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Sult1e1 Gene Detail
Summary
  • Symbol
    Sult1e1
  • Name
    sulfotransferase family 1E, member 1
  • Synonyms
    EST, Ste
  • Feature Type
    protein coding gene
  • IDs
    MGI:98431
    NCBI Gene: 20860
  • Gene Overview
    MyGene.info: SULT1E1
Location & Maps
more
  • Sequence Map
    Chr5:87575969-87591594 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15626 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    SULT1E1, sulfotransferase family 1E member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SULT1E1, sulfotransferase family 1E member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EST, EST-1, ST1E1, STE
  • Links
    NCBI Gene ID: 6783
    neXtProt AC: NX_P49888

  • Chr Location
    4q13.1; chr4:69841212-69860765 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Sult1e1
  • Incidental Mutations
Homozygous null mice exhibit reduced fertility. Males exhibit abnormal testis morphology with Leydig cell hypertrophy and hyperplasia and reduced caudal sperm motility. Spontaneous fetal loss caused by placental thrombosis occurs in pregnant females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054067 VEGA Gene Model | MGI Sequence Detail 15626 C57BL/6J ±  kb
transcript OTTMUST00000134350 VEGA | MGI Sequence Detail 1242 Not Applicable  
polypeptide OTTMUSP00000071254 VEGA | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14619
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:26013 Leiter EH, et al., The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology. 1989 Feb;124(2):912-22
  • Latest
    J:227422 Karpova T, et al., Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice. Biol Reprod. 2015 Oct;93(4):83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory