About   Help   FAQ
Son Gene Detail
Summary
  • Symbol
    Son
  • Name
    Son DNA binding protein
  • Synonyms
    2900011L12Rik, mKIAA1019
  • Feature Type
    protein coding gene
  • IDs
    MGI:98353
    NCBI Gene: 20658
  • Gene Overview
    MyGene.info: SON
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91647824-91679195 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98353
protein coding gene Chr16:91647506-91679221 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023046
protein coding gene Chr16:92675284-92709731 (+)
A/J MGP_AJ_G0023014
protein coding gene Chr16:88340832-88373273 (+)
AKR/J MGP_AKRJ_G0022984
protein coding gene Chr16:91010592-91042208 (+)
BALB/cJ MGP_BALBcJ_G0023016
protein coding gene Chr16:88867966-88900363 (+)
C3H/HeJ MGP_C3HHeJ_G0022777
protein coding gene Chr16:91585637-91618457 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023463
protein coding gene Chr16:95668720-95701557 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020965
protein coding gene Chr16:86038201-86070515 (+)
CAST/EiJ MGP_CASTEiJ_G0022296
protein coding gene Chr16:92148320-92180574 (+)
CBA/J MGP_CBAJ_G0022746
protein coding gene Chr16:99757677-99792088 (+)
DBA/2J MGP_DBA2J_G0022880
protein coding gene Chr16:88244884-88277247 (+)
FVB/NJ MGP_FVBNJ_G0022854
protein coding gene Chr16:87369763-87401800 (+)
LP/J MGP_LPJ_G0022950
protein coding gene Chr16:92375384-92407127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022875
protein coding gene Chr16:104299538-104335919 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023481
protein coding gene Chr16:91530677-91562550 (+)
PWK/PhJ MGP_PWKPhJ_G0022041
protein coding gene Chr16:88423210-88456066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021871
protein coding gene Chr16:91091238-91125674 (+)
WSB/EiJ MGP_WSBEiJ_G0022348
protein coding gene Chr16:91774681-91806342 (+)



Homology
more
  • Human Ortholog
    SON, SON DNA binding protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SON, SON DNA binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BASS1, C21orf50, DBP-5, NREBP, SON3, TOKIMS
  • Links
    NCBI Gene ID: 6651
    neXtProt AC: NX_P18583
    UniProt: P18583

  • Chr Location
    21q22.11; chr21:33543038-33577514 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20658 NCBI Gene Model | MGI Sequence Detail 31372 C57BL/6J ±  kb
transcript NM_178880 RefSeq | MGI Sequence Detail 8451 C57BL/6  
polypeptide Q9QX47 UniProt | EBI | MGI Sequence Detail 2444 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 1
    cDNA 29
    Primer pair 2
    Other 2

    Microarray probesets 11
Other
Accession IDs
less
MGD-MRK-14487, MGI:1915461, MGI:2146338, MGI:2146586, MGI:2146715
References
more
  • Summaries
    All 57
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:12630 Cheng S, et al., GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm Genome. 1993;4(6):338-42
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory