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Scg5
Gene Detail
Symbol

Name
ID
Scg5
secretogranin V
MGI:98289
Synonyms
7B2, Sgne1, Sgne-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.45 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:113776362-113829121 bp, - strand
From VEGA annotation of GRCm38

  52760 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SCG5
Protein SuperFamily: neuroendocrine protein 7B2
Gene Tree: Scg5

Human
homologs
SCG5, secretogranin V
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6447
neXtProt AC: NX_P05408

Human Synonyms: 7B2, P7B2, SGNE1, SgV

Human Chr (Location): 15q13-q14; chr15:32641669-32697097 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene often die before weaning and display a variety of metabolic defects.
 
Interactions
Scg5 interacts with 120 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process intracellular protein transport, negative regulation of catalytic activity, ...
Component cell, extracellular region, ...
Function enzyme inhibitor activity, unfolded protein binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (172)    Tissues (34)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 167
RT-PCR 5
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase scg5 ; ZFIN scg5    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019161 (Evidence)
Ensembl Gene Model ENSMUSG00000023236 (Evidence)
Entrez Gene 20394 (Evidence)
UniGene 4836
DFCI TC1574793, TC1732312
DoTS DT.101131168, DT.50316846, DT.97409528
Consensus CDS Project CCDS16561.1
International Mouse Phenotyping Consortium Status Scg5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019161 VEGA Gene Model | MGI Sequence Detail 52760 C57BL/6J ±  kb
transcript OTTMUST00000036027 VEGA | MGI Sequence Detail 1208 Not Applicable 
polypeptide OTTMUSP00000016183 VEGA | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(318 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007945 Neuroendocrine 7B2 precursor
Protein Ontology PR:000014504 neuroendocrine protein 7B2
References
(Earliest) J:22953 Mbikay M, et al., cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. Int J Pept Protein Res. 1989 Jan;33(1):39-45
(Latest) J:187649 Kanaya T, et al., The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol. 2012;13(8):729-36
All references(56)
Other
accession IDs
MGD-MRK-14385, MGD-MRK-14386, MGI:2138903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory