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Saa2 Gene Detail
Summary
  • Symbol
    Saa2
  • Name
    serum amyloid A 2
  • Synonyms
    Saa-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98222
    NCBI Gene: 20209
  • Member of
    Saa cluster
  • Gene Overview
    MyGene.info: SAA1
Location & Maps
more
  • Sequence Map
    Chr7:46751833-46754314 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2482 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SAA1, serum amyloid A1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    SAA1, serum amyloid A1
    Orthology source: HomoloGene
  • Synonyms
    PIG4, SAA, SAA2, TP53I4
  • Links
    NCBI Gene ID: 6288
    neXtProt AC: NX_P0DJI8

  • Chr Location
    11p15.1; chr11:18266261-18269977 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    3
  • Targeted
    1
  • Incidental Mutations
The CE/J strain produces a mutant form of Saa2 and is not susceptible to amyloidosis, as are mice of most other inbred strains. M. caroli, M. spretus and M.m. Czech produce variant Saa2 isoforms and M.m. Czech is also reistant to amyloidosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057465 Ensembl Gene Model | MGI Sequence Detail 2482 C57BL/6J ±  kb
transcript ENSMUST00000075982 Ensembl | MGI Sequence Detail 610 Not Applicable  
polypeptide ENSMUSP00000075365 Ensembl | MGI Sequence Detail 122 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000034986 murine-type serum amyloid A-2 protein
  • InterPro Domains
    IPR000096 Serum amyloid A protein
Molecular
Reagents
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  • All nucleic 39
    Genomic 7
    cDNA 30
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-14274, MGD-MRK-14279, MGI:2142205
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:6644 Morrow JF, et al., Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718-22
  • Latest
    J:225536 Vaisar T, et al., Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. J Lipid Res. 2015 Aug;56(8):1519-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory