Sat1
Gene Detail

Symbol Name ID

Sat1 spermidine/spermine N1-acetyl transferase 1 MGI:98233

Feature Type

protein coding gene

Genetic Map

Chromosome X

72.38 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:155213132-155216449 bp, - strand From VEGA annotation of GRCm38   3318 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 3 zebrafish

Gene Tree: Sat1

Human homologs

Human Homolog		SAT1, spermidine/spermine N1-acetyltransferase 1
NCBI Gene ID		6303
neXtProt AC		NX_P21673
Human Synonyms		DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
Human Chr (Location)		Xp22.1; chrX:23801275-23804327 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SAT1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit reduced female fertility, increased percent body fat and total fat pad weight, abnormal liver and white adipose tissue physiology, abnormal aerobic energy metabolism, increased serum leptin levels, and increased weight gain on a high-fat diet.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	polyamine metabolic process, regulation of cell proliferation, ...
Component	cytoplasm, intracellular
Function	diamine N-acetyltransferase activity, N-acetyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (153)    Tissues (116)    Images (39)
Theiler Stages: 11, 13, 15, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	137
RT-PCR	16

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(5) cDNA(15) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019352 (Evidence)
Ensembl Gene Model	ENSMUSG00000025283 (Evidence)
Entrez Gene	20229 (Evidence)
DFCI	TC1572883, TC1602994
DoTS	DT.111023658, DT.487172, DT.536683
EC	2.3.1.57
PDB	3BJ7, 3BJ8
Consensus CDS Project	CCDS30495.1
International Mouse Knockout Project Status	Sat1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019352	VEGA Gene Model | MGI Sequence Detail	3318	C57BL/6J
transcript	OTTMUST00000046202	VEGA | MGI Sequence Detail	896	Not Applicable
polypeptide	OTTMUSP00000020875	VEGA | MGI Sequence Detail	178	Not Applicable

All sequences(44) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR000182	GNAT domain
Protein Ontology	PR:000014466	diamine acetyltransferase 1

References

(Earliest) J:3224 de Meeus A, et al., A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV. Mamm Genome. 1992;3(11):637-43
(Latest) J:168466 Saiki R, et al., Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun. 2011 Jan 28;404(4):1044-9
All references(55)

Other accession IDs

MGD-MRK-14295, MGI:2146776