Sag
Gene Detail

Symbol Name ID

Sag retinal S-antigen MGI:98227

Synonyms

A930001K18Rik, Arr1, arrestin, arrestin 1, rod arrestin, visual arrestin 1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr1:87803680-87845158 bp, + strand From VEGA annotation of GRCm38   41479 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:455  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arrestin
Gene Tree: Sag

Human homologs

Human Homolog		SAG, S-antigen; retina and pineal gland (arrestin)
NCBI Gene ID		6295
neXtProt AC		NX_P10523
Human Synonyms		RP47, S-AG
Human Chr (Location)		2q37.1; chr2:234216309-234255701 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SAG

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	response to stimulus, signal transduction, ...
Component	photoreceptor inner segment, photoreceptor outer segment
Function	opsin binding, phosphoprotein binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (15)    Images (23)
Theiler Stages: 15, 17, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
RNA in situ	16
RT-PCR	20

cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) Genomic(8) cDNA(128) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021826 (Evidence)
Ensembl Gene Model	ENSMUSG00000056055 (Evidence)
Entrez Gene	20215 (Evidence)
UniGene	1276
DFCI	TC1576481, TC1591750, TC1593170, TC1601143
DoTS	DT.110906535, DT.40167216, DT.91381839, DT.91416114, DT.91427281
NIA Mouse Gene Index	U000566
Consensus CDS Project	CCDS35656.1
International Mouse Knockout Project Status	Sag

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021826	VEGA Gene Model | MGI Sequence Detail	41479	C57BL/6J
transcript	OTTMUST00000051793	VEGA | MGI Sequence Detail	1719	Not Applicable
polypeptide	OTTMUSP00000024441	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(4) : SNPs(183 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000698	Arrestin
InterPro	IPR017864	Arrestin, conserved site
InterPro	IPR014752	Arrestin, C-terminal
InterPro	IPR011022	Arrestin C-terminal-like domain
InterPro	IPR011021	Arrestin-like, N-terminal
InterPro	IPR014753	Arrestin, N-terminal
InterPro	IPR014756	Immunoglobulin E-set
Protein Ontology	PR:000014434	S-arrestin

References

(Earliest) J:19280 Tsuda M, et al., Structural analysis of mouse S-antigen. Gene. 1988 Dec 15;73(1):11-20
(Latest) J:175851 Cleghorn WM, et al., Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery. PLoS One. 2011;6(7):e22797
All references(83)

Other accession IDs

MGD-MRK-14285, MGI:2442817