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Sparc Gene Detail
Summary
  • Symbol
    Sparc
  • Name
    secreted acidic cysteine rich glycoprotein
  • Synonyms
    BM-40, osteonectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98373
    NCBI Gene: 20692
  • Gene Overview
    MyGene.info: SPARC
  • Alliance
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:55394159-55420080 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 33.04 cM, cytoband B1
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98373
protein coding gene Chr11:55394159-55423183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018330
protein coding gene Chr11:54920265-54947680 (-)
A/J MGP_AJ_G0018299
protein coding gene Chr11:52876583-52903396 (-)
AKR/J MGP_AKRJ_G0018268
protein coding gene Chr11:54598753-54625487 (-)
BALB/cJ MGP_BALBcJ_G0018270
protein coding gene Chr11:53203986-53229726 (-)
C3H/HeJ MGP_C3HHeJ_G0018081
protein coding gene Chr11:54536322-54563018 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018722
protein coding gene Chr11:56584433-56614336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016372
protein coding gene Chr11:50297314-50323437 (-)
CAST/EiJ MGP_CASTEiJ_G0017646
protein coding gene Chr11:54579080-54612109 (-)
CBA/J MGP_CBAJ_G0018056
protein coding gene Chr11:59276476-59309670 (-)
DBA/2J MGP_DBA2J_G0018165
protein coding gene Chr11:52561448-52587493 (-)
FVB/NJ MGP_FVBNJ_G0018157
protein coding gene Chr11:52227536-52254129 (-)
LP/J MGP_LPJ_G0018240
protein coding gene Chr11:55382934-55409946 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018183
protein coding gene Chr11:60453249-60482613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018764
protein coding gene Chr11:54623135-54650346 (-)
PWK/PhJ MGP_PWKPhJ_G0017419
protein coding gene Chr11:53134002-53160309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017214
protein coding gene Chr11:54416184-54442622 (-)
WSB/EiJ MGP_WSBEiJ_G0017694
protein coding gene Chr11:54266316-54293091 (-)



Homology
more
  • Human Ortholog
    SPARC, secreted protein acidic and cysteine rich
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPARC, secreted protein acidic and cysteine rich
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM-40, OI17, ON
  • Links
    NCBI Gene ID: 6678
    neXtProt AC: NX_P09486
    UniProt: P09486

  • Chr Location
    5q33.1; chr5:151661096-151687054 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SPARC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 4 alleles in 4 genetic backgrounds
    3 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit cataracts, reduced skin collagen content, accelerated wound closure, osteopenia associated with reduced bone remodeling, and increased growth of implanted tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20692 NCBI Gene Model | MGI Sequence Detail 25922 C57BL/6J ±  kb
    transcript NM_009242 RefSeq | MGI Sequence Detail 2641 C57BL/6  
    polypeptide P07214 UniProt | EBI | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1266
      Genomic 4
      cDNA 1257
      Primer pair 1
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14514, MGI:2144017
    References
    more
    • Summaries
      All 240
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 15
      Phenotypes 100
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264496 Mazzolini G, et al., SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease. Sci Rep. 2018 Jan 15;8(1):725

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory