Scp2
Gene Detail

Symbol Name ID

Scp2 sterol carrier protein 2, liver MGI:98254

Synonyms

nonspecific lipid transfer protein, ns-LTP, NSL-TP, SCP-2, SCPx

Feature Type

protein coding gene

Genetic Map

Chromosome 4

50.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:108043839-108144998 bp, - strand From VEGA annotation of GRCm38   101160 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Scp2

Human homologs

Human Homolog		SCP2, sterol carrier protein 2
NCBI Gene ID		6342
neXtProt AC		NX_P22307
Human Synonyms		NLTP, NSL-TP, SCP-2, SCP-CHI, SCPX, SCP-X
Human Chr (Location)		1p32; chr1:53392901-53517289 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SCP2

Alleles and phenotypes

All alleles(30) : Targeted(5) Gene trapped(25)
 

Mice homozygous for disruptions of this gene exhibit altered lipid levels and both males and females are sensitive to phytol-rich diets.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	acyl-CoA metabolic process, inositol trisphosphate biosynthetic process, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	catalytic activity, cholesterol binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (122)    Tissues (113)    Images (1)
Theiler Stages: 15, 19, 22, 24, 26, 28

Assay Type	Results
RNA in situ	107
Northern blot	15

cDNA source data(380)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(386) Genomic(4) cDNA(382)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000009429 (Evidence)
Ensembl Gene Model	ENSMUSG00000028603 (Evidence)
Entrez Gene	20280 (Evidence)
UniGene	379011
DFCI	TC1574006
DoTS	DT.101408495, DT.496667, DT.94375390, DT.97368901
NIA Mouse Gene Index	U025351, U031472
EC	2.3.1.176
Consensus CDS Project	CCDS18446.1
International Mouse Knockout Project Status	Scp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009429	VEGA Gene Model | MGI Sequence Detail	101160	C57BL/6J
transcript	OTTMUST00000021471	VEGA | MGI Sequence Detail	2640	Not Applicable
polypeptide	OTTMUSP00000009814	VEGA | MGI Sequence Detail	547	Not Applicable

All sequences(64) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(358 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003033	SCP2 sterol-binding domain
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000014534	non-specific lipid-transfer protein

References

(Earliest) J:11174 Moncecchi D, et al., cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2. J Biol Chem. 1991 May 25;266(15):9885-92
(Latest) J:185389 Storey SM, et al., Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G824-39
All references(67)

Other accession IDs

MGD-MRK-14327, MGI:2140147, MGI:2140148, MGI:2140647, MGI:2140673