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Ccl4 Gene Detail
Summary
  • Symbol
    Ccl4
  • Name
    chemokine (C-C motif) ligand 4
  • Synonyms
    Act-2, AT744.1, Mip1b, MIP-1B, MIP-1 beta, Scya4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98261
    NCBI Gene: 20303
  • Gene Overview
    MyGene.info: CCL4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83662584-83664683 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.09 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98261
protein coding gene Chr11:83648624-83664683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018857
protein coding gene Chr11:85026588-85028696 (+)
A/J MGP_AJ_G0018824
protein coding gene Chr11:81775110-81777218 (+)
AKR/J MGP_AKRJ_G0018794
protein coding gene Chr11:84213385-84215490 (+)
BALB/cJ MGP_BALBcJ_G0018797
protein coding gene Chr11:82192028-82194127 (+)
C3H/HeJ MGP_C3HHeJ_G0018611
protein coding gene Chr11:84274833-84276941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019249
protein coding gene Chr11:87613288-87615387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016882
protein coding gene Chr11:78890216-78892330 (+)
CAST/EiJ MGP_CASTEiJ_G0018166
protein coding gene Chr11:84852680-84854767 (+)
CBA/J MGP_CBAJ_G0018582
protein coding gene Chr11:91382790-91384898 (+)
DBA/2J MGP_DBA2J_G0018690
protein coding gene Chr11:81373556-81375661 (+)
FVB/NJ MGP_FVBNJ_G0018679
protein coding gene Chr11:80860158-80862257 (+)
LP/J MGP_LPJ_G0018760
protein coding gene Chr11:85568196-85570304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018706
protein coding gene Chr11:91546731-91548830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019289
protein coding gene Chr11:84493164-84495263 (+)
PWK/PhJ MGP_PWKPhJ_G0017935
protein coding gene Chr11:82133009-82135117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017727
protein coding gene Chr11:84017327-84021155 (+)
WSB/EiJ MGP_WSBEiJ_G0018217
protein coding gene Chr11:84345269-84347368 (+)



Homology
more
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACT2, AT744.1, G-26, HC21, LAG1, LAG-1, MIP1B, MIP1B1, MIP-1-beta, SCYA2, SCYA4
  • Links
    NCBI Gene ID: 6351
    neXtProt AC: NX_P13236
    UniProt: P13236

  • Chr Location
    17q12; chr17:36103827-36105621 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018930 Ensembl Gene Model | MGI Sequence Detail 2100 C57BL/6J ±  kb
transcript ENSMUST00000019074 Ensembl | MGI Sequence Detail 660 Not Applicable  
polypeptide ENSMUSP00000019074 Ensembl | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 4
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12242, MGD-MRK-14335
References
more
  • Summaries
    All 82
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:272342 Hammond TR, et al., Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2019 Jan 15;50(1):253-271.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory