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Ssb
Gene Detail
Symbol

Name
ID
Ssb
Sjogren syndrome antigen B
MGI:98423
Synonyms
autoantigen La, La protein, SS-B
Feature Type
protein coding gene
Genetic Map
Chromosome 2
40.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:69861562-69871786 bp, + strand
From VEGA annotation of GRCm38

  10225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SSB
Protein SuperFamily: ribonucleoprotein La
Gene Tree: Ssb

Human
homologs
SSB, Sjogren syndrome antigen B (autoantigen La)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6741
neXtProt AC: NX_P05455

Human Synonyms: La, LARP3, La/SSB

Human Chr (Location): 2q31.1; chr2:169798812-169812064 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(31) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die as embryos, possible before implantation.
 
Interactions
Ssb interacts with 212 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process RNA processing, tRNA processing
Component nucleus, ribonucleoprotein complex
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (27)    Tissues (27)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 7
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SSB ; Xenbase ssb ; ZFIN ssb    NEW 
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000013038 (Evidence)
Ensembl Gene Model ENSMUSG00000068882 (Evidence)
Entrez Gene 20823 (Evidence)
NIA Mouse Gene Index U001875
Consensus CDS Project CCDS16101.1
International Mouse Phenotyping Consortium Status Ssb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013038 VEGA Gene Model | MGI Sequence Detail 10225 C57BL/6J ±  kb
transcript OTTMUST00000031436 VEGA | MGI Sequence Detail 2001 Not Applicable 
polypeptide OTTMUSP00000014043 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002344 Lupus La protein
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR014886 RNA-binding motif
InterPro IPR006630 RNA-binding protein Lupus La
InterPro IPR000504 RNA recognition motif domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015647 lupus La protein
References
(Earliest) J:4633 Topfer F, et al., Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. J Immunol. 1993 Apr 1;150(7):3091-100
(Latest) J:207687 Gaidamakov S, et al., Targeted deletion of the gene encoding the La autoantigen (Sjogren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol. 2014 Jan;34(1):123-31
All references(36)
Other
accession IDs
MGD-MRK-14607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory