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Ccl3
Gene Detail
 Symbol
Name
ID
Ccl3
chemokine (C-C motif) ligand 3
MGI:98260
STS D11Mit35
Synonyms CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, Mip1a, MIP1-(a), MIP-1alpha, MIP-1 alpha, MIP1-alpha, Scya3
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr11:83647844-83649355 bp, - strand
From VEGA annotation of GRCm38

  1512 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: small inducible chemokine, C/CC types
Gene Tree: Ccl3

Human
homologs
Human Homolog CCL3L3, chemokine (C-C motif) ligand 3-like 3
NCBI Gene ID 414062
neXtProt AC  NX_P16619
Human Synonyms  464.2, D17S1718, G0S19-2, LD78, LD78BETA, SCYA3L, SCYA3L1
Human Chr (Location)  17q21.1; chr17:36194869-36196748 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene exhibit resistance to Coxsackie virus-induced myocarditis and reduced pneumonitis following infection with influenza virus.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Ccl3 interacts with 43 markers (Mir16-2, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process astrocyte cell migration, cell chemotaxis, ...
Component cell, cytosol, ...
Function chemokine activity, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (52)    Tissues (12)    Images (4)
Theiler Stages: 28
Assay TypeResults
Immunohistochemistry 12
RT-PCR 40
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(3) cDNA(42) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000991 (Evidence)
Ensembl Gene ModelENSMUSG00000000982 (Evidence)
Entrez Gene20302 (Evidence)
UniGene1282
DFCITC1578043
DoTSDT.534176, DT.94283823
NIA Mouse Gene IndexU033198
Consensus CDS ProjectCCDS36255.1
International Mouse Knockout Project StatusCcl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000991 VEGA Gene Model | MGI Sequence Detail 1512 C57BL/6J ±  kb
transcript OTTMUST00000001950 VEGA | MGI Sequence Detail 766 Not Applicable 
polypeptide OTTMUSP00000000942 VEGA | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000827 CC chemokine, conserved site
InterPro IPR001811 Chemokine interleukin-8-like domain
Protein Ontology PR:000002123 C-C motif chemokine 3
References (Earliest) J:9234 Davatelis G, et al., Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties [published erratum appears in J Exp Med 1989 Dec 1;170(6):2189]. J Exp Med. 1988 Jun 1;167(6):1939-44
(Latest) J:210001 Kohno H, et al., CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014 Apr 15;192(8):3816-27
All references(164)
Other
accession IDs
MGD-MRK-12241, MGD-MRK-14334, MGI:2144123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory