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Ssb
Gene Detail
 Symbol
Name
ID
Ssb
Sjogren syndrome antigen B
MGI:98423
Synonyms autoantigen La, La protein, SS-B
Feature Type protein coding gene
Genetic Map
Chromosome 2
40.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:69861562-69871786 bp, + strand
From VEGA annotation of GRCm38

  10225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ribonucleoprotein La
Gene Tree: Ssb

Human
homologs
Human Homolog SSB, Sjogren syndrome antigen B (autoantigen La)
NCBI Gene ID 6741
neXtProt AC  NX_P05455
Human Synonyms  La, LARP3, La/SSB
Human Chr (Location)  2q31.1; chr2:169798812-169812064 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(31) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos, possible before implantation.
 
Interactions
Ssb interacts with 212 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process RNA processing, tRNA processing
Component nucleus, ribonucleoprotein complex
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (31)    Tissues (31)    Images (6)
Theiler Stages: 2, 3, 4, 5, 21, 28
Assay TypeResults
RNA in situ 20
RT-PCR 11
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000013038 (Evidence)
Ensembl Gene ModelENSMUSG00000068882 (Evidence)
Entrez Gene20823 (Evidence)
NIA Mouse Gene IndexU001875
Consensus CDS ProjectCCDS16101.1
International Mouse Knockout Project StatusSsb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013038 VEGA Gene Model | MGI Sequence Detail 10225 C57BL/6J ±  kb
transcript OTTMUST00000031436 VEGA | MGI Sequence Detail 2001 Not Applicable 
polypeptide OTTMUSP00000014043 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(9)
Polymorphisms SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002344 Lupus La protein
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR014886 RNA-binding motif
InterPro IPR006630 RNA-binding protein Lupus La
InterPro IPR000504 RNA recognition motif domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015647 lupus La protein
References (Earliest) J:4633 Topfer F, et al., Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. J Immunol. 1993 Apr 1;150(7):3091-100
(Latest) J:207687 Gaidamakov S, et al., Targeted deletion of the gene encoding the La autoantigen (Sjogren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol. 2014 Jan;34(1):123-31
All references(37)
Other
accession IDs
MGD-MRK-14607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory