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Sox7
Gene Detail
Symbol

Name
ID
Sox7
SRY (sex determining region Y)-box 7
MGI:98369
Feature Type
protein coding gene
Genetic Map
Chromosome 14
33.34 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:63943706-63950732 bp, + strand
From NCBI annotation of GRCm38

  7027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOX7
Gene Tree: Sox7

Human
homologs
SOX7, SRY (sex determining region Y)-box 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 83595
neXtProt AC: NX_Q9BT81

Human Chr (Location): 8p23.1; chr8:10723768-10730574 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Most embryos homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal vitelline vascular remodeling and pericardial edema, and die during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital retrosternal diaphragmatic hernias.
 
Human Diseases Modeled in Mice Using Sox7 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sox7 interacts with 299 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process endoderm formation, negative regulation of cell proliferation, ...
Component cytoplasm, nucleus
Function DNA binding, sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (257)    Tissues (171)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
RT-PCR 104
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX7 ; Xenbase sox7 ; ZFIN sox7    NEW 
Molecular
reagents
All nucleic(24) cDNA(20) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000063060 (Evidence)
Entrez Gene 20680 (Evidence)
UniGene 42162
DFCI TC1579935, TC1594816
DoTS DT.50315687, DT.55248834
NIA Mouse Gene Index U015758
Consensus CDS Project CCDS27206.1
International Mouse Phenotyping Consortium Status Sox7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified 
polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group box domain
InterPro IPR021934 Sox C-terminal transactivation domain
Protein Ontology PR:000015433 transcription factor SOX-7
Graphical View of Protein Domain Structure
References
(Earliest) J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
(Latest) J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305
All references(59)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory