Sox15 MGI Mouse Gene Detail - MGI:98363 - SRY (sex determining region Y)-box 15

Symbol

Sox15
Name

SRY (sex determining region Y)-box 15

Feature Type

protein coding gene
IDs

MGI:98363
NCBI Gene: 20670
Gene Overview

MyGene.info: SOX15
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:69655314-69656727 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM
Mapping Data

1 experiment

SNPs within 2kb

42 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98363	protein coding gene	Chr11:69655037-69656727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018543	protein coding gene	Chr11:70112257-70113670 (+)
A/J	MGP_AJ_G0018511	protein coding gene	Chr11:67471316-67472729 (+)
AKR/J	MGP_AKRJ_G0018480	protein coding gene	Chr11:69480109-69481522 (+)
BALB/cJ	MGP_BALBcJ_G0018483	protein coding gene	Chr11:67781051-67782464 (+)
C3H/HeJ	MGP_C3HHeJ_G0018296	protein coding gene	Chr11:69500672-69502085 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018934	protein coding gene	Chr11:72233167-72234580 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016579	protein coding gene	Chr11:64390423-64391837 (+)
CAST/EiJ	MGP_CASTEiJ_G0017851	protein coding gene	Chr11:69752092-69753505 (+)
CBA/J	MGP_CBAJ_G0018269	protein coding gene	Chr11:75466320-75467733 (+)
DBA/2J	MGP_DBA2J_G0018378	protein coding gene	Chr11:67053013-67054426 (+)
FVB/NJ	MGP_FVBNJ_G0018368	protein coding gene	Chr11:66689212-66690625 (+)
LP/J	MGP_LPJ_G0018448	protein coding gene	Chr11:70677890-70679303 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018391	protein coding gene	Chr11:76062255-76063668 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018976	protein coding gene	Chr11:69742869-69744282 (+)
PWK/PhJ	MGP_PWKPhJ_G0017625	protein coding gene	Chr11:67702326-67703739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017415	protein coding gene	Chr11:69557126-69558539 (+)
WSB/EiJ	MGP_WSBEiJ_G0017905	protein coding gene	Chr11:69414616-69416029 (+)

Human Ortholog

SOX15, SRY-box transcription factor 15

Vertebrate Orthologs

5

Human Ortholog

SOX15, SRY-box transcription factor 15
Orthology source: HomoloGene, HGNC
Synonyms

SOX20, SOX26, SOX27
Links

HGNC:11196

NCBI Gene ID: 6665

neXtProt AC: NX_O60248

UniProt: O60248
Chr Location

17p13.1; chr17:7588180-7590170 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 74586
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog
HCOP

human homology predictions: SOX15
Gene Tree

Sox15

less

Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Gene trapped

5
Targeted

4
Genomic Mutations

2 involving Sox15
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display abnormalities in muscle fiber differentiation and in muscle regeneration after injury.

less

All GO Annotations

30
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

160
Tissues

94
cDNA Data

11
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sox15

ZFIN sox19a, sox19b

less

Sox15 interacts with 24 markers (Mir23b, Mir33, Mir122, ...) View All

less

All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS24902.1

Ensembl

ENSMUSG00000041287 (Evidence)
NCBI Gene

20670

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041287	Ensembl Gene Model \| MGI Sequence Detail	1414	C57BL/6J	± kb
transcript	ENSMUST00000047373	Ensembl \| MGI Sequence Detail	861	Not Applicable
polypeptide	ENSMUSP00000048524	Ensembl \| MGI Sequence Detail	231	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000015423 protein SOX-15

(term hierarchy)
InterPro Domains

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR031269 Protein SOX-15

less

All nucleic 18

Genomic 2

cDNA 11

Primer pair 5

Microarray probesets 2

less

MGD-MRK-14502

Summaries

All 50

Developmental Gene Expression 16

Gene Ontology 8

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:273632 Planells B, et al., Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202

TSS for Sox15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102497	Chr11:69654999-69655013 (+)	-308 bp
Tssr102498	Chr11:69655029-69655055 (+)	-272 bp
Tssr102499	Chr11:69655559-69655567 (+)	249 bp
Tssr102500	Chr11:69655584-69655608 (+)	282 bp
Tssr102501	Chr11:69655617-69655630 (+)	310 bp
Tssr102502	Chr11:69655711-69655733 (+)	408 bp
Tssr102503	Chr11:69655808-69655819 (+)	500 bp
Tssr102504	Chr11:69655840-69655857 (+)	535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/06/2019 MGI 6.14