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Sparc Gene Detail
Summary
  • Symbol
    Sparc
  • Name
    secreted acidic cysteine rich glycoprotein
  • Synonyms
    BM-40, osteonectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98373
    NCBI Gene: 20692
  • Gene Overview
    MyGene.info: SPARC
Location & Maps
more
  • Sequence Map
    Chr11:55394500-55420080 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25581 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 33.04 cM, cytoband B1
  • Mapping Data
    48 experiments
Homology
more
  • Human Ortholog
    SPARC, secreted protein acidic and cysteine rich
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPARC, secreted protein acidic and cysteine rich
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BM-40, OI17, ON
  • Links
    NCBI Gene ID: 6678
    neXtProt AC: NX_P09486

  • Chr Location
    5q31.3-q32; chr5:151661096-151687054 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SPARC associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type Xvii; OI17   OMIM: 616507
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 4 alleles in 4 genetic backgrounds
    3 images
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    182
  • Chemically induced (other)
    1
  • Gene trapped
    173
  • Targeted
    8
  • Genomic Mutations
    3 involving Sparc
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit cataracts, reduced skin collagen content, accelerated wound closure, osteopenia associated with reduced bone remodeling, and increased growth of implanted tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005692 VEGA Gene Model | MGI Sequence Detail 25581 C57BL/6J ±  kb
transcript OTTMUST00000012666 VEGA | MGI Sequence Detail 2300 Not Applicable  
polypeptide OTTMUSP00000005868 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    299 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1263
    Genomic 4
    cDNA 1254
    Primer pair 1
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14514, MGI:2144017
References
more
  • Summaries
    All 217
    Developmental Gene Expression 40
    Diseases 1
    Gene Ontology 11
    Phenotypes 94
  • Earliest
    J:8388 Mason IJ, et al., Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J. 1986 Jul;5(7):1465-72
  • Latest
    J:232948 Tseng C, et al., Proteolytic Isoforms of SPARC Induce Adipose Stromal Cell Mobilization in Obesity. Stem Cells. 2016 Jan;34(1):174-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory