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Ccl3
Gene Detail
Symbol

Name
ID
Ccl3
chemokine (C-C motif) ligand 3
MGI:98260
STS
Synonyms
CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, Mip1a, MIP1-(a), MIP-1alpha, MIP-1 alpha, MIP1-alpha, Scya3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr11:83647844-83649355 bp, - strand
From VEGA annotation of GRCm38

  1512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CCL3, CCL3L3
Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl3

Human
homologs
CCL3, chemokine (C-C motif) ligand 3
Orthology source: HGNC

IDs:
NCBI Gene ID: 6348
neXtProt AC: NX_P10147

Human Synonyms: G0S19-1, LD78ALPHA, MIP1A, MIP-1-alpha, SCYA3

Human Chr (Location): 17q12; chr17:36088256-36090160 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CCL3

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Ccl3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene exhibit resistance to Coxsackie virus-induced myocarditis and reduced pneumonitis following infection with influenza virus.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Ccl3 interacts with 43 markers (Mir16-2, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process astrocyte cell migration, cell chemotaxis, ...
Component cell, cytosol, ...
Function chemokine activity, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (52)    Tissues (12)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RT-PCR 40
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(3) cDNA(42) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000991 (Evidence)
Ensembl Gene Model ENSMUSG00000000982 (Evidence)
Entrez Gene 20302 (Evidence)
UniGene 1282
DFCI TC1578043
DoTS DT.534176, DT.94283823
NIA Mouse Gene Index U033198
Consensus CDS Project CCDS36255.1
International Mouse Phenotyping Consortium Status Ccl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000991 VEGA Gene Model | MGI Sequence Detail 1512 C57BL/6J ±  kb
transcript OTTMUST00000001950 VEGA | MGI Sequence Detail 766 Not Applicable 
polypeptide OTTMUSP00000000942 VEGA | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002123 C-C motif chemokine 3
References
(Earliest) J:9234 Davatelis G, et al., Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties [published erratum appears in J Exp Med 1989 Dec 1;170(6):2189]. J Exp Med. 1988 Jun 1;167(6):1939-44
(Latest) J:216208 Cudaback E, et al., APOE genotype-dependent modulation of astrocyte chemokine CCL3 production. Glia. 2015 Jan;63(1):51-65
All references(163)
Other
accession IDs
MGD-MRK-12241, MGD-MRK-14334, MGI:2144123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory