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Surf1
Gene Detail
Symbol

Name
ID
Member of
Surf1
surfeit gene 1
MGI:98443
Surf cluster
Synonyms
0610010F23Rik, Surf-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:26913381-26916530 bp, - strand
From VEGA annotation of GRCm38

  3150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2387  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SURF1
Protein SuperFamily: SURF1 protein
Gene Tree: Surf1

Human
homologs
SURF1, surfeit 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6834
neXtProt AC: NX_Q15526

Human Chr (Location): 9q34.2; chr9:133351805-133356485 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SURF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene affect calcium uptake by mitochondria in neurons.
 
Human Diseases Modeled in Mice Using Surf1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Surf1 interacts with 12 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process ATP biosynthetic process, hydrogen ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function cytochrome-c oxidase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 4
RT-PCR 6
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase surf1    NEW 
Molecular
reagents
All nucleic(102) Genomic(1) cDNA(99) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000011739 (Evidence)
Ensembl Gene Model ENSMUSG00000015790 (Evidence)
Entrez Gene 20930 (Evidence)
UniGene 347512
DFCI TC1577028, TC1587141, TC1700446
NIA Mouse Gene Index U022433
Consensus CDS Project CCDS50543.1
International Mouse Phenotyping Consortium Status Surf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011739 VEGA Gene Model | MGI Sequence Detail 3150 C57BL/6J ±  kb
transcript OTTMUST00000027512 VEGA | MGI Sequence Detail 1173 Not Applicable 
polypeptide OTTMUSP00000012505 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(18) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002994 Surfeit locus 1/Shy1
Protein Ontology PR:000015840 surfeit locus protein 1
References
(Earliest) J:29566 Williams TJ, et al., The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Mol Cell Biol. 1986 Dec;6(12):4558-69
(Latest) J:197658 Deepa SS, et al., Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr;27(4):1371-80
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14644, MGD-MRK-14651, MGI:1915586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory