About   Help   FAQ
Due to maintenance, access to MGI maybe intermittent on Thu, May 23 at 7:30 AM ET.
Syp Gene Detail
Summary
  • Symbol
    Syp
  • Name
    synaptophysin
  • Synonyms
    A230093K24Rik, p38, Syn, Syp I
  • Feature Type
    protein coding gene
  • IDs
    MGI:98467
    NCBI Gene: 20977
  • Gene Overview
    MyGene.info: SYP
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7638580-7653256 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.44 cM, cytoband A-D
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98467
protein coding gene ChrX:7638471-7653256 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035515
protein coding gene ChrX:2251412-2266725 (+)
A/J MGP_AJ_G0035493
protein coding gene ChrX:2211985-2228064 (+)
AKR/J MGP_AKRJ_G0035426
protein coding gene ChrX:2313321-2329987 (+)
BALB/cJ MGP_BALBcJ_G0035489
protein coding gene ChrX:2230983-2246302 (+)
C3H/HeJ MGP_C3HHeJ_G0035197
protein coding gene ChrX:2285371-2300049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036013
protein coding gene ChrX:2328614-2343300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032888
protein coding gene ChrX:1780007-1794574 (+)
CAST/EiJ MGP_CASTEiJ_G0034497
protein coding gene ChrX:2185319-2200904 (+)
CBA/J MGP_CBAJ_G0035167
protein coding gene ChrX:2441707-2460736 (+)
DBA/2J MGP_DBA2J_G0035324
protein coding gene ChrX:2232988-2247681 (+)
FVB/NJ MGP_FVBNJ_G0035271
protein coding gene ChrX:2196928-2211515 (+)
LP/J MGP_LPJ_G0035401
protein coding gene ChrX:2252795-2267495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035310
protein coding gene ChrX:2406165-2423238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036031
protein coding gene ChrX:2234384-2249063 (+)
PWK/PhJ MGP_PWKPhJ_G0034199
protein coding gene ChrX:2165518-2180740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034036
protein coding gene ChrX:2204691-2219255 (+)
WSB/EiJ MGP_WSBEiJ_G0034620
protein coding gene ChrX:2237069-2254581 (+)



Homology
more
  • Human Ortholog
    SYP, synaptophysin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYP, synaptophysin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRX96, MRXSYP
  • Links
    NCBI Gene ID: 6855
    neXtProt AC: NX_P08247
    UniProt: P08247

  • Chr Location
    Xp11.23; chrX:49187812-49200202 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2391
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYP
  • Gene Tree
    Syp
Human Diseases
more
  • Diseases
    1 with human SYP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 phenotype references
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20977 NCBI Gene Model | MGI Sequence Detail 14677 C57BL/6J ±  kb
transcript NM_009305 RefSeq | MGI Sequence Detail 2482 C57BL/6  
polypeptide Q62277 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    Genomic 12
    cDNA 112
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14690, MGI:2147923, MGI:2441790
References
more
  • Summaries
    All 331
    Developmental Gene Expression 237
    Gene Ontology 43
    Phenotypes 16
  • Earliest
    J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
  • Latest
    J:268413 Wamsley B, et al., Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons. Neuron. 2018 Nov 21;100(4):846-859.e7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/07/2019
MGI 6.14
The Jackson Laboratory