About   Help   FAQ
Sox7 Gene Detail
Summary
  • Symbol
    Sox7
  • Name
    SRY (sex determining region Y)-box 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98369
    NCBI Gene: 20680
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64181155-64188181 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.34 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98369
 protein coding gene Chr14:64181122-64188181 (+)
129S1/SvImJ ENSMUSG00200026806
 protein coding gene Chr14:52800759-52807820 (+)
A/J ENSMUSG00195014493
 protein coding gene Chr14:52979931-52986992 (+)
AKR/J ENSMUSG00220028203
 protein coding gene Chr14:52320438-52327499 (+)
BALB/cJ ENSMUSG00180032920
 protein coding gene Chr14:52596068-52603129 (+)
C3H/HeJ ENSMUSG00175034459
 protein coding gene Chr14:54337131-54344192 (+)
C57BL/6NJ ENSMUSG00215015825
 protein coding gene Chr14:52513740-52520799 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019410
 protein coding gene Chr14:55091317-55098315 (+)
CAST/EiJ ENSTCUG00005035682
 protein coding gene Chr14:54236597-54243636 (+)
CBA/J ENSMUSG00210037777
 protein coding gene Chr14:52967394-52974453 (+)
DBA/2J ENSMUSG00185029940
 protein coding gene Chr14:58134943-58142004 (+)
FVB/NJ ENSMUSG00205024627
 protein coding gene Chr14:52482800-52489859 (+)
JF1/MsJ ENSUMUG00000043411
 protein coding gene Chr14:69309206-69316279 (+)
LP/J ENSMUSG00230033409
 protein coding gene Chr14:70164385-70171446 (+)
NOD/ShiLtJ ENSMUSG00190027462
 protein coding gene Chr14:52762151-52769210 (+)
NZO/HlLtJ ENSMUSG00225044466
 protein coding gene Chr14:60495139-60502198 (+)
PWK/PhJ ENSLUMG00010034445
 protein coding gene Chr14:52192863-52199942 (+)
SPRET/EiJ ENSMSPG00010026910
 protein coding gene Chr14:55672371-55679457 (+)
WSB/EiJ ENSIUOG00005037151
 protein coding gene Chr14:52199481-52206535 (+)



Homology
more
  • Human Ortholog
    SOX7, SRY-box transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX7, SRY-box transcription factor 7
  • Links
    NCBI Gene ID: 83595
    UniProt: Q9BT81

  • Chr Location
    8p23.1; chr8:10723768-10730511 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sox7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele exhibit growth retardation, abnormal vitelline vascular remodeling, pericardial edema, hypocellular atrioventricular endocardial cushions, and death during organogenesis. Depending on the genetic background, a portion of heterozygotes can develop congenital diaphragmatic hernias.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    210
  • cDNA Data
    22
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20680 NCBI Gene Model | MGI Sequence Detail 7027 C57BL/6J ±  kb
    transcript NM_011446 RefSeq | MGI Sequence Detail 3266 Not Specified  
    polypeptide P40646 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 23
      Primer pair 9
      Other 3
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14508
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 55
      Diseases 1
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:361578 Feng W, et al., Deficiency of Sox7 leads to congenital aortic stenosis via abnormal valve remodeling. J Mol Cell Cardiol. 2025 Feb;199:81-94
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory