Sstr1
Gene Detail

Symbol Name ID

Sstr1 somatostatin receptor 1 MGI:98327

Synonyms

Smstr1, Smstr-1, sst1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

25.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:58211772-58213887 bp, + strand From VEGA annotation of GRCm38   2116 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Sstr1 ± 2 cM)

Protein SuperFamily: somatostatin receptor
Gene Tree: Sstr1

Human ortholog

SSTR1 somatostatin receptor 1 NCBI Gene ID 6751
Human Synonyms: SRIF-2, SS1R, SS-1-R, SS1-R
Human Chr14:38677204-38682268 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice display abnormal eye electrophysiology. Mice homozygous for a second targeted mutation display hypoactivity.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	glutamate receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (271)    Tissues (102)    Images (37)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	28
In situ reporter (knock in)	67
RT-PCR	176

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(3) cDNA(5) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037022 (Evidence)
Ensembl Gene Model	ENSMUSG00000035431 (Evidence)
Entrez Gene	20605 (Evidence)
UniGene	278336
DFCI	TC1589416
DoTS	DT.91379145
NIA Mouse Gene Index	U013980
Consensus CDS Project	CCDS36456.1
International Mouse Knockout Project Status	Sstr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037022	VEGA Gene Model | MGI Sequence Detail	2116	C57BL/6J
transcript	OTTMUST00000095213	VEGA | MGI Sequence Detail	1752	Not Applicable
polypeptide	OTTMUSP00000053112	VEGA | MGI Sequence Detail	391	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000586	Somatostatin receptor
InterPro	IPR001116	Somatostatin receptor, type 1
Protein Ontology	PR:000001668	somatostatin receptor 1

References

(Earliest) J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
(Latest) J:190646 Bodmer D, et al., Somatostatin receptor types 1 and 2 in the developing Mammalian cochlea. Dev Neurosci. 2012;34(4):342-53
All references(55)

Other accession IDs

MGD-MRK-14454, MGD-MRK-14457