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Sds Gene Detail
Summary
  • Symbol
    Sds
  • Name
    serine dehydratase
  • Synonyms
    SDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:98270
    NCBI Gene: 231691
Location & Maps
more
  • Sequence Map
    Chr5:120476526-120483932 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SDS, serine dehydratase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SDS, serine dehydratase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SDH
  • Links
    NCBI Gene ID: 10993
    neXtProt AC: NX_P20132

  • Chr Location
    12q24.13; chr12:113392445-113403887 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Sds
  • Incidental Mutations
    APF
Sds is the serine dehydratase structural gene. Albino region deletions profoundly affect development and expression of some gluconeogenic enzymes, including Sds. In these deletion mice, Sds is expressed normally on the constitutive level, but fails to develop hormone-inducible expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025315 VEGA Gene Model | MGI Sequence Detail 7407 C57BL/6J ±  kb
transcript OTTMUST00000062308 VEGA | MGI Sequence Detail 1207 Not Applicable  
polypeptide OTTMUSP00000030698 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 60
    Genomic 5
    cDNA 52
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-14347
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:64 Lia M, et al., Regulatory genes linked to the albino locus in the mouse confer competence for inducible expression on the structural gene encoding serine dehydratase. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2453-5
  • Latest
    J:178360 Zhang M, et al., Disruption of beta-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice. Mech Dev. 2011 Sep;128(7-10):368-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory