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Scd1 Gene Detail
Summary
  • Symbol
    Scd1
  • Name
    stearoyl-Coenzyme A desaturase 1
  • Synonyms
    SCD, Scd-1, stearoyl-CoA desaturase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98239
    NCBI Gene: 20249
  • Alliance
    gene page
  • Transcription Start Sites
    87 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44382889-44396148 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 37.98 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98239
 protein coding gene Chr19:44382889-44396318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025170
 protein coding gene Chr19:43875426-43890076 (-)
A/J MGP_AJ_G0025147
 protein coding gene Chr19:41775309-41788567 (-)
AKR/J MGP_AKRJ_G0025115
 protein coding gene Chr19:43118810-43133816 (-)
BALB/cJ MGP_BALBcJ_G0025141
 protein coding gene Chr19:41825984-41839242 (-)
C3H/HeJ MGP_C3HHeJ_G0024901
 protein coding gene Chr19:43277617-43290867 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025584
 protein coding gene Chr19:44956723-44969981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022998
 protein coding gene Chr19:41056735-41069912 (-)
CAST/EiJ MGP_CASTEiJ_G0024366
 protein coding gene Chr19:42982922-42997663 (-)
CBA/J MGP_CBAJ_G0024881
 protein coding gene Chr19:47220986-47234248 (-)
DBA/2J MGP_DBA2J_G0025013
 protein coding gene Chr19:41591584-41604985 (-)
FVB/NJ MGP_FVBNJ_G0024974
 protein coding gene Chr19:41365523-41378812 (-)
LP/J MGP_LPJ_G0025099
 protein coding gene Chr19:43818252-43832410 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025005
 protein coding gene Chr19:46666067-46679325 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025642
 protein coding gene Chr19:43185878-43200194 (-)
PWK/PhJ MGP_PWKPhJ_G0024115
 protein coding gene Chr19:41493577-41507584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023919
 protein coding gene Chr19:41902401-41916077 (-)
WSB/EiJ MGP_WSBEiJ_G0024436
 protein coding gene Chr19:43315376-43329083 (-)



Homology
more
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
  • Synonyms
    FADS5, hSCD1, MSTP008, SCD1, SCDOS
  • Links
    NCBI Gene ID: 6319
    neXtProt AC: NX_O00767
    UniProt: O00767

  • Chr Location
    10q24.31; chr10:100347015-100364831 (+)  GRCh38.p7
  • Human Ortholog
    SCD5, stearoyl-CoA desaturase 5
  • Synonyms
    ACOD4, DFNA79, FADS4, HSCD5, SCD2, SCD4
  • Links
    NCBI Gene ID: 79966
    neXtProt AC: NX_Q86SK9
    UniProt: Q86SK9

  • Chr Location
    4q21.22; chr4:82629537-82798857 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human SCD5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 8 alleles in 9 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    110
  • cDNA Data
    32
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20249 NCBI Gene Model | MGI Sequence Detail 13260 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 7
      cDNA 35
      Primer pair 8

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858
    References
    more
    • Summaries
      All 238
      Developmental Gene Expression 44
      Gene Ontology 18
      Phenotypes 96
    • Earliest
      J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
    • Latest
      J:319818 Abd Alla J, et al., Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation. Int J Mol Sci. 2021 Sep 13;22(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/10/2022
    MGI 6.19     		The Jackson Laboratory