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Sst
Gene Detail
Symbol

Name
ID
Sst
somatostatin
MGI:98326
Synonyms
preprosomatostatin, Smst, SOM, SRIF
Feature Type
protein coding gene
Genetic Map
Chromosome 16
15.00 cM, cytoband cen-C3
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr16:23889581-23890844 bp, - strand
From NCBI annotation of GRCm38

  1264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: somatostatin
Gene Tree: Sst

Human
homologs
Human Homolog SST, somatostatin
NCBI Gene ID 6750
neXtProt AC  NX_P61278
Human Synonyms  SMST
Human Chr (Location)  3q28; chr3:187668906-187670413 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
 
Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels, gastric fundus hyperplasia and hyperacidity.
 
Interactions
Sst interacts with 29 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of cell migration
Component extracellular region, extracellular space, ...
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (275 records)
Data Summary: Results (329)    Tissues (206)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 202
RT-PCR 88
RNase protection 7
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(7) cDNA(38) Primer pair(10) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000004366 (Evidence)
Entrez Gene20604 (Evidence)
UniGene2453
DFCITC1578163
DoTSDT.491211
NIA Mouse Gene IndexU036926
Consensus CDS ProjectCCDS28080.1
International Mouse Knockout Project StatusSst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20604 NCBI Gene Model | MGI Sequence Detail 1264 C57BL/6J ±  kb
transcript NM_009215 RefSeq | MGI Sequence Detail 599 Not Specified 
polypeptide P60041 UniProt | EBI | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004250 Somatostatin
InterPro IPR018142 Somatostatin/Cortistatin, C-terminal
Protein Ontology PR:000015665 somatostatin
Graphical View of Protein Domain Structure
References
(Earliest) J:7362 Shen LP, et al., Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71
(Latest) J:211630 Zhu Y, et al., Genetically targeted binary labeling of retinal neurons. J Neurosci. 2014 Jun 4;34(23):7845-61
All references(392)
Other
accession IDs
MGD-MRK-14453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory