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Sult1e1
Gene Detail
 Symbol
Name
ID
Sult1e1
sulfotransferase family 1E, member 1
MGI:98431
Synonyms EST, Ste
Feature Type protein coding gene
Genetic Map
Chromosome 5
43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:87575968-87591611 bp, - strand
From NCBI annotation of GRCm38

  15644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101388  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: PAPS sulfotransferase
Gene Tree: Sult1e1

Human
homologs
Human Homolog SULT1E1, sulfotransferase family 1E, estrogen-preferring, member 1
NCBI Gene ID 6783
neXtProt AC  NX_P49888
Human Synonyms  EST, EST-1, ST1E1, STE
Human Chr (Location)  4q13.1; chr4:69841212-69860152 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced fertility. Males exhibit abnormal testis morphology with Leydig cell hypertrophy and hyperplasia and reduced caudal sperm motility. Spontaneous fetal loss caused by placental thrombosis occurs in pregnant females.
 
Interactions
Sult1e1 interacts with 55 markers (Mir16-2, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process estrogen metabolic process, female pregnancy, ...
Component cytoplasm
Function estrone sulfotransferase activity, flavonol 3-sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (123)    Tissues (106)    Images (11)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 104
Northern blot 15
Western blot 4
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029272 (Evidence)
Entrez Gene20860 (Evidence)
UniGene89655
DFCITC1587244
DoTSDT.55196987
NIA Mouse Gene IndexU026366
EC2.8.2.4
PDB1AQU, 1AQY, 1BO6
Consensus CDS ProjectCCDS19392.1
International Mouse Knockout Project StatusSult1e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20860 NCBI Gene Model | MGI Sequence Detail 15644 C57BL/6J ±  kb
transcript NM_023135 RefSeq | MGI Sequence Detail 1260 C57BL/6 
polypeptide P49891 UniProt | EBI | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000034347 estrogen sulfotransferase, testis isoform
Graphical View of Protein Domain Structure
References (Earliest) J:26013 Leiter EH, et al., The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology. 1989 Feb;124(2):912-22
(Latest) J:196848 Gao J, et al., Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes. 2012 Jun;61(6):1543-51
All references(49)
Other
accession IDs
MGD-MRK-14619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory