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Saa2
Gene Detail
Symbol

Name
ID
Member of
Saa2
serum amyloid A 2
MGI:98222
Saa cluster
STS
Synonyms
Saa-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
30.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:46751833-46754314 bp, + strand
From Ensembl annotation of GRCm38

  2482 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128033  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee; 2 rhesus macaque; 3 cattle; 3 dog; 1 zebrafish

Protein SuperFamily: amyloid protein, SAA type
Gene Tree: Saa2

Human
homologs
Human Homolog SAA1, serum amyloid A1
NCBI Gene ID 6288
neXtProt AC  NX_P0DJI8
Human Synonyms  PIG4, SAA, SAA2, TP53I4
Human Chr (Location)  11p15.1; chr11:18266261-18269977 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
The CE/J strain produces a mutant form of Saa2 and is not susceptible to amyloidosis, as are mice of most other inbred strains. M. caroli, M. spretus and M.m. Czech produce variant Saa2 isoforms and M.m. Czech is also reistant to amyloidosis.
 
Interactions
Saa2 interacts with 14 markers (Mir136, Mir181b-2, Mir202, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process acute-phase response
Component extracellular region, extracellular vesicular exosome, ...
Function G-protein coupled receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(7) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000057465 (Evidence)
Entrez Gene20209 (Evidence)
UniGene200941
DoTSDT.488943
Consensus CDS ProjectCCDS21285.1
International Mouse Knockout Project StatusSaa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057465 Ensembl Gene Model | MGI Sequence Detail 2482 C57BL/6J ±  kb
transcript ENSMUST00000075982 Ensembl | MGI Sequence Detail 610 Not Applicable 
polypeptide ENSMUSP00000075365 Ensembl | MGI Sequence Detail 122 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(157 from dbSNP Build 137)    SNPs within 2kb including multiple locations(203)
Protein-related
information
ResourceIDDescription
InterPro IPR000096 Serum amyloid A protein
Protein Ontology PR:000034986 murine-type serum amyloid A-2 protein
References
(Earliest) J:6644 Morrow JF, et al., Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718-22
(Latest) J:191471 Chiba T, et al., Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1326-32
All references(43)
Other
accession IDs
MGD-MRK-14274, MGD-MRK-14279, MGI:2142205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory