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Muc19 Gene Detail
Summary
  • Symbol
    Muc19
  • Name
    mucin 19
  • Synonyms
    apomucin, sld
Location & Maps
more
  • Sequence Map
    Chr15:91838326-91934555 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96230 bp   ±  kb flank

  • Genome Browsers
Homology
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Human Diseases
more
  • Diseases
    1 with Muc19 mouse models

Human Disease Mouse Models
       Sjogren Syndrome   OMIM: 270150 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Muc19
  • Incidental Mutations
Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033381 VEGA Gene Model | MGI Sequence Detail 96230 C57BL/6J ±  kb
transcript NM_207243 RefSeq | MGI Sequence Detail 22806 NFS  
polypeptide Q6PZE0 UniProt | EBI | MGI Sequence Detail 7524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    459 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR002919 Trypsin Inhibitor-like, cysteine rich domain
    IPR014853 Uncharacterised domain, cysteine-rich
    IPR001846 von Willebrand factor, type D domain
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 10
    Genomic 1
    cDNA 5
    Primer pair 4

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-14437, MGI:98316
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Diseases 6
    Gene Ontology 10
    Phenotypes 37
  • Earliest
    J:9277 Hayashi Y, et al., A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation. Am J Pathol. 1988 Aug;132(2):187-91
  • Latest
    J:226909 Yamada A, et al., Impaired Expansion of Regulatory T Cells in a Neonatal Thymectomy-Induced Autoimmune Mouse Model. Am J Pathol. 2015 Nov;185(11):2886-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory