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Sox15 Gene Detail
Summary
  • Symbol
    Sox15
  • Name
    SRY (sex determining region Y)-box 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:98363
    NCBI Gene: 20670
  • Gene Overview
    MyGene.info: SOX15
Location & Maps
more
  • Sequence Map
    Chr11:69655314-69656727 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SOX15, SRY-box 15
  • Vertebrate Orthologs
    5
  • Human Ortholog
    SOX15, SRY-box 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SOX20, SOX26, SOX27
  • Links
    NCBI Gene ID: 6665
    neXtProt AC: NX_O60248

  • Chr Location
    17p13.1; chr17:7588180-7590170 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    4
  • Genomic Mutations
    2 involving Sox15
Mice homozygous for disruptions in this gene display abnormalities in muscle fiber differentiation and in muscle regeneration after injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005991 VEGA Gene Model | MGI Sequence Detail 1414 C57BL/6J ±  kb
transcript OTTMUST00000013405 VEGA | MGI Sequence Detail 861 Not Applicable  
polypeptide OTTMUSP00000006208 VEGA | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 10
    Primer pair 5

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14502
References
more
  • Summaries
    All 39
    Developmental Gene Expression 14
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:4617 van de Wetering M, et al., Sox 15, a novel member of the murine Sox family of HMG box transcription factors. Nucleic Acids Res. 1993 Apr 11;21(7):1669
  • Latest
    J:197716 Ng CK, et al., Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012 Jun;40(11):4933-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory