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Srsf5 Gene Detail
Summary
  • Symbol
    Srsf5
  • Name
    serine and arginine-rich splicing factor 5
  • Synonyms
    Sfrs5
  • Feature Type
    protein coding gene
  • IDs
    MGI:98287
    NCBI Gene: 20384
  • Gene Overview
    MyGene.info: SRSF5
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80945504-80950507 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.20 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98287
protein coding gene Chr12:80945495-80950507 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019895
protein coding gene Chr12:81365523-81374026 (+)
A/J MGP_AJ_G0019853
protein coding gene Chr12:78388823-78395606 (+)
AKR/J MGP_AKRJ_G0019828
protein coding gene Chr12:80533738-80539878 (+)
BALB/cJ MGP_BALBcJ_G0019832
protein coding gene Chr12:78639668-78645408 (+)
C3H/HeJ MGP_C3HHeJ_G0019638
protein coding gene Chr12:81002643-81007747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020284
protein coding gene Chr12:83745565-83750568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017903
protein coding gene Chr12:75381785-75387938 (+)
CAST/EiJ MGP_CASTEiJ_G0019188
protein coding gene Chr12:75870682-75876423 (+)
CBA/J MGP_CBAJ_G0019609
protein coding gene Chr12:86999786-87010867 (+)
DBA/2J MGP_DBA2J_G0019724
protein coding gene Chr12:78000403-78006226 (+)
FVB/NJ MGP_FVBNJ_G0019710
protein coding gene Chr12:76824472-76829588 (+)
LP/J MGP_LPJ_G0019796
protein coding gene Chr12:81274648-81280995 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019749
protein coding gene Chr12:89998054-90003142 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020319
protein coding gene Chr12:80061835-80074843 (+)
PWK/PhJ MGP_PWKPhJ_G0018954
protein coding gene Chr12:72400662-72405866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018748
protein coding gene Chr12:74582248-74589310 (+)
WSB/EiJ MGP_WSBEiJ_G0019241
protein coding gene Chr12:80706695-80711297 (+)



Homology
more
  • Human Ortholog
    SRSF5, serine and arginine rich splicing factor 5
  • Vertebrate Orthologs
    3
  • Human Ortholog
    SRSF5, serine and arginine rich splicing factor 5
    Orthology source: HGNC
  • Synonyms
    HRS, SFRS5, SRP40
  • Links
    NCBI Gene ID: 6430
    neXtProt AC: NX_Q13243
    UniProt: Q13243

  • Chr Location
    14q24.1; chr14:69767087-69772005 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021134 Ensembl Gene Model | MGI Sequence Detail 5004 C57BL/6J ±  kb
    transcript ENSMUST00000110354 Ensembl | MGI Sequence Detail 1489 Not Applicable  
    polypeptide ENSMUSP00000105983 Ensembl | MGI Sequence Detail 270 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014762 serine/arginine-rich splicing factor 5
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR035585 Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1
    Molecular
    Reagents
    less
    • All nucleic 492
      Genomic 5
      cDNA 486
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14375
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:45103 Du K, et al., Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Gene. 1997 Dec 19;204(1-2):243-9
    • Latest
      J:246964 Botti V, et al., Cellular differentiation state modulates the mRNA export activity of SR proteins. J Cell Biol. 2017 Jul 03;216(7):1993-2009

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory