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Apcs
Gene Detail
Symbol

Name
ID
Apcs
serum amyloid P-component
MGI:98229
Synonyms
Sap
Feature Type
protein coding gene
Genetic Map
Chromosome 1
80.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr1:172893961-172895041 bp, - strand
From VEGA annotation of GRCm38

  1081 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: APCS
Protein SuperFamily: C-reactive protein
Gene Tree: Apcs

Human
homologs
APCS, amyloid P component, serum
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 325
neXtProt AC: NX_P02743

Human Synonyms: HEL-S-92n, PTX2, SAP

Human Chr (Location): 1q21-q23; chr1:159587826-159588871 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased antibody productions, increased autoimmune antibodies, reduced amyloidosis and glomerulonephrosis depending on strain background.
 
Interactions
Apcs interacts with 33 markers (Mir27a, Mir96, Mir98, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apcs, LOC100485832    NEW 
Molecular
reagents
All nucleic(61) Genomic(27) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050160 (Evidence)
Ensembl Gene Model ENSMUSG00000026542 (Evidence)
Entrez Gene 20219 (Evidence)
UniGene 330510
DFCI TC1583277
DoTS DT.493184
NIA Mouse Gene Index U022078
Consensus CDS Project CCDS15520.1
International Mouse Phenotyping Consortium Status Apcs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050160 VEGA Gene Model | MGI Sequence Detail 1081 C57BL/6J ±  kb
transcript OTTMUST00000127516 VEGA | MGI Sequence Detail 971 Not Applicable 
polypeptide OTTMUSP00000068771 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(9) : SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000004126 serum amyloid P-component
References
(Earliest) J:8069 Mortensen RF, et al., Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics. 1985;22(4):367-75
(Latest) J:215033 Pilling D, et al., Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One. 2014;9(4):e93730
All references(70)
Other
accession IDs
MGD-MRK-14288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory