Sox15
Gene Detail

Symbol

Name
ID

Sox15
SRY (sex determining region Y)-box 15
MGI:98363

Feature Type

protein coding gene

Genetic Map

Chromosome 11
42.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:69655314-69656727 bp, + strand From VEGA annotation of GRCm38   1414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:74586  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Sox15

Human
homologs

Human Homolog		SOX15, SRY (sex determining region Y)-box 15
NCBI Gene ID		6665
neXtProt AC		NX_O60248
Human Synonyms		SOX20, SOX26, SOX27
Human Chr (Location)		17p13.1; chr17:7588180-7590170 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Genomic Mutations involving Sox15 (1)
 

Mice homozygous for disruptions in this gene display abnormalities in muscle fiber differentiation and in muscle regeneration after injury.

 

Interactions

Sox15 interacts with 24 markers (Mir23b, Mir33, Mir122, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	cell differentiation, myoblast development, ...
Component	cytoplasm, nuclear transcription factor complex, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)

Data Summary: Results (159)    Tissues (92)    Images (21)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	4
RNA in situ	40
RT-PCR	115

cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(17) Genomic(2) cDNA(10) Primer pair(5)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000005991 (Evidence)
Ensembl Gene Model	ENSMUSG00000041287 (Evidence)
Entrez Gene	20670 (Evidence)
Consensus CDS Project	CCDS24902.1
International Mouse Knockout Project Status	Sox15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005991	VEGA Gene Model | MGI Sequence Detail	1414	C57BL/6J
transcript	OTTMUST00000013405	VEGA | MGI Sequence Detail	861	Not Applicable
polypeptide	OTTMUSP00000006208	VEGA | MGI Sequence Detail	231	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(42 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR009071	High mobility group (HMG) box domain
Protein Ontology	PR:000015423	protein SOX-15

References

(Earliest) J:4617 van de Wetering M, et al., Sox 15, a novel member of the murine Sox family of HMG box transcription factors. Nucleic Acids Res. 1993 Apr 11;21(7):1669
(Latest) J:197716 Ng CK, et al., Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012 Jun;40(11):4933-41
All references(40)

Other
accession IDs

MGD-MRK-14502