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Sat1
Gene Detail
 Symbol
Name
ID
Sat1
spermidine/spermine N1-acetyl transferase 1
MGI:98233
Feature Type protein coding gene
Genetic Map
Chromosome X
72.38 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:155213132-155216449 bp, - strand
From VEGA annotation of GRCm38

  3318 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 3 zebrafish

Gene Tree: Sat1

Human
homologs
Human Homolog SAT1, spermidine/spermine N1-acetyltransferase 1
NCBI Gene ID 6303
neXtProt AC  NX_P21673
Human Synonyms  DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
Human Chr (Location)  Xp22.1; chrX:23783158-23786210 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SAT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Mice homozygous for a knock-out allele exhibit reduced female fertility, increased percent body fat and total fat pad weight, abnormal liver and white adipose tissue physiology, abnormal aerobic energy metabolism, increased serum leptin levels, and increased weight gain on a high-fat diet.
 
Interactions
Sat1 interacts with 103 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process polyamine catabolic process, polyamine metabolic process, ...
Component cytoplasm, cytosol, ...
Function diamine N-acetyltransferase activity, N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (153)    Tissues (117)    Images (39)
Theiler Stages: 11, 13, 15, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 137
RT-PCR 16
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(5) cDNA(15) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019352 (Evidence)
Ensembl Gene ModelENSMUSG00000025283 (Evidence)
Entrez Gene20229 (Evidence)
DFCITC1572883, TC1602994
DoTSDT.111023658, DT.487172, DT.536683
EC2.3.1.57
PDB3BJ7, 3BJ8
Consensus CDS ProjectCCDS30495.1
International Mouse Knockout Project StatusSat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019352 VEGA Gene Model | MGI Sequence Detail 3318 C57BL/6J ±  kb
transcript OTTMUST00000046202 VEGA | MGI Sequence Detail 896 Not Applicable 
polypeptide OTTMUSP00000020875 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR000182 GNAT domain
Protein Ontology PR:000014466 diamine acetyltransferase 1
References (Earliest) J:3224 de Meeus A, et al., A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV. Mamm Genome. 1992;3(11):637-43
(Latest) J:168466 Saiki R, et al., Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun. 2011 Jan 28;404(4):1044-9
All references(55)
Other
accession IDs
MGD-MRK-14295, MGI:2146776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory