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Tac2
Gene Detail
 Symbol
Name
ID
Tac2
tachykinin 2
MGI:98476
Synonyms neurokinin 2, neurokinin A, neurokinin alpha, neuromedin L, neuropeptide K, substance K
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.81 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:127724478-127731767 bp, + strand
From Ensembl annotation of GRCm38

  7290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: neurokinin B
Gene Tree: Tac2

Human
homologs
Human Homolog TAC3, tachykinin 3
NCBI Gene ID 6866
neXtProt AC  NX_Q9UHF0
Human Synonyms  HH10, NKB, NKNB, PRO1155, ZNEUROK1
Human Chr (Location)  12q13-q21; chr12:57009997-57024029 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TAC3
Alleles
and
phenotypes
All alleles(7) : Targeted(5) Gene trapped(2)
 
Mice homozygous for a knock-out allele exhibit absence of agonist-induced hyperalgesia and an impaired response to chemical irritation of the urinary tract. Mice homozygous for a different knock-out allele display hypoalgesia, and reduced anxiety- and depression-related behaviors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process neuropeptide signaling pathway, positive regulation of blood pressure, ...
Component extracellular region
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (137)    Tissues (69)    Images (15)
Theiler Stages: 18, 19, 23, 28
Assay TypeResults
RNA in situ 43
RT-PCR 94
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025400 (Evidence)
Entrez Gene21334 (Evidence)
UniGene2374
DFCITC1586509
DoTSDT.101364593, DT.530245
NIA Mouse Gene IndexU012158
Consensus CDS ProjectCCDS24248.1
International Mouse Knockout Project StatusTac2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025400 Ensembl Gene Model | MGI Sequence Detail 7290 C57BL/6J ±  kb
transcript ENSMUST00000026466 Ensembl | MGI Sequence Detail 680 Not Applicable 
polypeptide ENSMUSP00000026466 Ensembl | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003635 Neurokinin
InterPro IPR013055 Tachykinin/Neurokinin-like, conserved site
Protein Ontology PR:000016004 tachykinin-3
References (Earliest) J:15584 Kako K, et al., Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin-A and Preprotachykinin-B. Biomed Res. 1993 Aug;14(4):253-259
(Latest) J:181711 Poling MC, et al., Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012 Feb;153(2):782-93
All references(40)
Other
accession IDs
MGD-MRK-14703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory