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Scn1b Gene Detail
Summary
  • Symbol
    Scn1b
  • Name
    sodium channel, voltage-gated, type I, beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:98247
    NCBI Gene: 20266
  • Gene Overview
    MyGene.info: SCN1B
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:31116524-31127003 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98247
protein coding gene Chr7:31116524-31127035 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032062
protein coding gene Chr7:30180104-30191750 (-)
A/J MGP_AJ_G0032039
protein coding gene Chr7:29366533-29376818 (-)
AKR/J MGP_AKRJ_G0031972
protein coding gene Chr7:30104655-30114949 (-)
BALB/cJ MGP_BALBcJ_G0032046
protein coding gene Chr7:29541282-29552059 (-)
C3H/HeJ MGP_C3HHeJ_G0031763
protein coding gene Chr7:30567933-30578372 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032512
protein coding gene Chr7:31186797-31197533 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029562
protein coding gene Chr7:30319700-30329505 (-)
CAST/EiJ MGP_CASTEiJ_G0031099
protein coding gene Chr7:23822337-23835202 (-)
CBA/J MGP_CBAJ_G0031731
protein coding gene Chr7:32644656-32656120 (-)
DBA/2J MGP_DBA2J_G0031883
protein coding gene Chr7:29080519-29090847 (-)
FVB/NJ MGP_FVBNJ_G0031839
protein coding gene Chr7:29198927-29209316 (-)
LP/J MGP_LPJ_G0031964
protein coding gene Chr7:30519038-30529384 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031876
protein coding gene Chr7:31868696-31881267 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032538
protein coding gene Chr7:29615274-29626054 (-)
PWK/PhJ MGP_PWKPhJ_G0030821
protein coding gene Chr7:24122054-24132447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030658
protein coding gene Chr7:20607139-20618231 (-)
WSB/EiJ MGP_WSBEiJ_G0031209
protein coding gene Chr7:30022653-30034129 (-)



Homology
more
  • Human Ortholog
    SCN1B, sodium voltage-gated channel beta subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCN1B, sodium voltage-gated channel beta subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATFB13, BRGDA5, EIEE52, GEFSP1
  • Links
    NCBI Gene ID: 6324
    neXtProt AC: NX_Q07699
    UniProt: Q07699

  • Chr Location
    19q13.11; chr19:35030688-35040449 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Scn1b mouse models; 3 with human SCN1B associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in defects in neuronal excitability, and nodal architecture. Homozygous null mice are growth retarded, exhibit spontaneous generalized seizuress, and die prior to weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019194 Ensembl Gene Model | MGI Sequence Detail 10480 C57BL/6J ±  kb
    transcript ENSMUST00000211945 Ensembl | MGI Sequence Detail 1501 Not Applicable  
    polypeptide ENSMUSP00000148295 Ensembl | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 26
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14320
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:15251 Tong J, et al., A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Biochem Biophys Res Commun. 1993 Sep 15;195(2):679-85
    • Latest
      J:264801 Chen C, et al., Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Ann Clin Transl Neurol. 2018 Aug;5(8):982-987

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory