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Ccl4 Gene Detail
Summary
  • Symbol
    Ccl4
  • Name
    C-C motif chemokine ligand 4
  • Synonyms
    Act-2, AT744.1, Mip1b, MIP-1B, MIP-1 beta, Scya4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98261
    NCBI Gene: 20303
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83553410-83555509 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.09 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98261
protein coding gene Chr11:83553410-83555509 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018857
protein coding gene Chr11:85026588-85028696 (+)
A/J MGP_AJ_G0018824
protein coding gene Chr11:81775110-81777218 (+)
AKR/J MGP_AKRJ_G0018794
protein coding gene Chr11:84213385-84215490 (+)
BALB/cJ MGP_BALBcJ_G0018797
protein coding gene Chr11:82192028-82194127 (+)
C3H/HeJ MGP_C3HHeJ_G0018611
protein coding gene Chr11:84274833-84276941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019249
protein coding gene Chr11:87613288-87615387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016882
protein coding gene Chr11:78890216-78892330 (+)
CAST/EiJ MGP_CASTEiJ_G0018166
protein coding gene Chr11:84852680-84854767 (+)
CBA/J MGP_CBAJ_G0018582
protein coding gene Chr11:91382790-91384898 (+)
DBA/2J MGP_DBA2J_G0018690
protein coding gene Chr11:81373556-81375661 (+)
FVB/NJ MGP_FVBNJ_G0018679
protein coding gene Chr11:80860158-80862257 (+)
LP/J MGP_LPJ_G0018760
protein coding gene Chr11:85568196-85570304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018706
protein coding gene Chr11:91546731-91548830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019289
protein coding gene Chr11:84493164-84495263 (+)
PWK/PhJ MGP_PWKPhJ_G0017935
protein coding gene Chr11:82133009-82135117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017727
protein coding gene Chr11:84017327-84021155 (+)
WSB/EiJ MGP_WSBEiJ_G0018217
protein coding gene Chr11:84345269-84347368 (+)



Homology
more
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Synonyms
    ACT2, AT744.1, G-26, HC21, LAG1, LAG-1, MIP1B, MIP1B1, MIP-1-beta, SCYA2, SCYA4
  • Links
    NCBI Gene ID: 6351
    neXtProt AC: NX_P13236
    UniProt: P13236

  • Chr Location
    17q12; chr17:36103827-36105621 (+)  GRCh38

  • Human Ortholog
    CCL4L1, C-C motif chemokine ligand 4 like 1
  • Synonyms
    AT744.2, CCL4L, LAG1, LAG-1, MIP-1-beta, SCYA4L, SCYA4L1, SCYA4L2
  • Links
    NCBI Gene ID: 388372
    neXtProt AC: NX_P13236, NX_Q8NHW4
    UniProt: Q8NHW4

  • Chr Location
    17q12; chr17:36210924-36212878 (+)  GRCh38

  • Human Ortholog
    CCL4L2, C-C motif chemokine ligand 4 like 2
  • Synonyms
    AT744.2, CCL4L, SCYA4L, SCYQ4L2
  • Links
    NCBI Gene ID: 9560
    neXtProt AC: NX_Q8NHW4

  • Chr Location
    17q12; chr17:36210924-36212878 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CCL4,CCL4L2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20303 NCBI Gene Model | MGI Sequence Detail 2100 C57BL/6J ±  kb
transcript NM_013652 RefSeq | MGI Sequence Detail 674 ZRU/MplStud  
polypeptide P14097 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 4
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12242, MGD-MRK-14335
References
more
  • Summaries
    All 92
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:342656 Schorn F, et al., cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. 2023 Nov 15;42(22):e113614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory