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Spn
Gene Detail
Symbol

Name
ID
Spn
sialophorin
MGI:98384
Synonyms
3E8 antigen, A630014B01Rik, Cd43, Galgp, leukosialin, Ly48, Ly-48
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.35 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:127132232-127137823 bp, - strand
From VEGA annotation of GRCm38

  5592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: leukosialin
Gene Tree: Spn

Human
homologs
Human Homolog SPN, sialophorin
NCBI Gene ID 6693
neXtProt AC  NX_P16150
Human Synonyms  CD43, GALGP, GPL115, LSN
Human Chr (Location)  16p11.2; chr16:29662950-29670507 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Spn (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show increased T cell proliferation in response to various stimulation agents and natural antigens, enhanced homotypic adhesion, transient resistance to melanoma growth and metastasis, and decreased susceptibility to experimental autoimmune encephalomyelitis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Spn interacts with 318 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process apoptotic signaling pathway, cell surface receptor signaling pathway, ...
Component basement membrane, cell surface, ...
Function protein binding, protein domain specific binding
External Resources: FuncBase
Expression
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(4) cDNA(36)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000029411 (Evidence)
Ensembl Gene ModelENSMUSG00000051457 (Evidence)
Entrez Gene20737 (Evidence)
UniGene283714
DFCITC1585374, TC1590217, TC1620664, TC1754706
DoTSDT.101361157, DT.101724773, DT.94282525
NIA Mouse Gene IndexU029278
PDB2EMS
Consensus CDS ProjectCCDS21858.1
International Mouse Knockout Project StatusSpn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029411 VEGA Gene Model | MGI Sequence Detail 5592 C57BL/6J ±  kb
transcript OTTMUST00000072891 VEGA | MGI Sequence Detail 2161 Not Applicable 
polypeptide OTTMUSP00000037623 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(7) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000001879 leukosialin
References
(Earliest) J:10530 Cyster J, et al., Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr;20(4):875-81
(Latest) J:202563 Zhou HF, et al., CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013 May 15;190(10):5078-85
All references(94)
Other
accession IDs
MGD-MRK-11990, MGD-MRK-14534, MGD-MRK-1861, MGI:2443309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory