About   Help   FAQ
Scd1 Gene Detail
Summary
  • Symbol
    Scd1
  • Name
    stearoyl-Coenzyme A desaturase 1
  • Synonyms
    SCD, Scd-1, stearoyl-CoA desaturase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98239
    NCBI Gene: 20249
  • Gene Overview
    MyGene.info: SCD
Location & Maps
more
  • Sequence Map
    Chr19:44394451-44407709 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13259 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 37.98 cM
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCD, stearoyl-CoA desaturase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FADS5, hSCD1, MSTP008, SCD1, SCDOS
  • Links
    NCBI Gene ID: 6319
    neXtProt AC: NX_O00767, NX_Q9H354
    UniProt: O00767

  • Chr Location
    10q24.31; chr10:100347015-100364831 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 8 alleles in 9 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Gene trapped
    7
  • Spontaneous
    4
  • Targeted
    2
  • Transgenic
    2
  • Genomic Mutations
    1 involving Scd1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    15 strains or lines available
Homozygotes for targeted and spontaneous mutations exhibit alopecia, scaly skin, sebaceous gland hypoplasia, impaired ocular lubrication and synthesis and storage of triglycerides, higher lipid oxidation, reduced growth, and lower fertility in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    138
  • Tissues
    103
  • cDNA Data
    31
  • Literature Summary
    33
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037071 Ensembl Gene Model | MGI Sequence Detail 13259 C57BL/6J ±  kb
transcript ENSMUST00000041331 Ensembl | MGI Sequence Detail 4836 Not Applicable  
polypeptide ENSMUSP00000036936 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    79 from dbSNP Build 142
  • RFLP
    4
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 7
    cDNA 34
    Primer pair 5

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-1014, MGD-MRK-14305, MGD-MRK-14307, MGI:2147455, MGI:2147495, MGI:87858
References
more
  • Summaries
    All 182
    Developmental Gene Expression 33
    Gene Ontology 14
    Phenotypes 75
  • Earliest
    J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
  • Latest
    J:240923 Chen S, et al., Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory