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Sox7 Gene Detail
Summary
  • Symbol
    Sox7
  • Name
    SRY (sex determining region Y)-box 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98369
    NCBI Gene: 20680
Location & Maps
more
  • Sequence Map
    Chr14:63943706-63950732 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7027 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.34 cM, cytoband C3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SOX7, SRY-box 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX7, SRY-box 7
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 83595
    neXtProt AC: NX_Q9BT81

  • Chr Location
    8p23.1; chr8:10723768-10730574 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7949
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SOX7
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sox7 mouse models

Human Disease Mouse Models
       Diaphragmatic Hernia, Congenital   OMIM: 142340 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Sox7
  • Incidental Mutations
Most embryos homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal vitelline vascular remodeling and pericardial edema, and die during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital retrosternal diaphragmatic hernias.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified  
polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR033392 Sox 7/17/18, central domain
    IPR021934 Sox, C-terminal
Molecular
Reagents
less
  • All nucleic 25
    cDNA 21
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14508
References
more
  • Summaries
    All 57
    Developmental Gene Expression 31
    Diseases 1
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
  • Latest
    J:229536 Kawasaki K, et al., Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59(10-12):471-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory