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Sele Gene Detail
Summary
  • Symbol
    Sele
  • Name
    selectin, endothelial cell
  • Synonyms
    CD62E, Elam, E-selectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98278
    NCBI Gene: 20339
  • Gene Overview
    MyGene.info: SELE
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:164048234-164057677 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 71.35 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98278
protein coding gene Chr1:164039614-164058487 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016677
protein coding gene Chr1:169460608-169470147 (+)
A/J MGP_AJ_G0016658
protein coding gene Chr1:162557575-162567008 (+)
AKR/J MGP_AKRJ_G0016624
protein coding gene Chr1:167489348-167498763 (+)
BALB/cJ MGP_BALBcJ_G0016619
protein coding gene Chr1:163058715-163068131 (+)
C3H/HeJ MGP_C3HHeJ_G0016443
protein coding gene Chr1:167671572-167680997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017080
protein coding gene Chr1:175163461-175172898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014789
protein coding gene Chr1:154543464-154552853 (+)
CAST/EiJ MGP_CASTEiJ_G0016023
protein coding gene Chr1:167310959-167321546 (+)
CBA/J MGP_CBAJ_G0016418
protein coding gene Chr1:181393218-181402658 (+)
DBA/2J MGP_DBA2J_G0016524
protein coding gene Chr1:161452869-161462352 (+)
FVB/NJ MGP_FVBNJ_G0016522
protein coding gene Chr1:159904430-159913867 (+)
LP/J MGP_LPJ_G0016595
protein coding gene Chr1:170542279-170551728 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016547
protein coding gene Chr1:188905304-188919578 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017116
protein coding gene Chr1:167316123-167325521 (+)
PWK/PhJ MGP_PWKPhJ_G0015809
protein coding gene Chr1:160642526-160652289 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015596
protein coding gene Chr1:166193223-166202785 (+)
WSB/EiJ MGP_WSBEiJ_G0016085
protein coding gene Chr1:167481086-167490500 (+)



Homology
more
  • Human Ortholog
    SELE, selectin E
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SELE, selectin E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD62E, ELAM, ELAM1, ESEL, LECAM2
  • Links
    NCBI Gene ID: 6401
    neXtProt AC: NX_P16581
    UniProt: P16581

  • Chr Location
    1q24.2; chr1:169722640-169734079 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 9 genetic backgrounds
    52 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026582 Ensembl Gene Model | MGI Sequence Detail 9444 C57BL/6J ±  kb
    transcript ENSMUST00000027874 Ensembl | MGI Sequence Detail 2912 Not Applicable  
    polypeptide ENSMUSP00000027874 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 4
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14357, MGD-MRK-9356
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 101
    • Earliest
      J:10574 Watson ML, et al., Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990 Jul 1;172(1):263-72
    • Latest
      J:269006 Casanova-Acebes M, et al., Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med. 2018 Nov 5;215(11):2778-2795

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory