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Ssb Gene Detail
Summary
  • Symbol
    Ssb
  • Name
    Sjogren syndrome antigen B
  • Synonyms
    autoantigen La, La protein, SS-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:98423
    NCBI Gene: 20823
  • Gene Overview
    MyGene.info: SSB
Location & Maps
more
  • Sequence Map
    Chr2:69861562-69871786 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10225 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 40.95 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SSB, Sjogren syndrome antigen B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSB, Sjogren syndrome antigen B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    La, LARP3, La/SSB
  • Links
    NCBI Gene ID: 6741
    neXtProt AC: NX_P05455

  • Chr Location
    2q31.1; chr2:169798812-169812064 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Gene trapped
    31
  • Targeted
    5
  • Genomic Mutations
    1 involving Ssb
  • Incidental Mutations
Mice homozygous for disruptions in this gene die as embryos, possible before implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013038 VEGA Gene Model | MGI Sequence Detail 10225 C57BL/6J ±  kb
transcript OTTMUST00000031436 VEGA | MGI Sequence Detail 2001 Not Applicable  
polypeptide OTTMUSP00000014043 VEGA | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015647 lupus La protein
  • InterPro Domains
    IPR014886 La protein, RNA-binding domain
    IPR002344 Lupus La protein
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR006630 RNA-binding protein Lupus La
    IPR000504 RNA recognition motif domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14607
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:4633 Topfer F, et al., Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. J Immunol. 1993 Apr 1;150(7):3091-100
  • Latest
    J:207687 Gaidamakov S, et al., Targeted deletion of the gene encoding the La autoantigen (Sjogren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol. 2014 Jan;34(1):123-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory