Scn1b
Gene Detail

Symbol Name ID

Scn1b sodium channel, voltage-gated, type I, beta MGI:98247

Feature Type

protein coding gene

Genetic Map

Chromosome 7

19.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:31116525-31126945 bp, - strand From Ensembl annotation of GRCm38   10421 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn1b

Human homologs

Human Homolog		SCN1B, sodium channel, voltage-gated, type I, beta subunit
NCBI Gene ID		6324
neXtProt AC		NX_Q07699
Human Synonyms		GEFSP1
Human Chr (Location)		19q13.1; chr19:35521592-35531353 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SCN1B

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous inactivation of this locus results in defects in neuronal excitability, and nodal architecture. Homozygous null mice are growth retarded, exhibit spontaneous generalized seizuress, and die prior to weaning.

 
Human Diseases Modeled Using Mouse Scn1b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	axon guidance, cardiac conduction, ...
Component	integral to membrane, intercalated disc, ...
Function	ion channel activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (59)    Tissues (30)   
Theiler Stages: 15, 17, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	38
RT-PCR	21

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(2) cDNA(25) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000019194 (Evidence)
Entrez Gene	20266 (Evidence)
UniGene	1418
DFCI	TC1583203, TC1589513, TC1596710
DoTS	DT.488257, DT.94179895
NIA Mouse Gene Index	U028414
Consensus CDS Project	CCDS21126.1
International Mouse Knockout Project Status	Scn1b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000019194	Ensembl Gene Model | MGI Sequence Detail	10421	C57BL/6J
transcript	ENSMUST00000098548	Ensembl | MGI Sequence Detail	1514	Not Applicable
polypeptide	ENSMUSP00000096148	Ensembl | MGI Sequence Detail	218	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013151	Immunoglobulin
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000014522	sodium channel subunit beta-1

References

(Earliest) J:15251 Tong J, et al., A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Biochem Biophys Res Commun. 1993 Sep 15;195(2):679-85
(Latest) J:191240 Nguyen HM, et al., Modulation of voltage-gated K+ channels by the sodium channel beta1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18577-82
All references(49)

Other accession IDs

MGD-MRK-14320