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Scd2
Gene Detail
Symbol

Name
ID
Scd2
stearoyl-Coenzyme A desaturase 2
MGI:98240
Synonyms
Scd-2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:44293676-44306864 bp, + strand
From NCBI annotation of GRCm38

  13189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136612  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: acyl-CoA desaturase
Gene Tree: Scd2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with variable penetrance depending on stain background, impaired skin barrier function, abnormal epidermal morphology, and abnormal lipid homeostasis in the skin and liver.
 
Phenotype Images(1)
Interactions
Scd2 interacts with 338 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function iron ion binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (115)    Tissues (113)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025203 (Evidence)
Entrez Gene20250 (Evidence)
EC1.14.19.1
Consensus CDS ProjectCCDS29848.1
International Mouse Knockout Project StatusScd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20250 NCBI Gene Model | MGI Sequence Detail 13189 C57BL/6J ±  kb
transcript NM_009128 RefSeq | MGI Sequence Detail 5453 C57BL/6 
polypeptide P13011 UniProt | EBI | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005804 Fatty acid desaturase, type 1
InterPro IPR015876 Fatty acid desaturase, type 1, core
InterPro IPR001522 Fatty acid desaturase, type 1, C-terminal
Protein Ontology PR:000015922 acyl-CoA desaturase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:9973 Kaestner KH, et al., Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1989 Sep 5;264(25):14755-61
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(52)
Other
accession IDs
MGD-MRK-14306, MGD-MRK-14308, MGI:3584399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory