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Syp
Gene Detail
Symbol

Name
ID
Syp
synaptophysin
MGI:98467
Synonyms
A230093K24Rik, p38, Syn, Syp I
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.44 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
ChrX:7638471-7653256 bp, + strand
From VEGA annotation of GRCm38

  14786 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYP
Gene Tree: Syp

Human
homologs
SYP, synaptophysin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6855
neXtProt AC: NX_P08247

Human Synonyms: MRX96, MRXSYP

Human Chr (Location): Xp11.23-p11.22; chrX:49187812-49200202 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SYP

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
 
Interactions
Syp interacts with 170 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cellular response to organic substance, endocytosis, ...
Component cell junction, cytoplasmic vesicle, ...
Function cholesterol binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (192 records)
Data Summary: Results (99)    Tissues (58)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 29
Western blot 30
RT-PCR 9
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase syp ; ZFIN sypb    NEW 
Molecular
reagents
All nucleic(123) Genomic(12) cDNA(109) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017756 (Evidence)
Ensembl Gene Model ENSMUSG00000031144 (Evidence)
Entrez Gene 20977 (Evidence)
UniGene 223674
DFCI TC1573762, TC1614408, TC1676956, TC1758349
DoTS DT.101201547, DT.101734770, DT.94337699, DT.97363516
NIA Mouse Gene Index U019661
Consensus CDS Project CCDS29967.2
International Mouse Phenotyping Consortium Status Syp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017756 VEGA Gene Model | MGI Sequence Detail 14786 C57BL/6J ±  kb
transcript OTTMUST00000043002 VEGA | MGI Sequence Detail 2591 Not Applicable 
polypeptide OTTMUSP00000019333 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008253 Marvel
InterPro IPR001285 Synaptophysin/synaptoporin
Protein Ontology PR:000015890 synaptophysin
References
(Earliest) J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
(Latest) J:221387 Liu L, et al., Pre-synaptic localization of the gamma-secretase-inhibiting protein p24alpha2 in the mammalian brain. J Neurochem. 2015 May;133(3):422-31
All references(277)
Other
accession IDs
MGD-MRK-14690, MGI:2147923, MGI:2441790

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory