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Sox7
Gene Detail
 Symbol
Name
ID
Sox7
SRY (sex determining region Y)-box 7
MGI:98369
Feature Type protein coding gene
Genetic Map
Chromosome 14
33.34 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:63943706-63950732 bp, + strand
From NCBI annotation of GRCm38

  7027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sox7

Human
homologs
Human Homolog SOX7, SRY (sex determining region Y)-box 7
NCBI Gene ID 83595
neXtProt AC  NX_Q9BT81
Human Chr (Location)  8p23.1; chr8:10723768-10730574 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Most embryos homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal vitelline vascular remodeling and pericardial edema, and die during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital retrosternal diaphragmatic hernias.
 
Human Diseases Modeled Using Mouse Sox7 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sox7 interacts with 299 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process endoderm formation, negative regulation of cell proliferation, ...
Component cytoplasm, nucleus
Function DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (257)    Tissues (171)    Images (17)
Theiler Stages: 2, 3, 4, 5, 10, 11, 15, 17, 18, 20, 21, 23, 26, 27, 28
Assay TypeResults
RNA in situ 153
RT-PCR 104
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(20) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000063060 (Evidence)
Entrez Gene20680 (Evidence)
UniGene42162
DFCITC1579935, TC1594816
DoTSDT.50315687, DT.55248834
NIA Mouse Gene IndexU015758
Consensus CDS ProjectCCDS27206.1
International Mouse Knockout Project StatusSox7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified 
polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR021934 Sox C-terminal transactivation domain
Protein Ontology PR:000015433 transcription factor SOX-7
Graphical View of Protein Domain Structure
References (Earliest) J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
(Latest) J:198640 Frum T, et al., Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell. 2013 Jun 24;25(6):610-22
All references(56)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory