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Sele
Gene Detail
 Symbol
Name
ID
Sele
selectin, endothelial cell
MGI:98278
Synonyms CD62E, Elam, E-selectin
Feature Type protein coding gene
Genetic Map
Chromosome 1
71.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:164048234-164057677 bp, + strand
From NCBI annotation of GRCm38

  9444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: E-selectin/P-selectin
Gene Tree: Sele

Human
homologs
Human Homolog SELE, selectin E
NCBI Gene ID 6401
neXtProt AC  NX_P16581
Human Synonyms  CD62E, ELAM, ELAM1, ESEL, LECAM2
Human Chr (Location)  1q22-q25; chr1:169722640-169734079 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SELE
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.
 
Interactions
Sele interacts with 168 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin filament-based process, activation of phospholipase C activity, ...
Component caveola, coated pit, ...
Function carbohydrate binding, oligosaccharide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(4) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026582 (Evidence)
Entrez Gene20339 (Evidence)
UniGene5245
DFCITC1593440
DoTSDT.91331373
NIA Mouse Gene IndexU001013
Consensus CDS ProjectCCDS15432.1
International Mouse Knockout Project StatusSele
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20339 NCBI Gene Model | MGI Sequence Detail 9444 C57BL/6J ±  kb
transcript NM_011345 RefSeq | MGI Sequence Detail 2912 C57BL/6 
polypeptide Q00690 UniProt | EBI | MGI Sequence Detail 612 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002396 Selectin superfamily
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001415 E-selectin
Graphical View of Protein Domain Structure
References (Earliest) J:10574 Watson ML, et al., Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990 Jul 1;172(1):263-72
(Latest) J:204363 Wicklein D, et al., E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. PLoS One. 2013;8(7):e70139
All references(158)
Other
accession IDs
MGD-MRK-14357, MGD-MRK-9356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory