Sord MGI Mouse Gene Detail - MGI:98266

Sord Gene Detail

Symbol

Sord
Name

sorbitol dehydrogenase
Synonyms

Sdh1, Sdh-1, Sodh-1

Feature Type

protein coding gene
IDs

MGI:98266
NCBI Gene: 20322
Gene Overview

MyGene.info: SORD

Sequence Map

Chr2:122234749-122265340 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

30592 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.59 cM
Mapping Data

6 experiments

Human Ortholog

SORD, sorbitol dehydrogenase

Vertebrate Orthologs

10

Human Ortholog

SORD, sorbitol dehydrogenase
Orthology source: HomoloGene, HGNC
Synonyms

HEL-S-95n, SORD1
Links

HGNC:11184

NCBI Gene ID: 6652

neXtProt AC: NX_Q00796
Chr Location

15q15.3; chr15:45023104-45075089 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 56080
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SORD
Protein SuperFamily

alcohol dehydrogenase
Gene Tree

Sord

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Phenotype Summary

3 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

2 involving Sord
Incidental Mutations

APF , CvDC

Mice homozygous for a functional null allele found in strain C57BL/LiA exhibit no obvious abnormalities in the kidney or other physiological systems. An additional isoelectric focusing variant is found in Peru stocks and has about 25% of the activity of that in most inbred strains.

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All GO Annotations

27
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

270
Tissues

270
cDNA Data

19
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase sord

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Sord interacts with 161 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

46
RefSeq

2
UniProt

1
CCDS

CCDS16657.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015564	VEGA Gene Model \| MGI Sequence Detail	30592	C57BL/6J	± kb
transcript	OTTMUST00000036985	VEGA \| MGI Sequence Detail	2352	Not Applicable
polypeptide	OTTMUSP00000016594	VEGA \| MGI Sequence Detail	357	Not Applicable

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SNPs within 2kb

280 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000015410 sorbitol dehydrogenase
EC

1.1.1.14
InterPro Domains

IPR013149 Alcohol dehydrogenase, C-terminal

IPR013154 Alcohol dehydrogenase, N-terminal

IPR002085 Alcohol dehydrogenase superfamily, zinc-type

IPR002328 Alcohol dehydrogenase, zinc-type, conserved site

IPR011032 GroES-like

IPR016040 NAD(P)-binding domain

IPR020843 Polyketide synthase, enoylreductase domain

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 3

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MGD-MRK-14340, MGD-MRK-14341, MGD-MRK-35108

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 13
Earliest

J:12039 Holmes RS, et al., Genetic variation, cellular distribution and ontogeny of sorbitol dehydrogenase and alcohol dehydrogenase isozymes in male reproductive tissues of the mouse. J Exp Zool. 1978 Nov;206(2):279-88
Latest

J:222615 Abe K, et al., The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. EMBO J. 2015 Jun 3;34(11):1523-37

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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