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Spn
Gene Detail
Symbol

Name
ID
Spn
sialophorin
MGI:98384
Synonyms
3E8 antigen, A630014B01Rik, Cd43, Galgp, leukosialin, Ly48, Ly-48
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.35 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:127132232-127137823 bp, - strand
From VEGA annotation of GRCm38

  5592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36108  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: SPN
Protein SuperFamily: leukosialin
Gene Tree: Spn

Human
homologs
SPN, sialophorin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6693
neXtProt AC: NX_P16150

Human Synonyms: CD43, GALGP, GPL115, LSN

Human Chr (Location): 16p11.2; chr16:29662950-29670507 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Genomic Mutations involving Spn (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show increased T cell proliferation in response to various stimulation agents and natural antigens, enhanced homotypic adhesion, transient resistance to melanoma growth and metastasis, and decreased susceptibility to experimental autoimmune encephalomyelitis.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Spn interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process apoptotic signaling pathway, cell surface receptor signaling pathway, ...
Component basement membrane, cell surface, ...
Function protein binding, protein domain specific binding
External Resources: FuncBase
Expression
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(4) cDNA(36)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029411 (Evidence)
Ensembl Gene Model ENSMUSG00000051457 (Evidence)
Entrez Gene 20737 (Evidence)
UniGene 283714
DFCI TC1585374, TC1590217, TC1620664, TC1754706
DoTS DT.101361157, DT.101724773, DT.94282525
NIA Mouse Gene Index U029278
PDB 2EMS
Consensus CDS Project CCDS21858.1
International Mouse Phenotyping Consortium Status Spn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029411 VEGA Gene Model | MGI Sequence Detail 5592 C57BL/6J ±  kb
transcript OTTMUST00000072891 VEGA | MGI Sequence Detail 2161 Not Applicable 
polypeptide OTTMUSP00000037623 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(11) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000001879 leukosialin
References
(Earliest) J:10530 Cyster J, et al., Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990 Apr;20(4):875-81
(Latest) J:202563 Zhou HF, et al., CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013 May 15;190(10):5078-85
All references(93)
Other
accession IDs
MGD-MRK-11990, MGD-MRK-14534, MGD-MRK-1861, MGI:2443309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory