About   Help   FAQ
Sele
Gene Detail
Symbol

Name
ID
Sele
selectin, endothelial cell
MGI:98278
Synonyms
CD62E, Elam, E-selectin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
71.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:164048216-164058486 bp, + strand
From VEGA annotation of GRCm38

  10271 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: SELE
Protein SuperFamily: E-selectin/P-selectin
Gene Tree: Sele

Human
homologs
SELE, selectin E
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6401
neXtProt AC: NX_P16581

Human Synonyms: CD62E, ELAM, ELAM1, ESEL, LECAM2

Human Chr (Location): 1q24.2; chr1:169722640-169734079 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SELE

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.
 
Interactions
Sele interacts with 167 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actin filament-based process, activation of phospholipase C activity, ...
Component caveola, coated pit, ...
Function carbohydrate binding, oligosaccharide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(4) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050836 (Evidence)
Ensembl Gene Model ENSMUSG00000026582 (Evidence)
Entrez Gene 20339 (Evidence)
UniGene 5245
DFCI TC1593440
DoTS DT.91331373
NIA Mouse Gene Index U001013
Consensus CDS Project CCDS15432.1
International Mouse Phenotyping Consortium Status Sele
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050836 VEGA Gene Model | MGI Sequence Detail 10271 C57BL/6J ±  kb
transcript OTTMUST00000128806 VEGA | MGI Sequence Detail 2912 Not Applicable 
polypeptide OTTMUSP00000069269 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002396 Selectin superfamily
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001415 E-selectin
References
(Earliest) J:10574 Watson ML, et al., Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990 Jul 1;172(1):263-72
(Latest) J:214895 Nabors LK, et al., Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow. Exp Hematol. 2013 Jul;41(7):588-96
All references(157)
Other
accession IDs
MGD-MRK-14357, MGD-MRK-9356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory