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Saa1
Gene Detail
 Symbol
Name
ID
Member of
Saa1
serum amyloid A 1
MGI:98221
Saa cluster
STS D7Mit28
Synonyms Saa-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
30.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr7:46740501-46742980 bp, - strand
From VEGA annotation of GRCm38

  2480 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128033  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee; 2 rhesus macaque; 3 cattle; 3 dog; 1 zebrafish

Protein SuperFamily: amyloid protein, SAA type
Gene Tree: Saa1

Human
homologs
Human Homolog SAA1, serum amyloid A1
NCBI Gene ID 6288
neXtProt AC  NX_P0DJI8
Human Synonyms  PIG4, SAA, SAA2, TP53I4
Human Chr (Location)  11p15.1; chr11:18266261-18269977 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
 
Male mice homozygous for a knock-out of SAA1 and SAA2 exhibit increased serum cholesterol in LPS-treated.
 
Interactions
Saa1 interacts with 33 markers (Mir33, Mir98, Mir196a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process acute-phase response, cholesterol metabolic process
Component extracellular region, extracellular space, ...
Function G-protein coupled receptor binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (16)    Images (1)
Theiler Stages: 18, 22, 28
Assay TypeResults
RNA in situ 16
RT-PCR 2
cDNA source data(27)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(6) cDNA(29) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033491 (Evidence)
Ensembl Gene ModelENSMUSG00000074115 (Evidence)
Entrez Gene20208 (Evidence)
UniGene148800
DoTSDT.101708319, DT.94127234
Consensus CDS ProjectCCDS21284.1
International Mouse Knockout Project StatusSaa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033491 VEGA Gene Model | MGI Sequence Detail 2480 C57BL/6J ±  kb
transcript OTTMUST00000084216 VEGA | MGI Sequence Detail 605 Not Applicable 
polypeptide OTTMUSP00000045357 VEGA | MGI Sequence Detail 122 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(3)
Polymorphisms RFLP(9) : SNPs within 2kb(136 from dbSNP Build 137)    SNPs within 2kb including multiple locations(182)
Protein-related
information
ResourceIDDescription
InterPro IPR000096 Serum amyloid A protein
Protein Ontology PR:000015918 serum amyloid A-1 protein
References (Earliest) J:31043 Johnson PM, et al., Identification in human placentae of antigenic activity related to the amyloid serum protein SAA. Scand J Immunol. 1977;6(4):319-25
(Latest) J:191471 Chiba T, et al., Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1326-32
All references(51)
Other
accession IDs
MGD-MRK-14273, MGD-MRK-14278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory