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Spn Gene Detail
Summary
  • Symbol
    Spn
  • Name
    sialophorin
  • Synonyms
    3E8 antigen, A630014B01Rik, Cd43, Galgp, leukosialin, Ly48, Ly-48
  • Feature Type
    protein coding gene
  • IDs
    MGI:98384
    NCBI Gene: 20737
  • Gene Overview
    MyGene.info: SPN
Location & Maps
more
  • Sequence Map
    Chr7:127132232-127137823 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5592 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SPN, sialophorin
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SPN, sialophorin
    Orthology source: HomoloGene
  • Synonyms
    CD43, GALGP, GPL115, LSN
  • Links
    NCBI Gene ID: 6693
    neXtProt AC: NX_P16150

  • Chr Location
    16p11.2; chr16:29662950-29670507 (+)  GRCh38.p2

Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Spn
  • Incidental Mutations
Mice homozygous for a knock-out allele show increased T cell proliferation in response to various stimulation agents and natural antigens, enhanced homotypic adhesion, transient resistance to melanoma growth and metastasis, and decreased susceptibility to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029411 VEGA Gene Model | MGI Sequence Detail 5592 C57BL/6J ±  kb
transcript OTTMUST00000072890 VEGA | MGI Sequence Detail 3743 Not Applicable  
polypeptide OTTMUSP00000037622 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 40
    Genomic 4
    cDNA 36

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11990, MGD-MRK-14534, MGD-MRK-1861, MGI:2443309
References
more
  • Summaries
    All 91
    Diseases 6
    Gene Ontology 24
    Phenotypes 48
  • Earliest
    J:10530 Cyster J, et al., Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr;20(4):875-81
  • Latest
    J:202563 Zhou HF, et al., CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013 May 15;190(10):5078-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory