Surf1
Gene Detail

Symbol Name ID

Surf1 surfeit gene 1 MGI:98443

Synonyms

0610010F23Rik, Surf-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:26913383-26916530 bp, - strand From VEGA annotation of GRCm38   3148 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SURF1 protein
Gene Tree: Surf1

Human homologs

Human Homolog		SURF1, surfeit 1
NCBI Gene ID		6834
neXtProt AC		NX_Q15526
Human Chr (Location)		9q34.2; chr9:136218666-136223361 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SURF1

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mutations in this gene affect calcium uptake by mitochondria in neurons.

 
Human Diseases Modeled Using Mouse Surf1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	ATP biosynthetic process, ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	cytochrome-c oxidase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (3)   
Theiler Stages: 11, 28

Assay Type	Results
Western blot	4
RT-PCR	6

cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(102) Genomic(1) cDNA(99) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000011739 (Evidence)
Ensembl Gene Model	ENSMUSG00000015790 (Evidence)
Entrez Gene	20930 (Evidence)
UniGene	347512
DFCI	TC1577028, TC1587141, TC1700446
NIA Mouse Gene Index	U022433
Consensus CDS Project	CCDS50543.1
International Mouse Knockout Project Status	Surf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011739	VEGA Gene Model | MGI Sequence Detail	3148	C57BL/6J
transcript	OTTMUST00000027512	VEGA | MGI Sequence Detail	1173	Not Applicable
polypeptide	OTTMUSP00000012505	VEGA | MGI Sequence Detail	338	Not Applicable

All sequences(51) RefSeq(5) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002994	Surfeit locus 1
Protein Ontology	PR:000015840	surfeit locus protein 1

References

(Earliest) J:29566 Williams TJ, et al., The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Mol Cell Biol. 1986 Dec;6(12):4558-69
(Latest) J:192149 Stettner GM, et al., Hypoxic and hypercapnic challenges unveil respiratory vulnerability of Surf1 knockout mice, an animal model of Leigh syndrome. Mitochondrion. 2011 May;11(3):413-20
All references(44)

Other accession IDs

MGD-MRK-14644, MGD-MRK-14651, MGI:1915586