Scg5
Gene Detail

Symbol Name ID

Scg5 secretogranin V MGI:98289

Synonyms

7B2, Sgne1, Sgne-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

57.45 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr2:113776362-113829121 bp, - strand From VEGA annotation of GRCm38   52760 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:130635  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque

Protein SuperFamily: neuroendocrine protein 7B2
Gene Tree: Scg5

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene often die before weaning and display a variety of metabolic defects.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	intracellular protein transport, negative regulation of catalytic activity, ...
Component	extracellular region, secretory granule
Function	enzyme inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (176)    Tissues (37)    Images (37)
Theiler Stages: 2, 3, 4, 5, 11, 13, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	167
RT-PCR	9

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019161 (Evidence)
Ensembl Gene Model	ENSMUSG00000023236 (Evidence)
Entrez Gene	20394 (Evidence)
UniGene	4836
DFCI	TC1574793, TC1732312
DoTS	DT.101131168, DT.50316846, DT.97409528
Consensus CDS Project	CCDS16561.1
International Mouse Knockout Project Status	Scg5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019161	VEGA Gene Model | MGI Sequence Detail	52760	C57BL/6J
transcript	OTTMUST00000036027	VEGA | MGI Sequence Detail	1208	Not Applicable
polypeptide	OTTMUSP00000016183	VEGA | MGI Sequence Detail	212	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(206 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007945	Neuroendocrine 7B2 precursor
Protein Ontology	PR:000014504	neuroendocrine protein 7B2

References

(Earliest) J:22953 Mbikay M, et al., cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. Int J Pept Protein Res. 1989 Jan;33(1):39-45
(Latest) J:187649 Kanaya T, et al., The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol. 2012;13(8):729-36
All references(58)

Other accession IDs

MGD-MRK-14385, MGD-MRK-14386, MGI:2138903