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Srsf5 Gene Detail
Summary
  • Symbol
    Srsf5
  • Name
    serine/arginine-rich splicing factor 5
  • Synonyms
    Sfrs5
  • Feature Type
    protein coding gene
  • IDs
    MGI:98287
    NCBI Gene: 20384
  • Gene Overview
    MyGene.info: SRSF5
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80945504-80950507 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.20 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98287
 protein coding gene Chr12:80945504-80950507 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019895
 protein coding gene Chr12:81365523-81374026 (+)
A/J MGP_AJ_G0019853
 protein coding gene Chr12:78388823-78395606 (+)
AKR/J MGP_AKRJ_G0019828
 protein coding gene Chr12:80533738-80539878 (+)
BALB/cJ MGP_BALBcJ_G0019832
 protein coding gene Chr12:78639668-78645408 (+)
C3H/HeJ MGP_C3HHeJ_G0019638
 protein coding gene Chr12:81002643-81007747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020284
 protein coding gene Chr12:83745565-83750568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017903
 protein coding gene Chr12:75381785-75387938 (+)
CAST/EiJ MGP_CASTEiJ_G0019188
 protein coding gene Chr12:75870682-75876423 (+)
CBA/J MGP_CBAJ_G0019609
 protein coding gene Chr12:86999786-87010867 (+)
DBA/2J MGP_DBA2J_G0019724
 protein coding gene Chr12:78000403-78006226 (+)
FVB/NJ MGP_FVBNJ_G0019710
 protein coding gene Chr12:76824472-76829588 (+)
LP/J MGP_LPJ_G0019796
 protein coding gene Chr12:81274648-81280995 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019749
 protein coding gene Chr12:89998054-90003142 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020319
 protein coding gene Chr12:80061835-80074843 (+)
PWK/PhJ MGP_PWKPhJ_G0018954
 protein coding gene Chr12:72400662-72405866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018748
 protein coding gene Chr12:74582248-74589310 (+)
WSB/EiJ MGP_WSBEiJ_G0019241
 protein coding gene Chr12:80706695-80711297 (+)



Homology
more
  • Human Ortholog
    SRSF5, serine and arginine rich splicing factor 5
  • Vertebrate Orthologs
    3
  • Human Ortholog
    SRSF5, serine and arginine rich splicing factor 5
    Orthology source: HGNC
  • Synonyms
    HRS, SFRS5, SRP40
  • Links
    NCBI Gene ID: 6430
    neXtProt AC: NX_Q13243
    UniProt: Q13243

  • Chr Location
    14q24.1; chr14:69767087-69772005 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    28
  • Tissues
    28
  • cDNA Data
    486
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20384 NCBI Gene Model | MGI Sequence Detail 5004 C57BL/6J ±  kb
transcript NM_001079695 RefSeq | MGI Sequence Detail 1710 C57BL/6  
polypeptide O35326 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014762 serine/arginine-rich splicing factor 5
    (term hierarchy)
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR035585 Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1
Molecular
Reagents
less
  • All nucleic 492
    Genomic 5
    cDNA 486
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14375
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:45103 Du K, et al., Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Gene. 1997 Dec 19;204(1-2):243-9
  • Latest
    J:246964 Botti V, et al., Cellular differentiation state modulates the mRNA export activity of SR proteins. J Cell Biol. 2017 Jul 03;216(7):1993-2009
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/04/2019
MGI 6.14 		The Jackson Laboratory