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Ccl4 Gene Detail
Summary
  • Symbol
    Ccl4
  • Name
    chemokine (C-C motif) ligand 4
  • Synonyms
    Act-2, AT744.1, Mip1b, MIP-1B, MIP-1 beta, Scya4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98261
    NCBI Gene: 20303
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83553410-83555509 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.09 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98261
protein coding gene Chr11:83553410-83555509 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018857
protein coding gene Chr11:85026588-85028696 (+)
A/J MGP_AJ_G0018824
protein coding gene Chr11:81775110-81777218 (+)
AKR/J MGP_AKRJ_G0018794
protein coding gene Chr11:84213385-84215490 (+)
BALB/cJ MGP_BALBcJ_G0018797
protein coding gene Chr11:82192028-82194127 (+)
C3H/HeJ MGP_C3HHeJ_G0018611
protein coding gene Chr11:84274833-84276941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019249
protein coding gene Chr11:87613288-87615387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016882
protein coding gene Chr11:78890216-78892330 (+)
CAST/EiJ MGP_CASTEiJ_G0018166
protein coding gene Chr11:84852680-84854767 (+)
CBA/J MGP_CBAJ_G0018582
protein coding gene Chr11:91382790-91384898 (+)
DBA/2J MGP_DBA2J_G0018690
protein coding gene Chr11:81373556-81375661 (+)
FVB/NJ MGP_FVBNJ_G0018679
protein coding gene Chr11:80860158-80862257 (+)
LP/J MGP_LPJ_G0018760
protein coding gene Chr11:85568196-85570304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018706
protein coding gene Chr11:91546731-91548830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019289
protein coding gene Chr11:84493164-84495263 (+)
PWK/PhJ MGP_PWKPhJ_G0017935
protein coding gene Chr11:82133009-82135117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017727
protein coding gene Chr11:84017327-84021155 (+)
WSB/EiJ MGP_WSBEiJ_G0018217
protein coding gene Chr11:84345269-84347368 (+)



Homology
more
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Synonyms
    ACT2, AT744.1, G-26, HC21, LAG1, LAG-1, MIP1B, MIP1B1, MIP-1-beta, SCYA2, SCYA4
  • Links
    NCBI Gene ID: 6351
    neXtProt AC: NX_P13236
    UniProt: P13236

  • Chr Location
    17q12; chr17:36103827-36105621 (+)  GRCh38.p7

  • Human Ortholog
    CCL4L2, C-C motif chemokine ligand 4 like 2
  • Synonyms
    AT744.2, CCL4L, SCYA4L, SCYQ4L2
  • Links
    NCBI Gene ID: 9560
    neXtProt AC: NX_Q8NHW4

  • Chr Location
    17q12; chr17:36211063-36212878 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20303 NCBI Gene Model | MGI Sequence Detail 2100 C57BL/6J ±  kb
transcript NM_013652 RefSeq | MGI Sequence Detail 674 C57BL/6  
polypeptide P14097 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 4
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12242, MGD-MRK-14335
References
more
  • Summaries
    All 84
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:305421 Rosin JM, et al., A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Dev Cell. 2021 May 3;56(9):1326-1345.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/13/2021
MGI 6.17
The Jackson Laboratory