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Sat1 Gene Detail
Summary
  • Symbol
    Sat1
  • Name
    spermidine/spermine N1-acetyl transferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98233
    NCBI Gene: 20229
  • Gene Overview
    MyGene.info: SAT1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:155213132-155216449 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 72.38 cM, cytoband F3-F4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98233
protein coding gene ChrX:155213126-155216449 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036211
protein coding gene ChrX:153103851-153107157 (-)
A/J MGP_AJ_G0036181
protein coding gene ChrX:152381567-152384909 (-)
AKR/J MGP_AKRJ_G0036109
protein coding gene ChrX:157197064-157200494 (-)
BALB/cJ MGP_BALBcJ_G0036174
protein coding gene ChrX:150482660-150485969 (-)
C3H/HeJ MGP_C3HHeJ_G0035880
protein coding gene ChrX:153435941-153439245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036696
protein coding gene ChrX:157561336-157564651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033516
protein coding gene ChrX:143962810-143966111 (-)
CAST/EiJ MGP_CASTEiJ_G0035168
protein coding gene ChrX:132597582-132601175 (-)
CBA/J MGP_CBAJ_G0035855
protein coding gene ChrX:162048955-162052272 (-)
DBA/2J MGP_DBA2J_G0036021
protein coding gene ChrX:151385915-151389229 (-)
FVB/NJ MGP_FVBNJ_G0035951
protein coding gene ChrX:150496522-150499832 (-)
LP/J MGP_LPJ_G0036106
protein coding gene ChrX:154199052-154202366 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035984
protein coding gene ChrX:170411471-170414783 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036737
protein coding gene ChrX:152683855-152687195 (-)
PWK/PhJ MGP_PWKPhJ_G0034866
protein coding gene ChrX:129584832-129588195 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034687
protein coding gene ChrX:133048797-133051873 (-)
WSB/EiJ MGP_WSBEiJ_G0035303
protein coding gene ChrX:150680810-150684120 (-)



Homology
more
  • Human Ortholog
    SAT1, spermidine/spermine N1-acetyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SAT1, spermidine/spermine N1-acetyltransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
  • Links
    NCBI Gene ID: 6303
    neXtProt AC: NX_P21673
    UniProt: P21673

  • Chr Location
    Xp22.11; chrX:23783158-23786223 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility, increased percent body fat and total fat pad weight, abnormal liver and white adipose tissue physiology, abnormal aerobic energy metabolism, increased serum leptin levels, and increased weight gain on a high-fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025283 Ensembl Gene Model | MGI Sequence Detail 3318 C57BL/6J ±  kb
    transcript ENSMUST00000112551 Ensembl | MGI Sequence Detail 896 Not Applicable  
    polypeptide ENSMUSP00000108170 Ensembl | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 5
      cDNA 16
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14295, MGI:2146776
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:3224 de Meeus A, et al., A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV. Mamm Genome. 1992;3(11):637-43
    • Latest
      J:259186 Heng X, et al., Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory