Scd1
Gene Detail

Symbol Name ID

Scd1 stearoyl-Coenzyme A desaturase 1 MGI:98239

Synonyms

SCD, Scd-1, stearoyl-CoA desaturase

Feature Type

protein coding gene

Genetic Map

Chromosome 19

37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr19:44394451-44407709 bp, - strand From Ensembl annotation of GRCm38   13259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: acyl-CoA desaturase
Gene Tree: Scd1

Human homologs

Human Homolog		SCD, stearoyl-CoA desaturase (delta-9-desaturase)
NCBI Gene ID		6319
neXtProt AC		NX_O00767, NX_Q9H354
Human Synonyms		FADS5, MSTP008, SCD1, SCDOS
Human Chr (Location)		10q24.31; chr10:100347015-100364831 (+)  GRCh38

Alleles and phenotypes

All alleles(14) : Chemically induced (ENU)(1) Gene trapped(7) Spontaneous(4) Targeted(2)
Incidental mutations (data from APF )
 

Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	brown fat cell differentiation, cholesterol esterification, ...
Component	endoplasmic reticulum, integral component of membrane, ...
Function	iron ion binding, oxidoreductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)

Data Summary: Results (136)    Tissues (102)    Images (38)
Theiler Stages: 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	118
Northern blot	9
RT-PCR	8

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(7) cDNA(34) Primer pair(4)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000037071 (Evidence)
Entrez Gene	20249 (Evidence)
NIA Mouse Gene Index	U039075
EC	1.14.19.1
Consensus CDS Project	CCDS29850.1
International Mouse Knockout Project Status	Scd1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000037071	Ensembl Gene Model | MGI Sequence Detail	13259	C57BL/6J
transcript	ENSMUST00000041331	Ensembl | MGI Sequence Detail	4836	Not Applicable
polypeptide	ENSMUSP00000036936	Ensembl | MGI Sequence Detail	355	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(4) : SNPs within 2kb(79 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR005804	Fatty acid desaturase, type 1
InterPro	IPR015876	Fatty acid desaturase, type 1, core
InterPro	IPR001522	Fatty acid desaturase, type 1, C-terminal
Protein Ontology	PR:000015921	acyl-CoA desaturase 1

References

(Earliest) J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
(Latest) J:209514 Sampath H, et al., Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014 Jan 31;289(5):2482-8
All references(160)

Other accession IDs

MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858