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Apcs Gene Detail
Summary
  • Symbol
    Apcs
  • Name
    serum amyloid P-component
  • Synonyms
    Sap
  • Feature Type
    protein coding gene
  • IDs
    MGI:98229
    NCBI Gene: 20219
  • Gene Overview
    MyGene.info: APCS
Location & Maps
more
  • Sequence Map
    Chr1:172893961-172895041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1081 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    32 experiments
Homology
more
  • Human Ortholog
    APCS, amyloid P component, serum
  • Vertebrate Orthologs
    6
  • Human Ortholog
    APCS, amyloid P component, serum
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-92n, PTX2, SAP
  • Links
    NCBI Gene ID: 325
    neXtProt AC: NX_P02743

  • Chr Location
    1q21-q23; chr1:159587826-159588871 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Targeted
    4
  • Genomic Mutations
    2 involving Apcs
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased antibody productions, increased autoimmune antibodies, reduced amyloidosis and glomerulonephrosis depending on strain background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050160 VEGA Gene Model | MGI Sequence Detail 1081 C57BL/6J ±  kb
transcript OTTMUST00000127516 VEGA | MGI Sequence Detail 971 Not Applicable  
polypeptide OTTMUSP00000068771 VEGA | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    112 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004126 serum amyloid P-component
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentaxin-related
Molecular
Reagents
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  • All nucleic 61
    Genomic 27
    cDNA 32
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14288
References
more
  • Summaries
    All 67
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:8069 Mortensen RF, et al., Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics. 1985;22(4):367-75
  • Latest
    J:215033 Pilling D, et al., Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One. 2014;9(4):e93730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory