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Scp2 Gene Detail
Summary
  • Symbol
    Scp2
  • Name
    sterol carrier protein 2, liver
  • Synonyms
    nonspecific lipid transfer protein, ns-LTP, NSL-TP, SCP-2, SCPx
  • Feature Type
    protein coding gene
  • IDs
    MGI:98254
    NCBI Gene: 20280
  • Gene Overview
    MyGene.info: SCP2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:108043839-108144998 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101160 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.20 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    SCP2, sterol carrier protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCP2, sterol carrier protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NLTP, NSL-TP, SCP-2, SCP-CHI, SCPX, SCP-X
  • Links
    NCBI Gene ID: 6342
    neXtProt AC: NX_P22307
    UniProt: P22307

  • Chr Location
    1p32.3; chr1:52927229-53051617 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37717
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SCP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene exhibit altered lipid levels and both males and females are sensitive to phytol-rich diets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009429 VEGA Gene Model | MGI Sequence Detail 101160 C57BL/6J ±  kb
    transcript OTTMUST00000021471 VEGA | MGI Sequence Detail 2640 Not Applicable  
    polypeptide OTTMUSP00000009814 VEGA | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      683 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 391
      Genomic 4
      cDNA 383
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14327, MGI:2140147, MGI:2140148, MGI:2140647, MGI:2140673
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:11174 Moncecchi D, et al., cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2. J Biol Chem. 1991 May 25;266(15):9885-92
    • Latest
      J:259684 Milligan S, et al., Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice. Biochim Biophys Acta. 2018 Mar;1863(3):323-338

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory