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Sst
Gene Detail
Symbol

Name
ID
Sst
somatostatin
MGI:98326
Synonyms
preprosomatostatin, Smst, SOM, SRIF
Feature Type
protein coding gene
Genetic Map
Chromosome 16
15.00 cM, cytoband cen-C3
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr16:23889581-23890844 bp, - strand
From NCBI annotation of GRCm38

  1264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: SST
Protein SuperFamily: somatostatin
Gene Tree: Sst

Human
homologs
SST, somatostatin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6750
neXtProt AC: NX_P61278

Human Synonyms: SMST

Human Chr (Location): 3q28; chr3:187668906-187670413 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
 
Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels, gastric fundus hyperplasia and hyperacidity.
 
Interactions
Sst interacts with 29 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell-cell signaling, cell surface receptor signaling pathway, ...
Component extracellular region, extracellular space, ...
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (299 records)
Data Summary: Results (348)    Tissues (213)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 45
RNA in situ 208
RT-PCR 88
RNase protection 7
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SST ; Xenbase sst ; ZFIN sst1.1, sst1.2    NEW 
Molecular
reagents
All nucleic(57) Genomic(7) cDNA(38) Primer pair(10) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000004366 (Evidence)
Entrez Gene 20604 (Evidence)
UniGene 2453
DFCI TC1578163
DoTS DT.491211
NIA Mouse Gene Index U036926
Consensus CDS Project CCDS28080.1
International Mouse Phenotyping Consortium Status Sst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20604 NCBI Gene Model | MGI Sequence Detail 1264 C57BL/6J ±  kb
transcript NM_009215 RefSeq | MGI Sequence Detail 599 Not Specified 
polypeptide P60041 UniProt | EBI | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004250 Somatostatin
InterPro IPR018142 Somatostatin/Cortistatin, C-terminal
Protein Ontology PR:000015665 somatostatin
Graphical View of Protein Domain Structure
References
(Earliest) J:7362 Shen LP, et al., Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71
(Latest) J:222637 Pedraza-Arevalo S, et al., Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels. Endocrinology. 2015 Jun;156(6):1958-64
All references(422)
Other
accession IDs
MGD-MRK-14453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory