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Saa1 Gene Detail
Summary
  • Symbol
    Saa1
  • Name
    serum amyloid A 1
  • Synonyms
    Saa-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98221
    NCBI Gene: 20208
  • Member of
    Saa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46389921-46392404 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.54 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98221
 protein coding gene Chr7:46389921-46392404 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032271
 protein coding gene Chr7:47134123-47138776 (-)
A/J MGP_AJ_G0032249
 protein coding gene Chr7:46172978-46176666 (+)
AKR/J MGP_AKRJ_G0032185
 protein coding gene Chr7:47462298-47468878 (+)
BALB/cJ MGP_BALBcJ_G0032262
 protein coding gene Chr7:46161621-46165074 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029768
 protein coding gene Chr7:48701561-48704055 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0032051
 protein coding gene Chr7:45637906-45641033 (-)
LP/J MGP_LPJ_G0032177
 protein coding gene Chr7:47849478-47852207 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032087
 protein coding gene Chr7:49665854-49668330 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032769
 protein coding gene Chr7:46672215-46675290 (-)
PWK/PhJ MGP_PWKPhJ_G0031031
 protein coding gene Chr7:39367169-39369018 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030866
 protein coding gene Chr7:34693586-34695640 (-)
WSB/EiJ MGP_WSBEiJ_G0031423
 protein coding gene Chr7:47173804-47177466 (-)



Homology
more
  • Human Ortholog
    SAA1, serum amyloid A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAA1, serum amyloid A1
  • Synonyms
    PIG4, SAA, SAA2, TP53I4
  • Links
    NCBI Gene ID: 6288
    neXtProt AC: NX_P0DJI8
    UniProt: P0DJI8

  • Chr Location
    11p15.1; chr11:18266260-18269977 (+)  GRCh38
  • Human Ortholog
    SAA2, serum amyloid A2
  • Synonyms
    SAA, SAA1
  • Links
    NCBI Gene ID: 6289
    neXtProt AC: NX_P0DJI9
    UniProt: P0DJI9

  • Chr Location
    11p15.1; chr11:18238236-18248668 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotype references
Male mice homozygous for a knock-out of SAA1 and SAA2 exhibit increased serum cholesterol in LPS-treated.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    27
  • cDNA Data
    27
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20208 NCBI Gene Model | MGI Sequence Detail 2484 C57BL/6J ±  kb
transcript NM_001403085 RefSeq | MGI Sequence Detail 828 ZRU/MplStud  
polypeptide P05366 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    Genomic 6
    cDNA 29
    Primer pair 2
    Other 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14273, MGD-MRK-14278
References
more
  • Summaries
    All 96
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:31043 Johnson PM, et al., Identification in human placentae of antigenic activity related to the amyloid serum protein SAA. Scand J Immunol. 1977;6(4):319-25
  • Latest
    J:345323 Xiao Y, et al., SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-kappaB/p38/JNK and TGFbeta/Smad pathways. FASEB J. 2023 May;37(5):e22911
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory