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Sst Gene Detail
Summary
  • Symbol
    Sst
  • Name
    somatostatin
  • Synonyms
    preprosomatostatin, Smst, SOM, SRIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:98326
    NCBI Gene: 20604
  • Gene Overview
    MyGene.info: SST
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:23889581-23890844 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1264 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 15.00 cM, cytoband cen-C3
  • Mapping Data
    39 experiments
Homology
more
  • Human Ortholog
    SST, somatostatin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SST, somatostatin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SMST
  • Links
    NCBI Gene ID: 6750
    neXtProt AC: NX_P61278
    UniProt: P61278

  • Chr Location
    3q27.3; chr3:187668906-187670413 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 819
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SST
  • Protein SuperFamily
  • Gene Tree
    Sst
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 6 alleles in 8 genetic backgrounds
    8 phenotypes from multigenic genotypes
    167 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels,gastric fundus hyperplasia and hyperacidity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20604 NCBI Gene Model | MGI Sequence Detail 1264 C57BL/6J ±  kb
    transcript NM_009215 RefSeq | MGI Sequence Detail 599 Not Specified  
    polypeptide P60041 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      28 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 7
      cDNA 38
      Primer pair 10
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14453
    References
    more
    • Summaries
      All 610
      Developmental Gene Expression 360
      Gene Ontology 6
      Phenotypes 167
    • Earliest
      J:7362 Shen LP, et al., Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71
    • Latest
      J:261722 Cheriyan J, et al., Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain. J Neurosci. 2018 May 16;38(20):4829-4839

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory