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Rxrg Gene Detail
Summary
  • Symbol
    Rxrg
  • Name
    retinoid X receptor gamma
  • Synonyms
    Nr2b3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98216
    NCBI Gene: 20183
  • Gene Overview
    MyGene.info: RXRG
Location & Maps
more
  • Sequence Map
    Chr1:167598384-167639623 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41240 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RXRG, retinoid X receptor gamma
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RXRG, retinoid X receptor gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NR2B3, RXRC
  • Links
    NCBI Gene ID: 6258
    neXtProt AC: NX_P48443

  • Chr Location
    1q22-q23; chr1:165400922-165445355 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Rxrg
  • Incidental Mutations
Targeted disruption of exon 2 causes a 25% reduction of neurons in the striatum and may lead to premature death and altered responses to the administration of dopamine antagonists on some genetic backgrounds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022560 VEGA Gene Model | MGI Sequence Detail 41240 C57BL/6J ±  kb
transcript OTTMUST00000054044 VEGA | MGI Sequence Detail 2110 Not Applicable  
polypeptide OTTMUSP00000025737 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    542 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014374 retinoic acid receptor RXR-gamma
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR021780 Nuclear/hormone receptor activator site AF-1
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR000003 Retinoid X receptor/HNF4
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 46
    Genomic 7
    cDNA 33
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14266
References
more
  • Summaries
    All 131
    Developmental Gene Expression 64
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
  • Latest
    J:224771 Ruhl R, et al., 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. PLoS Genet. 2015 Jun;11(6):e1005213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory