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Scd1
Gene Detail
 Symbol
Name
ID
Scd1
stearoyl-Coenzyme A desaturase 1
MGI:98239
Synonyms SCD, Scd-1, stearoyl-CoA desaturase
Feature Type protein coding gene
Genetic Map
Chromosome 19
37.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr19:44394451-44407709 bp, - strand
From Ensembl annotation of GRCm38

  13259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: acyl-CoA desaturase
Gene Tree: Scd1

Human
homologs
Human Homolog SCD, stearoyl-CoA desaturase (delta-9-desaturase)
NCBI Gene ID 6319
neXtProt AC  NX_O00767, NX_Q9H354
Human Synonyms  FADS5, MSTP008, SCD1, SCDOS
Human Chr (Location)  10q24.31; chr10:100347015-100364831 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(7) Spontaneous(4) Targeted(2)
Incidental mutations (data from APF )
 
Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females.
 
Phenotype Images(2)
Interactions
Scd1 interacts with 325 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process brown fat cell differentiation, cholesterol esterification, ...
Component endoplasmic reticulum, integral component of endoplasmic reticulum membrane, ...
Function iron ion binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (136)    Tissues (102)    Images (38)
Theiler Stages: 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 118
Northern blot 9
RT-PCR 8
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(7) cDNA(34) Primer pair(4)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000037071 (Evidence)
Entrez Gene20249 (Evidence)
NIA Mouse Gene IndexU039075
EC1.14.19.1
Consensus CDS ProjectCCDS29850.1
International Mouse Knockout Project StatusScd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037071 Ensembl Gene Model | MGI Sequence Detail 13259 C57BL/6J ±  kb
transcript ENSMUST00000041331 Ensembl | MGI Sequence Detail 4836 Not Applicable 
polypeptide ENSMUSP00000036936 Ensembl | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms RFLP(4) : SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005804 Fatty acid desaturase, type 1
InterPro IPR015876 Fatty acid desaturase, type 1, core
InterPro IPR001522 Fatty acid desaturase, type 1, C-terminal
Protein Ontology PR:000015921 acyl-CoA desaturase 1
References (Earliest) J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
(Latest) J:209514 Sampath H, et al., Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014 Jan 31;289(5):2482-8
All references(161)
Other
accession IDs
MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory