Sele MGI Mouse Gene Detail - MGI:98278 - selectin, endothelial cell

Symbol

Sele
Name

selectin, endothelial cell
Synonyms

CD62E, Elam, E-selectin

Feature Type

protein coding gene
IDs

MGI:98278
NCBI Gene: 20339
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:163875773-163885246 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 71.35 cM
Mapping Data

11 experiments

SNPs within 2kb

152 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98278	protein coding gene	Chr1:163867200-163886056 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016677	protein coding gene	Chr1:169460608-169470147 (+)
A/J	MGP_AJ_G0016658	protein coding gene	Chr1:162557575-162567008 (+)
AKR/J	MGP_AKRJ_G0016624	protein coding gene	Chr1:167489348-167498763 (+)
BALB/cJ	MGP_BALBcJ_G0016619	protein coding gene	Chr1:163058715-163068131 (+)
C3H/HeJ	MGP_C3HHeJ_G0016443	protein coding gene	Chr1:167671572-167680997 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017080	protein coding gene	Chr1:175163461-175172898 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014789	protein coding gene	Chr1:154543464-154552853 (+)
CAST/EiJ	MGP_CASTEiJ_G0016023	protein coding gene	Chr1:167310959-167321546 (+)
CBA/J	MGP_CBAJ_G0016418	protein coding gene	Chr1:181393218-181402658 (+)
DBA/2J	MGP_DBA2J_G0016524	protein coding gene	Chr1:161452869-161462352 (+)
FVB/NJ	MGP_FVBNJ_G0016522	protein coding gene	Chr1:159904430-159913867 (+)
LP/J	MGP_LPJ_G0016595	protein coding gene	Chr1:170542279-170551728 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016547	protein coding gene	Chr1:188905304-188919578 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017116	protein coding gene	Chr1:167316123-167325521 (+)
PWK/PhJ	MGP_PWKPhJ_G0015809	protein coding gene	Chr1:160642526-160652289 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015596	protein coding gene	Chr1:166193223-166202785 (+)
WSB/EiJ	MGP_WSBEiJ_G0016085	protein coding gene	Chr1:167481086-167490500 (+)

Human Ortholog

SELE, selectin E

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SELE, selectin E
Synonyms

CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin-e
Links

HGNC:10718

NCBI Gene ID: 6401

neXtProt AC: NX_P16581

UniProt: P16581
Chr Location

1q24.2; chr1:169722640-169764705 (-) GRCh38

MGI Vertebrate Homology

Sele stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SELE
Gene Tree

Sele

Diseases

4 with human SELE associations

				Human Disease	Mouse Models
				brain ischemia IDs brain ischemia DOID:2316 MESH:D002545 UMLS_CUI:C0007786
				cerebrovascular disease IDs cerebrovascular disease DOID:6713 DOID:12214 DOID:3455 DOID:8231 EFO:0000712 ICD10CM:I67.9 ICD9CM:430-438.99 ICD9CM:437.9 MESH:D002561 NCI:C2938 UMLS_CUI:C0007820
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 4 alleles in 9 genetic backgrounds
54 phenotypes from multigenic genotypes
107 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

10
Genomic Mutations

2 involving Sele
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit mild defects in neutrophil infiltration during inflammatory responses. When combined with other selectin gene knockouts, more severe defects are present.

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All GO Annotations

38
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

48
cDNA Data

8
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN sele

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All Sequences

36
RefSeq

6
UniProt

2
CCDS

CCDS15432.1

Ensembl

ENSMUSG00000026582 (Evidence)
NCBI Gene

20339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026582	Ensembl Gene Model \| MGI Sequence Detail	9474	C57BL/6J	± kb
transcript	ENSMUST00000027874	Ensembl \| MGI Sequence Detail	2942	Not Applicable
polypeptide	ENSMUSP00000027874	Ensembl \| MGI Sequence Detail	612	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001415 E-selectin

(term hierarchy)
InterPro Domains

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR033991 Selectin, C-type lectin-like domain

IPR002396 Selectin superfamily

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 16

Genomic 4

cDNA 10

Primer pair 2

Microarray probesets 3

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MGD-MRK-14357, MGD-MRK-9356

Summaries

All 188

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 107
Earliest

J:10574 Watson ML, et al., Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990 Jul 1;172(1):263-72
Latest

J:343584 Zhang J, et al., Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG. J Immunol. 2023 Dec 15;211(12):1835-1843

TSS for Sele:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9743	Chr1:163875783-163875785 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23