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Surf1
Gene Detail
 Symbol
Name
ID
Member of
Surf1
surfeit gene 1
MGI:98443
Surf cluster
Synonyms 0610010F23Rik, Surf-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:26913383-26916530 bp, - strand
From VEGA annotation of GRCm38

  3148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2387  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SURF1 protein
Gene Tree: Surf1

Human
homologs
Human Homolog SURF1, surfeit 1
NCBI Gene ID 6834
neXtProt AC  NX_Q15526
Human Chr (Location)  9q34.2; chr9:133351805-133356670 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SURF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene affect calcium uptake by mitochondria in neurons.
 
Human Diseases Modeled Using Mouse Surf1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Surf1 interacts with 12 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process ATP biosynthetic process, hydrogen ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function cytochrome-c oxidase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (3)   
Theiler Stages: 11, 28
Assay TypeResults
Western blot 4
RT-PCR 6
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) Genomic(1) cDNA(99) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000011739 (Evidence)
Ensembl Gene ModelENSMUSG00000015790 (Evidence)
Entrez Gene20930 (Evidence)
UniGene347512
DFCITC1577028, TC1587141, TC1700446
NIA Mouse Gene IndexU022433
Consensus CDS ProjectCCDS50543.1
International Mouse Knockout Project StatusSurf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011739 VEGA Gene Model | MGI Sequence Detail 3148 C57BL/6J ±  kb
transcript OTTMUST00000027512 VEGA | MGI Sequence Detail 1173 Not Applicable 
polypeptide OTTMUSP00000012505 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(18) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002994 Surfeit locus 1/Shy1
Protein Ontology PR:000015840 surfeit locus protein 1
References (Earliest) J:29566 Williams TJ, et al., The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Mol Cell Biol. 1986 Dec;6(12):4558-69
(Latest) J:197658 Deepa SS, et al., Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr;27(4):1371-80
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14644, MGD-MRK-14651, MGI:1915586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory