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Saa2 Gene Detail
Summary
  • Symbol
    Saa2
  • Name
    serum amyloid A 2
  • Synonyms
    Saa-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98222
    NCBI Gene: 20209
  • Member of
    Saa cluster
  • Gene Overview
    MyGene.info: SAA1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46751790-46754313 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.56 cM
  • Mapping Data
    7 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98222
protein coding gene Chr7:46751769-46754314 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032270
protein coding gene Chr7:47134118-47138776 (-)
A/J MGP_AJ_G0032250
protein coding gene Chr7:46172978-46177672 (+)
AKR/J MGP_AKRJ_G0032186
protein coding gene Chr7:47462298-47468883 (+)
BALB/cJ MGP_BALBcJ_G0032261
protein coding gene Chr7:46161616-46165074 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029767
protein coding gene Chr7:48701556-48704055 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0032050
protein coding gene Chr7:45637901-45641033 (-)
LP/J MGP_LPJ_G0032178
protein coding gene Chr7:47849478-47852212 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032088
protein coding gene Chr7:49671974-49674455 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032768
protein coding gene Chr7:46672210-46675290 (-)
PWK/PhJ MGP_PWKPhJ_G0031032
protein coding gene Chr7:39367169-39369021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030865
protein coding gene Chr7:34693581-34695609 (-)
WSB/EiJ MGP_WSBEiJ_G0031422
protein coding gene Chr7:47173799-47177466 (-)



Homology
more
  • Human Ortholog
    SAA1, serum amyloid A1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    SAA1, serum amyloid A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIG4, SAA, SAA2, TP53I4
  • Links
    NCBI Gene ID: 6288
    neXtProt AC: NX_P0DJI8
    UniProt: P0DJI8

  • Chr Location
    11p15.1; chr11:18266225-18269977 (+)  GRCh38.p7

  • Human Ortholog
    SAA2, serum amyloid A2
    Orthology source: HGNC
  • Synonyms
    SAA, SAA1
  • Links
    NCBI Gene ID: 6289
    neXtProt AC: NX_P0DJI9
    UniProt: P0DJI9

  • Chr Location
    11p15.1; chr11:18238233-18248674 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The CE/J strain produces a mutant form of Saa2 and is not susceptible to amyloidosis, as are mice of most other inbred strains. M. caroli, M. spretus and M.m. Czech produce variant Saa2 isoforms and M.m. Czech is also reistant to amyloidosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057465 Ensembl Gene Model | MGI Sequence Detail 2524 C57BL/6J ±  kb
    transcript ENSMUST00000075982 Ensembl | MGI Sequence Detail 606 Not Applicable  
    polypeptide ENSMUSP00000075365 Ensembl | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 7
      cDNA 31
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14274, MGD-MRK-14279, MGI:2142205
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:6644 Morrow JF, et al., Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718-22
    • Latest
      J:274344 Lee JW, et al., Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019 Mar;567(7747):249-252

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory