSP00000136622	Ensembl | MGI Sequence Detail	116	Not Applicable

All sequences(20) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003635	Neurokinin
InterPro	IPR013055	Tachykinin/Neurokinin-like, conserved site
Protein Ontology	PR:000016004	tachykinin-3

References

(Earliest) J:15584 Kako K, et al., Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin-A and Preprotachykinin-B. Biomed Res. 1993 Aug;14(4):253-259
(Latest) J:181711 Poling MC, et al., Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012 Feb;153(2):782-93
All references(39)

Other accession IDs

MGD-MRK-14703