Srsf5 MGI Mouse Gene Detail - MGI:98287 - serine and arginine-rich splicing factor 5

Symbol

Srsf5
Name

serine and arginine-rich splicing factor 5
Synonyms

Sfrs5

Feature Type

protein coding gene
IDs

MGI:98287
NCBI Gene: 20384
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr12:80992308-80997277 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 37.20 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98287	protein coding gene	Chr12:80992278-80997281 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019895	protein coding gene	Chr12:81365523-81374026 (+)
A/J	MGP_AJ_G0019853	protein coding gene	Chr12:78388823-78395606 (+)
AKR/J	MGP_AKRJ_G0019828	protein coding gene	Chr12:80533738-80539878 (+)
BALB/cJ	MGP_BALBcJ_G0019832	protein coding gene	Chr12:78639668-78645408 (+)
C3H/HeJ	MGP_C3HHeJ_G0019638	protein coding gene	Chr12:81002643-81007747 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020284	protein coding gene	Chr12:83745565-83750568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017903	protein coding gene	Chr12:75381785-75387938 (+)
CAST/EiJ	MGP_CASTEiJ_G0019188	protein coding gene	Chr12:75870682-75876423 (+)
CBA/J	MGP_CBAJ_G0019609	protein coding gene	Chr12:86999786-87010867 (+)
DBA/2J	MGP_DBA2J_G0019724	protein coding gene	Chr12:78000403-78006226 (+)
FVB/NJ	MGP_FVBNJ_G0019710	protein coding gene	Chr12:76824472-76829588 (+)
LP/J	MGP_LPJ_G0019796	protein coding gene	Chr12:81274648-81280995 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019749	protein coding gene	Chr12:89998054-90003142 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020319	protein coding gene	Chr12:80061835-80074843 (+)
PWK/PhJ	MGP_PWKPhJ_G0018954	protein coding gene	Chr12:72400662-72405866 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018748	protein coding gene	Chr12:74582248-74589310 (+)
WSB/EiJ	MGP_WSBEiJ_G0019241	protein coding gene	Chr12:80706695-80711297 (+)

Human Ortholog

SRSF5, serine and arginine rich splicing factor 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRSF5, serine and arginine rich splicing factor 5
Synonyms

HRS, SFRS5, SRP40
Links

HGNC:10787

NCBI Gene ID: 6430

UniProt: Q13243
Chr Location

14q24.1; chr14:69726900-69772005 (+) GRCh38

MGI Vertebrate Homology

Srsf5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SRSF5
Gene Tree

Srsf5

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Phenotype Summary

27 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

11
Targeted

1
Genomic Mutations

1 involving Srsf5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit noncompation of ventricular myocardium with most mice dying within 24 h of birth and all dying by P2.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

31
cDNA Data

486
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf5

ZFIN srsf5a, srsf5b

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All Sequences

82
RefSeq

20
UniProt

4
CCDS

CCDS36484.1, CCDS83974.1

Ensembl

ENSMUSG00000021134 (Evidence)
NCBI Gene

20384

			Length	Strain/Species	Flank
genomic	20384	NCBI Gene Model \| MGI Sequence Detail	4970	C57BL/6J	± kb
transcript	NM_001409837	RefSeq \| MGI Sequence Detail	1622	C57BL/6
polypeptide	O35326	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014762 serine/arginine-rich splicing factor 5

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR050374 RRT5/SRSF/Splicing Factor SR
GlyGen

O35326 1 site, 1 O-linked glycan (1 site)

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All nucleic 494

Genomic 5

cDNA 486

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-14375

Summaries

All 47

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 14
Earliest

J:45103 Du K, et al., Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Gene. 1997 Dec 19;204(1-2):243-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srsf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114179	Chr12:80992274-80992279 (+)	-31 bp
Tssr114180	Chr12:80992297-80992315 (+)	-2 bp
Tssr114181	Chr12:80992968-80992989 (+)	671 bp
Tssr114182	Chr12:80992990-80993000 (+)	687 bp
Tssr114183	Chr12:80993063-80993082 (+)	765 bp
Tssr114184	Chr12:80994248-80994293 (+)	1,963 bp
Tssr114185	Chr12:80995359-80995412 (+)	3,078 bp
Tssr114186	Chr12:80995416-80995428 (+)	3,114 bp
Tssr114187	Chr12:80995451-80995485 (+)	3,160 bp
Tssr114188	Chr12:80995525-80995529 (+)	3,219 bp
Tssr114189	Chr12:80995597-80995615 (+)	3,298 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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