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Sox8 Gene Detail
Summary
  • Symbol
    Sox8
  • Name
    SRY (sex determining region Y)-box 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:98370
    NCBI Gene: 20681
  • Gene Overview
    MyGene.info: SOX8
Location & Maps
more
  • Sequence Map
    Chr17:25565892-25570686 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4795 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.69 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SOX8, SRY-box 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOX8, SRY-box 8
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 30812
    neXtProt AC: NX_P57073

  • Chr Location
    16p13.3; chr16:981808-986979 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7950
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SOX8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    2 involving Sox8
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit a 30% decrease in adult body weight due to diminished fat stores, and a reduction of several tarsals which subsequently fail to fuse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038220 VEGA Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
transcript OTTMUST00000098394 VEGA | MGI Sequence Detail 3000 Not Applicable  
polypeptide OTTMUSP00000055292 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000015434 transcription factor SOX-8
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR022151 Sox developmental protein N-terminal
    IPR031265 Transcription factor SOX-8
Molecular
Reagents
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  • All nucleic 35
    cDNA 32
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14509
References
more
  • Summaries
    All 82
    Developmental Gene Expression 44
    Gene Ontology 24
    Phenotypes 22
  • Earliest
    J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
  • Latest
    J:229536 Kawasaki K, et al., Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59(10-12):471-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory