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Muc19
Gene Detail
Symbol

Name
ID
Muc19
mucin 19
MGI:2676278
Synonyms
apomucin, sld
Feature Type
protein coding gene
Genetic Map
Chromosome 15
46.14 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:91838326-91936388 bp, + strand
From VEGA annotation of GRCm38

  98063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Muc19
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(3)
Genomic Mutations involving Muc19 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization.
 
Human Diseases Modeled Using Mouse Muc19 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Muc19 interacts with 259 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (58)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RT-PCR 53
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(5) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033381 (Evidence)
Ensembl Gene ModelENSMUSG00000044021 (Evidence)
Entrez Gene239611 (Evidence)
DFCITC1578551
DoTSDT.91341324
NIA Mouse Gene IndexU186154
International Mouse Knockout Project StatusMuc19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033381 VEGA Gene Model | MGI Sequence Detail 98063 C57BL/6J ±  kb
transcript OTTMUST00000083796 VEGA | MGI Sequence Detail 3806 Not Applicable 
polypeptide OTTMUSP00000045074 VEGA | MGI Sequence Detail 1254 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(19)
Polymorphisms
SNPs within 2kb(528 from dbSNP Build 137)    SNPs within 2kb including multiple locations(588)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
References
(Earliest) J:9277 Hayashi Y, et al., A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation. Am J Pathol. 1988 Aug;132(2):187-91
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(35)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-14437, MGI:98316

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory