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Sox8
Gene Detail
Symbol

Name
ID
Sox8
SRY (sex determining region Y)-box 8
MGI:98370
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:25565892-25570686 bp, - strand
From VEGA annotation of GRCm38

  4795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOX8
Gene Tree: Sox8

Human
homologs
SOX8, SRY (sex determining region Y)-box 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 30812
neXtProt AC: NX_P57073

Human Chr (Location): 16p13.3; chr16:981808-986979 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(2) Targeted(4)
Genomic Mutations involving Sox8 (2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit a 30% decrease in adult body weight due to diminished fat stores, and a reduction of several tarsals which subsequently fail to fuse.
 
Interactions
Sox8 interacts with 171 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process adipose tissue development, astrocyte fate commitment, ...
Component cytoplasm, nuclear transcription factor complex, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (586)    Tissues (155)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 471
In situ reporter (knock in) 11
RT-PCR 95
cDNA source data(30)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX8 ; Xenbase sox8 ; ZFIN sox8b    NEW 
Molecular
reagents
All nucleic(34) cDNA(31) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000038220 (Evidence)
Ensembl Gene Model ENSMUSG00000024176 (Evidence)
Entrez Gene 20681 (Evidence)
UniGene 258220
DFCI TC1582300, TC1592018, TC1606919
DoTS DT.101295480, DT.101366564, DT.523188
NIA Mouse Gene Index U037556
Consensus CDS Project CCDS28521.1
International Mouse Phenotyping Consortium Status Sox8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038220 VEGA Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
transcript OTTMUST00000098394 VEGA | MGI Sequence Detail 3000 Not Applicable 
polypeptide OTTMUSP00000055292 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022151 Sox developmental protein N-terminal
Protein Ontology PR:000015434 transcription factor SOX-8
References
(Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(81)
Other
accession IDs
MGD-MRK-14509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory