Syp
Gene Detail

Symbol Name ID

Syp synaptophysin MGI:98467

Synonyms

A230093K24Rik, p38, Syn, Syp I

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.44 cM, cytoband A-D
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

ChrX:7638471-7653256 bp, + strand From VEGA annotation of GRCm38   14786 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Syp

Human homologs

Human Homolog		SYP, synaptophysin
NCBI Gene ID		6855
neXtProt AC		NX_P08247
Human Synonyms		MRXSYP
Human Chr (Location)		Xp11.23-p11.22; chrX:49044265-49056661 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SYP

Alleles and phenotypes

All alleles(27) : Targeted(4) Gene trapped(23)
 

Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	cellular response to organic substance, endocytosis, ...
Component	cell junction, cytoplasmic vesicle, ...
Function	cholesterol binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (169 records)
Data Summary: Results (90)    Tissues (53)    Images (13)
Theiler Stages: 16, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	29
Western blot	29
RT-PCR	9

cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) Genomic(12) cDNA(109) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017756 (Evidence)
Ensembl Gene Model	ENSMUSG00000031144 (Evidence)
Entrez Gene	20977 (Evidence)
UniGene	223674
DFCI	TC1573762, TC1614408, TC1676956, TC1758349
DoTS	DT.101201547, DT.101734770, DT.94337699, DT.97363516
NIA Mouse Gene Index	U019661
Consensus CDS Project	CCDS29967.2
International Mouse Knockout Project Status	Syp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017756	VEGA Gene Model | MGI Sequence Detail	14786	C57BL/6J
transcript	OTTMUST00000043002	VEGA | MGI Sequence Detail	2591	Not Applicable
polypeptide	OTTMUSP00000019333	VEGA | MGI Sequence Detail	314	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008253	Marvel
InterPro	IPR021128	MARVEL-like domain
InterPro	IPR001285	Synaptophysin/synaptoporin
Protein Ontology	PR:000015890	synaptophysin

References

(Earliest) J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
(Latest) J:187963 Talchai C, et al., Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell. 2012 Sep 14;150(6):1223-34
All references(248)

Other accession IDs

MGD-MRK-14690, MGI:2147923, MGI:2441790