About   Help   FAQ
Sult1e1
Gene Detail
Symbol

Name
ID
Sult1e1
sulfotransferase family 1E, member 1
MGI:98431
Synonyms
EST, Ste
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:87575968-87591611 bp, - strand
From NCBI annotation of GRCm38

  15644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SULT1E1
Protein SuperFamily: PAPS sulfotransferase
Gene Tree: Sult1e1

Human
homologs
SULT1E1, sulfotransferase family 1E, estrogen-preferring, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6783
neXtProt AC: NX_P49888

Human Synonyms: EST, EST-1, ST1E1, STE

Human Chr (Location): 4q13.1; chr4:69841212-69860765 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced fertility. Males exhibit abnormal testis morphology with Leydig cell hypertrophy and hyperplasia and reduced caudal sperm motility. Spontaneous fetal loss caused by placental thrombosis occurs in pregnant females.
 
Interactions
Sult1e1 interacts with 55 markers (Mir16-2, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process estrogen metabolic process, female pregnancy, ...
Component cytoplasm
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (123)    Tissues (106)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
Northern blot 15
Western blot 4
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sult1e1    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029272 (Evidence)
Entrez Gene 20860 (Evidence)
UniGene 89655
DFCI TC1587244
DoTS DT.55196987
NIA Mouse Gene Index U026366
EC 2.8.2.-, 2.8.2.4
PDB 1AQU, 1AQY, 1BO6
Consensus CDS Project CCDS19392.1
International Mouse Phenotyping Consortium Status Sult1e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20860 NCBI Gene Model | MGI Sequence Detail 15644 C57BL/6J ±  kb
transcript NM_023135 RefSeq | MGI Sequence Detail 1260 C57BL/6 
polypeptide P49891 UniProt | EBI | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000034347 estrogen sulfotransferase, testis isoform
Graphical View of Protein Domain Structure
References
(Earliest) J:26013 Leiter EH, et al., The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology. 1989 Feb;124(2):912-22
(Latest) J:220734 Zhang L, et al., Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4003-8
All references(48)
Other
accession IDs
MGD-MRK-14619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory