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Surf1 Gene Detail
Summary
  • Symbol
    Surf1
  • Name
    surfeit gene 1
  • Synonyms
    0610010F23Rik, Surf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98443
    NCBI Gene: 20930
  • Member of
    Surf cluster
  • Gene Overview
    MyGene.info: SURF1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26913381-26916530 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.10 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98443
protein coding gene Chr2:26913378-26916530 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025500
protein coding gene Chr2:24885024-24888173 (-)
A/J MGP_AJ_G0025477
protein coding gene Chr2:23940913-23944062 (-)
AKR/J MGP_AKRJ_G0025447
protein coding gene Chr2:24721463-24724612 (-)
BALB/cJ MGP_BALBcJ_G0025473
protein coding gene Chr2:24059004-24062153 (-)
C3H/HeJ MGP_C3HHeJ_G0025234
protein coding gene Chr2:24660228-24663377 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025917
protein coding gene Chr2:25727067-25730216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023328
protein coding gene Chr2:22779819-22782902 (-)
CAST/EiJ MGP_CASTEiJ_G0024697
protein coding gene Chr2:24537338-24540479 (-)
CBA/J MGP_CBAJ_G0025212
protein coding gene Chr2:26618737-26621886 (-)
DBA/2J MGP_DBA2J_G0025345
protein coding gene Chr2:23757416-23760565 (-)
FVB/NJ MGP_FVBNJ_G0025307
protein coding gene Chr2:23512632-23515781 (-)
LP/J MGP_LPJ_G0025431
protein coding gene Chr2:24830669-24833818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025338
protein coding gene Chr2:26677735-26680884 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025976
protein coding gene Chr2:24662825-24665974 (-)
PWK/PhJ MGP_PWKPhJ_G0024445
protein coding gene Chr2:23551506-23554634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024245
protein coding gene Chr2:24815217-24818352 (-)
WSB/EiJ MGP_WSBEiJ_G0024766
protein coding gene Chr2:24780546-24783695 (-)



Homology
more
  • Human Ortholog
    SURF1, SURF1 cytochrome c oxidase assembly factor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SURF1, SURF1 cytochrome c oxidase assembly factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT4K
  • Links
    NCBI Gene ID: 6834
    neXtProt AC: NX_Q15526
    UniProt: Q15526

  • Chr Location
    9q34.2; chr9:133351805-133356485 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Surf1 mouse models; 2 with human SURF1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene affect calcium uptake by mitochondria in neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015790 Ensembl Gene Model | MGI Sequence Detail 3150 C57BL/6J ±  kb
    transcript ENSMUST00000015934 Ensembl | MGI Sequence Detail 1173 Not Applicable  
    polypeptide ENSMUSP00000015934 Ensembl | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 1
      cDNA 100
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14644, MGD-MRK-14651, MGI:1915586
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:29566 Williams TJ, et al., The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Mol Cell Biol. 1986 Dec;6(12):4558-69
    • Latest
      J:266664 Simard ML, et al., A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency. J Pathol. 2018 Jul;245(3):311-323

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory