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Shbg Gene Detail
Summary
  • Symbol
    Shbg
  • Name
    sex hormone binding globulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98295
    NCBI Gene: 20415
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69505630-69508731 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98295
 protein coding gene Chr11:69501108-69508852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018540
 protein coding gene Chr11:70064259-70067360 (-)
A/J MGP_AJ_G0018508
 protein coding gene Chr11:67428506-67432285 (-)
AKR/J MGP_AKRJ_G0018477
 protein coding gene Chr11:69439733-69442834 (-)
BALB/cJ MGP_BALBcJ_G0018480
 protein coding gene Chr11:67739164-67742265 (-)
C3H/HeJ MGP_C3HHeJ_G0018293
 protein coding gene Chr11:69458262-69461363 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018931
 protein coding gene Chr11:72189171-72192272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016576
 protein coding gene Chr11:64351015-64354109 (-)
CAST/EiJ MGP_CASTEiJ_G0017848
 protein coding gene Chr11:69702648-69705746 (-)
CBA/J MGP_CBAJ_G0018266
 protein coding gene Chr11:75416129-75419230 (-)
DBA/2J MGP_DBA2J_G0018375
 protein coding gene Chr11:67011202-67014264 (-)
FVB/NJ MGP_FVBNJ_G0018365
 protein coding gene Chr11:66647526-66650624 (-)
LP/J MGP_LPJ_G0018445
 protein coding gene Chr11:70633575-70636675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018388
 protein coding gene Chr11:76017035-76020136 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018973
 protein coding gene Chr11:69696509-69699718 (-)
PWK/PhJ MGP_PWKPhJ_G0017622
 protein coding gene Chr11:67659710-67662787 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017412
 protein coding gene Chr11:69512115-69515447 (-)
WSB/EiJ MGP_WSBEiJ_G0017902
 protein coding gene Chr11:69369245-69372346 (-)



Homology
more
  • Human Ortholog
    SHBG, sex hormone binding globulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHBG, sex hormone binding globulin
  • Synonyms
    ABP, SBP, TEBG
  • Links
    NCBI Gene ID: 6462
    UniProt: P04278

  • Chr Location
    17p13.1; chr17:7613946-7633382 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SHBG associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    6
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005202 Ensembl Gene Model | MGI Sequence Detail 3102 C57BL/6J ±  kb
transcript ENSMUST00000005334 Ensembl | MGI Sequence Detail 1419 Not Applicable  
polypeptide ENSMUSP00000005334 Ensembl | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 6
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14401
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory