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Scn1b
Gene Detail
 Symbol
Name
ID
Scn1b
sodium channel, voltage-gated, type I, beta
MGI:98247
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:31116524-31126945 bp, - strand
From VEGA annotation of GRCm38

  10422 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn1b

Human
homologs
Human Homolog SCN1B, sodium channel, voltage-gated, type I, beta subunit
NCBI Gene ID 6324
neXtProt AC  NX_Q07699
Human Synonyms  ATFB13, BRGDA5, GEFSP1
Human Chr (Location)  19q13.1; chr19:35030688-35040449 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human SCN1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous inactivation of this locus results in defects in neuronal excitability, and nodal architecture. Homozygous null mice are growth retarded, exhibit spontaneous generalized seizuress, and die prior to weaning.
 
Human Diseases Modeled Using Mouse Scn1b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Scn1b interacts with 90 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process axon guidance, cardiac conduction, ...
Component integral component of membrane, intercalated disc, ...
Function protein binding, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (59)    Tissues (32)   
Theiler Stages: 15, 17, 19, 20, 21, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 38
RT-PCR 21
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(25) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000045672 (Evidence)
Ensembl Gene ModelENSMUSG00000019194 (Evidence)
Entrez Gene20266 (Evidence)
UniGene1418
DFCITC1583203, TC1589513, TC1596710
DoTSDT.488257, DT.94179895
NIA Mouse Gene IndexU028414
Consensus CDS ProjectCCDS21126.1
International Mouse Knockout Project StatusScn1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045672 VEGA Gene Model | MGI Sequence Detail 10422 C57BL/6J ±  kb
transcript OTTMUST00000119567 VEGA | MGI Sequence Detail 1515 Not Applicable 
polypeptide OTTMUSP00000066474 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR027098 Sodium channel subunit beta-1/beta-3
Protein Ontology PR:000014522 sodium channel subunit beta-1
References (Earliest) J:15251 Tong J, et al., A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Biochem Biophys Res Commun. 1993 Sep 15;195(2):679-85
(Latest) J:193628 Brackenbury WJ, et al., Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1089-94
All references(52)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory