About   Help   FAQ
Due to maintenance, access to MGI maybe intermittent on Thu, May 23 at 7:30 AM ET.
Sox8 Gene Detail
Summary
  • Symbol
    Sox8
  • Name
    SRY (sex determining region Y)-box 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:98370
    NCBI Gene: 20681
  • Gene Overview
    MyGene.info: SOX8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25565893-25570686 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98370
protein coding gene Chr17:25565892-25570686 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023358
protein coding gene Chr17:24646333-24651098 (-)
A/J MGP_AJ_G0023317
protein coding gene Chr17:23937331-23942118 (-)
AKR/J MGP_AKRJ_G0023283
protein coding gene Chr17:24039993-24044779 (-)
BALB/cJ MGP_BALBcJ_G0023322
protein coding gene Chr17:24161125-24165910 (-)
C3H/HeJ MGP_C3HHeJ_G0023082
protein coding gene Chr17:24418936-24423706 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023764
protein coding gene Chr17:25704127-25708899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021240
protein coding gene Chr17:21403343-21408118 (-)
CAST/EiJ MGP_CASTEiJ_G0022584
protein coding gene Chr17:24291838-24296612 (-)
CBA/J MGP_CBAJ_G0023057
protein coding gene Chr17:26596757-26601542 (-)
DBA/2J MGP_DBA2J_G0023187
protein coding gene Chr17:23536004-23540805 (-)
FVB/NJ MGP_FVBNJ_G0023157
protein coding gene Chr17:23257237-23262428 (-)
LP/J MGP_LPJ_G0023264
protein coding gene Chr17:24938399-24943175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023176
protein coding gene Chr17:26227688-26232482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023804
protein coding gene Chr17:24340362-24345158 (-)
PWK/PhJ MGP_PWKPhJ_G0022333
protein coding gene Chr17:22291766-22296590 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022151
protein coding gene Chr17:22420059-22424841 (-)
WSB/EiJ MGP_WSBEiJ_G0022647
protein coding gene Chr17:24406020-24410791 (-)



Homology
more
  • Human Ortholog
    SOX8, SRY-box 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOX8, SRY-box 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 30812
    neXtProt AC: NX_P57073
    UniProt: P57073

  • Chr Location
    16p13.3; chr16:981808-986979 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7950
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SOX8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a 30% decrease in adult body weight due to diminished fat stores, and a reduction of several tarsals which subsequently fail to fuse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20681 NCBI Gene Model | MGI Sequence Detail 4794 C57BL/6J ±  kb
    transcript NM_011447 RefSeq | MGI Sequence Detail 2999 C57BL/6  
    polypeptide Q04886 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 34
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14509
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 53
      Gene Ontology 24
      Phenotypes 26
    • Earliest
      J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
    • Latest
      J:260791 Truch K, et al., Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease. Hum Mol Genet. 2018 Mar 15;27(6):1078-1092

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/07/2019
    MGI 6.14
    The Jackson Laboratory