About   Help   FAQ
Scd2 Gene Detail
Summary
  • Symbol
    Scd2
  • Name
    stearoyl-Coenzyme A desaturase 2
  • Synonyms
    Scd-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98240
    NCBI Gene: 20250
  • Gene Overview
    MyGene.info: SCD
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:44293676-44306864 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13189 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 37.98 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
    Orthology source: HGNC
  • Synonyms
    FADS5, hSCD1, MSTP008, SCD1, SCDOS
  • Links
    NCBI Gene ID: 6319
    neXtProt AC: NX_O00767
    UniProt: O00767

  • Chr Location
    10q24.31; chr10:100347015-100364831 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with variable penetrance depending on stain background, impaired skin barrier function, abnormal epidermal morphology, and abnormal lipid homeostasis in the skin and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20250 NCBI Gene Model | MGI Sequence Detail 13189 C57BL/6J ±  kb
    transcript NM_009128 RefSeq | MGI Sequence Detail 5453 C57BL/6  
    polypeptide P13011 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      124 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 15
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14306, MGD-MRK-14308, MGI:3584399
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 14
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:9973 Kaestner KH, et al., Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1989 Sep 5;264(25):14755-61
    • Latest
      J:234197 Wong BH, et al., Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory