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Sox7 Gene Detail
Summary
  • Symbol
    Sox7
  • Name
    SRY (sex determining region Y)-box 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98369
    NCBI Gene: 20680
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63943706-63950732 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.34 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98369
protein coding gene Chr14:63943673-63950732 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021466
protein coding gene Chr14:58497271-58504331 (+)
A/J MGP_AJ_G0021425
protein coding gene Chr14:57155776-57162832 (+)
AKR/J MGP_AKRJ_G0021401
protein coding gene Chr14:59178949-59186005 (+)
BALB/cJ MGP_BALBcJ_G0021431
protein coding gene Chr14:57113388-57120446 (+)
C3H/HeJ MGP_C3HHeJ_G0021208
protein coding gene Chr14:58799621-58806681 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021870
protein coding gene Chr14:61238383-61245441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019410
protein coding gene Chr14:55091317-55098315 (+)
CAST/EiJ MGP_CASTEiJ_G0020725
protein coding gene Chr14:55256394-55276397 (+)
CBA/J MGP_CBAJ_G0021175
protein coding gene Chr14:63083893-63090951 (+)
DBA/2J MGP_DBA2J_G0021298
protein coding gene Chr14:56829524-56836584 (+)
FVB/NJ MGP_FVBNJ_G0021277
protein coding gene Chr14:56213633-56220679 (+)
LP/J MGP_LPJ_G0021373
protein coding gene Chr14:59531917-59538977 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021306
protein coding gene Chr14:62275335-62282393 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021893
protein coding gene Chr14:58337229-58344287 (+)
PWK/PhJ MGP_PWKPhJ_G0020469
protein coding gene Chr14:53506995-53547548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020302
protein coding gene Chr14:54302417-54321573 (+)
WSB/EiJ MGP_WSBEiJ_G0020778
protein coding gene Chr14:58655869-58662922 (+)



Homology
more
  • Human Ortholog
    SOX7, SRY-box 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX7, SRY-box 7
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 83595
    neXtProt AC: NX_Q9BT81
    UniProt: Q9BT81

  • Chr Location
    8p23.1; chr8:10723768-10730574 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7949
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SOX7
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sox7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most embryos homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal vitelline vascular remodeling and pericardial edema, and die during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital retrosternal diaphragmatic hernias.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
    transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified  
    polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR033392 Sox 7/17/18, central domain
      IPR021934 Sox, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 22
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14508
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:265463 Igarashi H, et al., Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk. Biol Reprod. 2018 Sep 1;99(3):578-589

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory