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Srsf3 Gene Detail
Summary
  • Symbol
    Srsf3
  • Name
    serine/arginine-rich splicing factor 3
  • Synonyms
    Sfrs3, X16
  • Feature Type
    protein coding gene
  • IDs
    MGI:98285
    NCBI Gene: 20383
  • Gene Overview
    MyGene.info: SRSF3
Location & Maps
more
  • Sequence Map
    Chr17:29032673-29043366 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10694 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.03 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SRSF3, serine and arginine rich splicing factor 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SRSF3, serine and arginine rich splicing factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SFRS3, SRp20
  • Links
    NCBI Gene ID: 6428
    neXtProt AC: NX_P84103

  • Chr Location
    6p21; chr6:36594313-36604467 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    92
  • Gene trapped
    88
  • Targeted
    4
  • Incidental Mutations
Homozygous mutant mice die at early embryonic stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031658 VEGA Gene Model | MGI Sequence Detail 10694 C57BL/6J ±  kb
transcript OTTMUST00000078432 VEGA | MGI Sequence Detail 2566 Not Applicable  
polypeptide OTTMUSP00000041701 VEGA | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014760 serine/arginine-rich splicing factor 3
  • PDB
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 38
    Genomic 2
    cDNA 33
    Primer pair 1
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-14373, MGI:2146963
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
  • Latest
    J:213669 Wang Q, et al., Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression. Mol Cell Biol. 2014 May;34(10):1747-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory