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Sox8
Gene Detail
 Symbol
Name
ID
Sox8
SRY (sex determining region Y)-box 8
MGI:98370
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:25565892-25570686 bp, - strand
From VEGA annotation of GRCm38

  4795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox8

Human
homologs
Human Homolog SOX8, SRY (sex determining region Y)-box 8
NCBI Gene ID 30812
neXtProt AC  NX_P57073
Human Chr (Location)  16p13.3; chr16:981808-986979 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(2) Targeted(4)
Genomic Mutations involving Sox8 (2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit a 30% decrease in adult body weight due to diminished fat stores, and a reduction of several tarsals which subsequently fail to fuse.
 
Interactions
Sox8 interacts with 171 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process adipose tissue development, astrocyte fate commitment, ...
Component cytoplasm, nuclear transcription factor complex, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (586)    Tissues (155)    Images (52)
Theiler Stages: 15, 17, 18, 19, 20, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 471
In situ reporter (knock in) 11
RT-PCR 95
cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(31) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000038220 (Evidence)
Ensembl Gene ModelENSMUSG00000024176 (Evidence)
Entrez Gene20681 (Evidence)
UniGene258220
DFCITC1582300, TC1592018, TC1606919
DoTSDT.101295480, DT.101366564, DT.523188
NIA Mouse Gene IndexU037556
Consensus CDS ProjectCCDS28521.1
International Mouse Knockout Project StatusSox8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038220 VEGA Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
transcript OTTMUST00000098394 VEGA | MGI Sequence Detail 3000 Not Applicable 
polypeptide OTTMUSP00000055292 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(7)
Polymorphisms PCR(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022151 Sox developmental protein N-terminal
Protein Ontology PR:000015434 transcription factor SOX-8
References (Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:202064 Singh AP, et al., SOX8 regulates permeability of the blood-testes barrier that affects adult male fertility in the mouse. Biol Reprod. 2013 May;88(5):133
All references(81)
Other
accession IDs
MGD-MRK-14509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory