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Sord Gene Detail
Summary
  • Symbol
    Sord
  • Name
    sorbitol dehydrogenase
  • Synonyms
    Sdh1, Sdh-1, Sodh-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98266
    NCBI Gene: 20322
  • Gene Overview
    MyGene.info: SORD
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122234839-122265337 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.59 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98266
 protein coding gene Chr2:122234749-122265340 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026409
 protein coding gene Chr2:125224668-125257317 (+)
A/J MGP_AJ_G0026371
 protein coding gene Chr2:120103246-120136221 (+)
AKR/J MGP_AKRJ_G0026348
 protein coding gene Chr2:123473093-123505421 (+)
BALB/cJ MGP_BALBcJ_G0026383
 protein coding gene Chr2:120338358-120369122 (+)
C3H/HeJ MGP_C3HHeJ_G0026128
 protein coding gene Chr2:123959074-123990827 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026830
 protein coding gene Chr2:129289554-129329007 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024209
 protein coding gene Chr2:115080351-115112037 (+)
CAST/EiJ MGP_CASTEiJ_G0025590
 protein coding gene Chr2:124296820-124328410 (+)
CBA/J MGP_CBAJ_G0026107
 protein coding gene Chr2:133836579-133869510 (+)
DBA/2J MGP_DBA2J_G0026244
 protein coding gene Chr2:119507766-119538240 (+)
FVB/NJ MGP_FVBNJ_G0026206
 protein coding gene Chr2:118294277-118326627 (+)
LP/J MGP_LPJ_G0026346
 protein coding gene Chr2:125479513-125512540 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026226
 protein coding gene Chr2:138054654-138089597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026885
 protein coding gene Chr2:123587705-123625267 (+)
PWK/PhJ MGP_PWKPhJ_G0025326
 protein coding gene Chr2:119118477-119149721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025126
 protein coding gene Chr2:122731149-122766252 (+)
WSB/EiJ MGP_WSBEiJ_G0025662
 protein coding gene Chr2:124444287-124476751 (+)



Homology
more
  • Human Ortholog
    SORD, sorbitol dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SORD, sorbitol dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-95n, SORD1
  • Links
    NCBI Gene ID: 6652
    neXtProt AC: NX_Q00796
    UniProt: Q00796

  • Chr Location
    15q21.1; chr15:45023104-45075089 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Sord mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a functional null allele found in strain C57BL/LiA exhibit no obvious abnormalities in the kidney or other physiological systems. An additional isoelectric focusing variant is found in Peru stocks and has about 25% of the activity of that in most inbred strains.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    270
  • Tissues
    270
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20322 NCBI Gene Model | MGI Sequence Detail 30499 C57BL/6J ±  kb
    transcript NM_146126 RefSeq | MGI Sequence Detail 2259 C57BL/6  
    polypeptide Q64442 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14340, MGD-MRK-14341, MGD-MRK-35108
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:222615 Abe K, et al., The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. EMBO J. 2015 Jun 3;34(11):1523-37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/06/2018
    MGI 6.13     		The Jackson Laboratory