About   Help   FAQ
Syp
Gene Detail
 Symbol
Name
ID
Syp
synaptophysin
MGI:98467
Synonyms A230093K24Rik, p38, Syn, Syp I
Feature Type protein coding gene
Genetic Map
Chromosome X
3.44 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
ChrX:7638471-7653256 bp, + strand
From VEGA annotation of GRCm38

  14786 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Syp

Human
homologs
Human Homolog SYP, synaptophysin
NCBI Gene ID 6855
neXtProt AC  NX_P08247
Human Synonyms  MRX96, MRXSYP
Human Chr (Location)  Xp11.23-p11.22; chrX:49187812-49200202 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SYP
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
 
Interactions
Syp interacts with 171 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular response to organic substance, endocytosis, ...
Component cell junction, cytoplasmic vesicle, ...
Function cholesterol binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (180 records)
Data Summary: Results (96)    Tissues (55)    Images (19)
Theiler Stages: 16, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 29
Western blot 29
RT-PCR 9
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(12) cDNA(109) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017756 (Evidence)
Ensembl Gene ModelENSMUSG00000031144 (Evidence)
Entrez Gene20977 (Evidence)
UniGene223674
DFCITC1573762, TC1614408, TC1676956, TC1758349
DoTSDT.101201547, DT.101734770, DT.94337699, DT.97363516
NIA Mouse Gene IndexU019661
Consensus CDS ProjectCCDS29967.2
International Mouse Knockout Project StatusSyp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017756 VEGA Gene Model | MGI Sequence Detail 14786 C57BL/6J ±  kb
transcript OTTMUST00000043002 VEGA | MGI Sequence Detail 2591 Not Applicable 
polypeptide OTTMUSP00000019333 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008253 Marvel
InterPro IPR001285 Synaptophysin/synaptoporin
Protein Ontology PR:000015890 synaptophysin
References (Earliest) J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(263)
Other
accession IDs
MGD-MRK-14690, MGI:2147923, MGI:2441790

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory