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Scn1b
Gene Detail
Symbol

Name
ID
Scn1b
sodium channel, voltage-gated, type I, beta
MGI:98247
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:31116524-31127026 bp, - strand
From VEGA annotation of GRCm38

  10503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SCN1B
Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn1b

Human
homologs
SCN1B, sodium channel, voltage gated, type I beta subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6324
neXtProt AC: NX_Q07699

Human Synonyms: ATFB13, BRGDA5, GEFSP1

Human Chr (Location): 19q13.1; chr19:35030688-35040449 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SCN1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous inactivation of this locus results in defects in neuronal excitability, and nodal architecture. Homozygous null mice are growth retarded, exhibit spontaneous generalized seizuress, and die prior to weaning.
 
Human Diseases Modeled in Mice Using Scn1b (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Scn1b interacts with 89 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process axon guidance, cardiac conduction, ...
Component integral component of membrane, intercalated disc, ...
Function protein binding, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (59)    Tissues (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RT-PCR 21
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN scn1ba, scn1bb    NEW 
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(25) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000045672 (Evidence)
Ensembl Gene Model ENSMUSG00000019194 (Evidence)
Entrez Gene 20266 (Evidence)
UniGene 1418
DFCI TC1583203, TC1589513, TC1596710
DoTS DT.488257, DT.94179895
NIA Mouse Gene Index U028414
Consensus CDS Project CCDS21126.1
International Mouse Phenotyping Consortium Status Scn1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045672 VEGA Gene Model | MGI Sequence Detail 10503 C57BL/6J ±  kb
transcript OTTMUST00000119568 VEGA | MGI Sequence Detail 1501 Not Applicable 
polypeptide OTTMUSP00000066475 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR027098 Sodium channel subunit beta-1/beta-3
Protein Ontology PR:000014522 sodium channel subunit beta-1
References
(Earliest) J:15251 Tong J, et al., A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Biochem Biophys Res Commun. 1993 Sep 15;195(2):679-85
(Latest) J:211437 de la Rosa AJ, et al., Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Cardiovasc Res. 2013 Jun 1;98(3):504-14
All references(51)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory