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Scp2
Gene Detail
Symbol

Name
ID
Scp2
sterol carrier protein 2, liver
MGI:98254
Synonyms
nonspecific lipid transfer protein, ns-LTP, NSL-TP, SCP-2, SCPx
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:108043839-108144998 bp, - strand
From VEGA annotation of GRCm38

  101160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37717  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SCP2
Gene Tree: Scp2

Human
homologs
SCP2, sterol carrier protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6342
neXtProt AC: NX_P22307

Human Synonyms: NLTP, NSL-TP, SCP-2, SCP-CHI, SCPX, SCP-X

Human Chr (Location): 1p32; chr1:52927229-53051617 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SCP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(25) Targeted(6)
Genomic Mutations involving Scp2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene exhibit altered lipid levels and both males and females are sensitive to phytol-rich diets.
 
Interactions
Scp2 interacts with 115 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process acyl-CoA metabolic process, aging, ...
Component cytoplasm, cytosol, ...
Function acetyl-CoA C-acyltransferase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (128)    Tissues (118)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
Northern blot 15
RT-PCR 6
cDNA source data(381)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase scp2 ; ZFIN scp2a    NEW 
Molecular
reagents
All nucleic(391) Genomic(4) cDNA(383) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000009429 (Evidence)
Ensembl Gene Model ENSMUSG00000028603 (Evidence)
Entrez Gene 20280 (Evidence)
UniGene 379011
DFCI TC1574006
DoTS DT.101408495, DT.496667, DT.94375390, DT.97368901
NIA Mouse Gene Index U025351, U031472
EC 2.3.1.176
Consensus CDS Project CCDS18446.1
International Mouse Phenotyping Consortium Status Scp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009429 VEGA Gene Model | MGI Sequence Detail 101160 C57BL/6J ±  kb
transcript OTTMUST00000021471 VEGA | MGI Sequence Detail 2640 Not Applicable 
polypeptide OTTMUSP00000009814 VEGA | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(699 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003033 SCP2 sterol-binding domain
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000014534 non-specific lipid-transfer protein
References
(Earliest) J:11174 Moncecchi D, et al., cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2. J Biol Chem. 1991 May 25;266(15):9885-92
(Latest) J:185389 Storey SM, et al., Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G824-39
All references(66)
Other
accession IDs
MGD-MRK-14327, MGI:2140147, MGI:2140148, MGI:2140647, MGI:2140673

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory