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Sparc
Gene Detail
 Symbol
Name
ID
Sparc
secreted acidic cysteine rich glycoprotein
MGI:98373
Synonyms BM-40, osteonectin
Feature Type protein coding gene
Genetic Map
Chromosome 11
33.04 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(48)
Sequence Map
Chr11:55394500-55420080 bp, - strand
From VEGA annotation of GRCm38

  25581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: osteonectin
Gene Tree: Sparc

Human
homologs
Human Homolog SPARC, secreted protein, acidic, cysteine-rich (osteonectin)
NCBI Gene ID 6678
neXtProt AC  NX_P09486
Human Synonyms  ON
Human Chr (Location)  5q31.3-q32; chr5:151661096-151687054 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(180) : Gene trapped(173) Targeted(7)
Genomic Mutations involving Sparc (1)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit cataracts, reduced skin collagen content, accelerated wound closure, osteopenia associated with reduced bone remodeling, and increased growth of implanted tumors.
 
Phenotype Images(3)
Interactions
Sparc interacts with 160 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process bone development, cellular response to growth factor stimulus, ...
Component basement membrane, cell surface, ...
Function calcium ion binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (298)    Tissues (206)    Images (102)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 103
RNA in situ 139
Northern blot 56
cDNA source data(1253)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1263) Genomic(4) cDNA(1254) Primer pair(1) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005692 (Evidence)
Ensembl Gene ModelENSMUSG00000018593 (Evidence)
Entrez Gene20692 (Evidence)
UniGene291442
DFCITC1573651, TC1613073, TC1635401, TC1700165
DoTSDT.101374812, DT.101741180, DT.101741181, DT.101741182, DT.102554098, DT.55145983, DT.91401123, DT.91416959, DT.94283690, DT.94283824
NIA Mouse Gene IndexU032790
Consensus CDS ProjectCCDS24712.1, CCDS70189.1
International Mouse Knockout Project StatusSparc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005692 VEGA Gene Model | MGI Sequence Detail 25581 C57BL/6J ±  kb
transcript OTTMUST00000012666 VEGA | MGI Sequence Detail 2300 Not Applicable 
polypeptide OTTMUSP00000005868 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(6) UniProt(5)
Polymorphisms RFLP(9) : SNPs within 2kb(300 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR011992 EF-hand-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
InterPro IPR001999 Osteonectin-like, conserved site
InterPro IPR019577 SPARC/Testican, calcium-binding domain
Protein Ontology PR:000015475 SPARC
References (Earliest) J:8388 Mason IJ, et al., Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J. 1986 Jul;5(7):1465-72
(Latest) J:212014 Luo Z, et al., SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis. J Leukoc Biol. 2014 Jul;96(1):73-82
All references(210)
Other
accession IDs
MGD-MRK-14514, MGI:2144017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory