Sox15 MGI Mouse Gene Detail - MGI:98363 - SRY (sex determining region Y)-box 15

Sox15 Gene Detail

Symbol

Sox15
Name

SRY (sex determining region Y)-box 15

Feature Type

protein coding gene
IDs

MGI:98363
NCBI Gene: 20670
Gene Overview

MyGene.info: SOX15

Sequence Map

Chr11:69655314-69656727 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

1414 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM
Mapping Data

1 experiment

Human Ortholog

SOX15, SRY-box 15

Vertebrate Orthologs

5

Human Ortholog

SOX15, SRY-box 15
Orthology source: HomoloGene, HGNC
Synonyms

SOX20, SOX26, SOX27
Links

HGNC:11196

NCBI Gene ID: 6665

neXtProt AC: NX_O60248
Chr Location

17p13.1; chr17:7588180-7590170 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 74586
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog
HCOP

human homology predictions: SOX15
Gene Tree

Sox15

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Gene trapped

5
Targeted

4
Genomic Mutations

2 involving Sox15

Mice homozygous for disruptions in this gene display abnormalities in muscle fiber differentiation and in muscle regeneration after injury.

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All GO Annotations

24
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

160
Tissues

94
cDNA Data

10
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase sox15

ZFIN sox19a, sox19b

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Sox15 interacts with 24 markers (Mir23b, Mir33, Mir122, ...) View All

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All Sequences

22
RefSeq

2
UniProt

2
CCDS

CCDS24902.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005991	VEGA Gene Model \| MGI Sequence Detail	1414	C57BL/6J	± kb
transcript	OTTMUST00000013405	VEGA \| MGI Sequence Detail	861	Not Applicable
polypeptide	OTTMUSP00000006208	VEGA \| MGI Sequence Detail	231	Not Applicable

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SNPs within 2kb

42 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000015423 protein SOX-15
InterPro Domains

IPR009071 High mobility group box domain

IPR031269 Protein SOX-15

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All nucleic 17

Genomic 2

cDNA 10

Primer pair 5

Microarray probesets 2

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MGD-MRK-14502

Summaries

All 39

Developmental Gene Expression 14

Gene Ontology 7

Phenotypes 15
Earliest

J:4617 van de Wetering M, et al., Sox 15, a novel member of the murine Sox family of HMG box transcription factors. Nucleic Acids Res. 1993 Apr 11;21(7):1669
Latest

J:197716 Ng CK, et al., Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012 Jun;40(11):4933-41

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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