Shbg MGI Mouse Gene Detail - MGI:98295 - sex hormone binding globulin

Shbg Gene Detail

Symbol

Shbg
Name

sex hormone binding globulin

Feature Type

protein coding gene
IDs

MGI:98295
NCBI Gene: 20415
Gene Overview

MyGene.info: SHBG

Sequence Map

Chr11:69614804-69617905 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

3102 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM
Mapping Data

17 experiments

Human Ortholog

SHBG, sex hormone binding globulin

Vertebrate Orthologs

9

Human Ortholog

SHBG, sex hormone binding globulin
Orthology source: HomoloGene, HGNC
Synonyms

ABP, SBP, TEBG
Links

HGNC:10839

NCBI Gene ID: 6462

neXtProt AC: NX_P04278

UniProt: P04278
Chr Location

17p13.1; chr17:7614064-7633383 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 813
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SHBG
Protein SuperFamily

sex steroid-binding protein
Gene Tree

Shbg

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from multigenic genotypes
16 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Shbg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

5
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

3
Tissues

1
cDNA Data

4
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN shbg

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Shbg interacts with 31 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

21
RefSeq

6
UniProt

2
CCDS

CCDS24899.1
UniGene

1431

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005986	VEGA Gene Model \| MGI Sequence Detail	3102	C57BL/6J	± kb
transcript	OTTMUST00000013396	VEGA \| MGI Sequence Detail	1419	Not Applicable
polypeptide	OTTMUSP00000006202	VEGA \| MGI Sequence Detail	403	Not Applicable

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SNPs within 2kb

37 from dbSNP Build 142

PCR

1
RFLP

4

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UniProt

2 Sequences
Protein Ontology

PR:000014836 sex hormone-binding globulin

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain

IPR001791 Laminin G domain

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All nucleic 7

cDNA 4

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-14401

Summaries

All 51

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:232827 Saez-Lopez C, et al., SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development. Endocrinology. 2015 Dec;156(12):4571-81

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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