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Scp2
Gene Detail
 Symbol
Name
ID
Scp2
sterol carrier protein 2, liver
MGI:98254
Synonyms nonspecific lipid transfer protein, ns-LTP, NSL-TP, SCP-2, SCPx
Feature Type protein coding gene
Genetic Map
Chromosome 4
50.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:108043839-108144998 bp, - strand
From VEGA annotation of GRCm38

  101160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Scp2

Human
homologs
Human Homolog SCP2, sterol carrier protein 2
NCBI Gene ID 6342
neXtProt AC  NX_P22307
Human Synonyms  NLTP, NSL-TP, SCP-2, SCP-CHI, SCPX, SCP-X
Human Chr (Location)  1p32; chr1:52927229-53051617 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCP2
Alleles
and
phenotypes
All alleles(30) : Targeted(5) Gene trapped(25)
 
Mice homozygous for disruptions of this gene exhibit altered lipid levels and both males and females are sensitive to phytol-rich diets.
 
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process acyl-CoA metabolic process, inositol trisphosphate biosynthetic process, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function catalytic activity, cholesterol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (122)    Tissues (113)    Images (1)
Theiler Stages: 15, 19, 22, 24, 26, 28
Assay TypeResults
RNA in situ 107
Northern blot 15
cDNA source data(381)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(387) Genomic(4) cDNA(383)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009429 (Evidence)
Ensembl Gene ModelENSMUSG00000028603 (Evidence)
Entrez Gene20280 (Evidence)
UniGene379011
DFCITC1574006
DoTSDT.101408495, DT.496667, DT.94375390, DT.97368901
NIA Mouse Gene IndexU025351, U031472
EC2.3.1.176
Consensus CDS ProjectCCDS18446.1
International Mouse Knockout Project StatusScp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009429 VEGA Gene Model | MGI Sequence Detail 101160 C57BL/6J ±  kb
transcript OTTMUST00000021471 VEGA | MGI Sequence Detail 2640 Not Applicable 
polypeptide OTTMUSP00000009814 VEGA | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(699 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003033 SCP2 sterol-binding domain
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000014534 non-specific lipid-transfer protein
References (Earliest) J:11174 Moncecchi D, et al., cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2. J Biol Chem. 1991 May 25;266(15):9885-92
(Latest) J:185389 Storey SM, et al., Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G824-39
All references(68)
Other
accession IDs
MGD-MRK-14327, MGI:2140147, MGI:2140148, MGI:2140647, MGI:2140673

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory