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Apcs
Gene Detail
 Symbol
Name
ID
Apcs
serum amyloid P-component
MGI:98229
Synonyms Sap
Feature Type protein coding gene
Genetic Map
Chromosome 1
80.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr1:172893962-172895054 bp, - strand
From Ensembl annotation of GRCm38

  1093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: C-reactive protein
Gene Tree: Apcs

Human
homologs
Human Homolog APCS, amyloid P component, serum
NCBI Gene ID 325
neXtProt AC  NX_P02743
Human Synonyms  HEL-S-92n, PTX2, SAP
Human Chr (Location)  1q21-q23; chr1:159587826-159588871 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased antibody productions, increased autoimmune antibodies, reduced amyloidosis and glomerulonephrosis depending on strain background.
 
Interactions
Apcs interacts with 33 markers (Mir27a, Mir96, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process innate immune response, negative regulation of exo-alpha-sialidase activity, ...
Component blood microparticle, extracellular matrix, ...
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 18, 22, 28
Assay TypeResults
RNA in situ 3
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) Genomic(27) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026542 (Evidence)
Entrez Gene20219 (Evidence)
UniGene330510
DFCITC1583277
DoTSDT.493184
NIA Mouse Gene IndexU022078
Consensus CDS ProjectCCDS15520.1
International Mouse Knockout Project StatusApcs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026542 Ensembl Gene Model | MGI Sequence Detail 1093 C57BL/6J ±  kb
transcript ENSMUST00000027824 Ensembl | MGI Sequence Detail 983 Not Applicable 
polypeptide ENSMUSP00000027824 Ensembl | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(9) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000004126 serum amyloid P-component
References (Earliest) J:8069 Mortensen RF, et al., Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics. 1985;22(4):367-75
(Latest) J:189442 Crawford JR, et al., FcgammaRI mediates serum amyloid P inhibition of fibrocyte differentiation. J Leukoc Biol. 2012 Oct;92(4):699-711
All references(72)
Other
accession IDs
MGD-MRK-14288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory