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Sag
Gene Detail
 Symbol
Name
ID
Sag
S-antigen, retina and pineal gland (arrestin)
MGI:98227
Synonyms A930001K18Rik, Arr1, arrestin, arrestin 1, rod arrestin, visual arrestin 1
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr1:87803680-87845158 bp, + strand
From VEGA annotation of GRCm38

  41479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:455  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: arrestin
Gene Tree: Sag

Human
homologs
Human Homolog SAG, S-antigen; retina and pineal gland (arrestin)
NCBI Gene ID 6295
neXtProt AC  NX_P10523
Human Synonyms  RP47, S-AG
Human Chr (Location)  2q37.1; chr2:233307663-233347055 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SAG
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormalities in retinal rod cell outer segment morphology and rod electrophysiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process response to stimulus, signal transduction, ...
Component photoreceptor inner segment, photoreceptor outer segment
Function opsin binding, phosphoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (15)    Images (23)
Theiler Stages: 15, 17, 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 16
RT-PCR 20
cDNA source data(128)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(139) Genomic(8) cDNA(129) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021826 (Evidence)
Ensembl Gene ModelENSMUSG00000056055 (Evidence)
Entrez Gene20215 (Evidence)
UniGene1276
DFCITC1576481, TC1591750, TC1593170, TC1601143
DoTSDT.110906535, DT.40167216, DT.91381839, DT.91416114, DT.91427281
NIA Mouse Gene IndexU000566
Consensus CDS ProjectCCDS35656.1
International Mouse Knockout Project StatusSag
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021826 VEGA Gene Model | MGI Sequence Detail 41479 C57BL/6J ±  kb
transcript OTTMUST00000051793 VEGA | MGI Sequence Detail 1719 Not Applicable 
polypeptide OTTMUSP00000024441 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(6)
Polymorphisms RFLP(4) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000698 Arrestin
InterPro IPR017864 Arrestin, conserved site
InterPro IPR014752 Arrestin, C-terminal
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014753 Arrestin, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000014434 S-arrestin
References (Earliest) J:19280 Tsuda M, et al., Structural analysis of mouse S-antigen. Gene. 1988 Dec 15;73(1):11-20
(Latest) J:199579 Papal S, et al., The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet. 2013 Sep 15;22(18):3773-88
All references(88)
Other
accession IDs
MGD-MRK-14285, MGI:2442817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory