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Syp Gene Detail
Summary
  • Symbol
    Syp
  • Name
    synaptophysin
  • Synonyms
    A230093K24Rik, p38, Syn, Syp I
  • Feature Type
    protein coding gene
  • IDs
    MGI:98467
    NCBI Gene: 20977
  • Gene Overview
    MyGene.info: SYP
Location & Maps
more
  • Genetic Map
    Chromosome X, 3.44 cM, cytoband A-D
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    SYP, synaptophysin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYP, synaptophysin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRX96, MRXSYP
  • Links
    NCBI Gene ID: 6855
    neXtProt AC: NX_P08247

  • Chr Location
    Xp11.23; chrX:49187812-49200202 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2391
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYP
  • Gene Tree
    Syp
Human Diseases
more
  • Diseases
    1 with human SYP associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 96; MRX96   OMIM: 300802
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    28
  • Gene trapped
    23
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017756 VEGA Gene Model | MGI Sequence Detail 14786 C57BL/6J ±  kb
transcript OTTMUST00000043002 VEGA | MGI Sequence Detail 2591 Not Applicable  
polypeptide OTTMUSP00000019333 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    68 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 125
    Genomic 12
    cDNA 110
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-14690, MGI:2147923, MGI:2441790
References
more
  • Summaries
    All 287
    Developmental Gene Expression 204
    Gene Ontology 39
    Phenotypes 14
  • Earliest
    J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
  • Latest
    J:235086 Valente P, et al., PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016 Apr 5;15(1):117-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory