Scd1 MGI Mouse Gene Detail - MGI:98239 - stearoyl-Coenzyme A desaturase 1

Scd1 Gene Detail

Symbol

Scd1
Name

stearoyl-Coenzyme A desaturase 1
Synonyms

SCD, Scd-1, stearoyl-CoA desaturase

Feature Type

protein coding gene
IDs

MGI:98239
NCBI Gene: 20249
Gene Overview

MyGene.info: SCD

Sequence Map

Chr19:44394451-44407709 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

13259 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 37.98 cM
Mapping Data

25 experiments

Human Ortholog

SCD, stearoyl-CoA desaturase

Vertebrate Orthologs

10

Human Ortholog

SCD, stearoyl-CoA desaturase
Orthology source: HomoloGene, HGNC
Synonyms

FADS5, hSCD1, MSTP008, SCD1, SCDOS
Links

HGNC:10571

NCBI Gene ID: 6319

neXtProt AC: NX_O00767, NX_Q9H354
Chr Location

10q24.31; chr10:100347015-100364831 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 74538
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SCD
Protein SuperFamily

acyl-CoA desaturase
Gene Tree

Scd1

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Phenotype Summary

91 phenotypes from 8 alleles in 9 genetic backgrounds
16 phenotypes from multigenic genotypes
2 images
73 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Gene trapped

7
Spontaneous

4
Targeted

2
Transgenic

2
Genomic Mutations

1 involving Scd1
Incidental Mutations

APF

Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females.

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All GO Annotations

46
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

138
Tissues

103
cDNA Data

31
Literature Summary

30

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase scd

ZFIN scd, scdb

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Scd1 interacts with 324 markers (Mir7-1, Mir7b, Mir9-1, ...) View All

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS29850.1

Ensembl

ENSMUSG00000037071 (Evidence)
NCBI Gene

20249

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037071	Ensembl Gene Model \| MGI Sequence Detail	13259	C57BL/6J	± kb
transcript	ENSMUST00000041331	Ensembl \| MGI Sequence Detail	4836	Not Applicable
polypeptide	ENSMUSP00000036936	Ensembl \| MGI Sequence Detail	355	Not Applicable

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SNPs within 2kb

79 from dbSNP Build 142

RFLP

4

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UniProt

3 Sequences
Protein Ontology

PR:000015921 acyl-CoA desaturase 1
PDB

4YMK
EC

1.14.19.1
InterPro Domains

IPR015876 Acyl-CoA desaturase

IPR005804 Fatty acid desaturase domain

IPR001522 Fatty acid desaturase type 1, conserved site

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All nucleic 46

Genomic 7

cDNA 34

Primer pair 5

Microarray probesets 9

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MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858

Summaries

All 169

Developmental Gene Expression 30

Gene Ontology 14

Phenotypes 73
Earliest

J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
Latest

J:233745 Ferrell JM, et al., Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 Jul;57(7):1144-54

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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