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Tacr1
Gene Detail
Symbol

Name
ID
Tacr1
tachykinin receptor 1
MGI:98475
Synonyms
neurokinin receptor 1, NK-1R, NK1-R, NK1 receptor, SPr, substance p receptor, Tac1r
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:82402475-82560103 bp, + strand
From Ensembl annotation of GRCm38

  157629 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TACR1
Protein SuperFamily: tachykinin receptor
Gene Tree: Tacr1

Human
homologs
TACR1, tachykinin receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6869
neXtProt AC: NX_P25103

Human Synonyms: NK1R, NKIR, SPR, TAC1R

Human Chr (Location): 2p12; chr2:75046463-75199519 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Genomic Mutations involving Tacr1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced anxiety, pain and stress-related responses, reduced immunological response after a viral challenge, and reduced inflammatory responses.
 
Human Diseases Modeled in Mice Using Tacr1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tacr1 interacts with 264 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process aggressive behavior, angiotensin-mediated drinking behavior, ...
Component cell body, cell periphery, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (123)    Tissues (114)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
RT-PCR 5
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tacr1    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030043 (Evidence)
Entrez Gene 21336 (Evidence)
UniGene 8055
DFCI TC1595126, TC1612228, TC1598060
DoTS DT.60102899, DT.101725490
Consensus CDS Project CCDS20262.1
International Mouse Phenotyping Consortium Status Tacr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030043 Ensembl Gene Model | MGI Sequence Detail 157629 C57BL/6J ±  kb
transcript ENSMUST00000032122 Ensembl | MGI Sequence Detail 5025 Not Applicable 
polypeptide ENSMUSP00000032122 Ensembl | MGI Sequence Detail 407 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(1598 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1606)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000046 Neurokinin NK1 receptor
InterPro IPR001681 Neurokinin receptor
Protein Ontology PR:000001247 substance-P receptor
References
(Earliest) J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
(Latest) J:221176 Leal EC, et al., Substance p promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol. 2015 Jun;185(6):1638-48
All references(141)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-14702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory