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Rxrb
Gene Detail
 Symbol
Name
ID
Rxrb
retinoid X receptor beta
MGI:98215
Synonyms H-2RIIBP, Nr2b2, RCoR-1, Rub
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr17:34031812-34038393 bp, + strand
From VEGA annotation of GRCm38

  6582 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Rxrb

Human
homologs
Human Homolog RXRB, retinoid X receptor, beta
NCBI Gene ID 6257
neXtProt AC  NX_P28702
Human Synonyms  DAUDI6, H-2RIIBP, NR2B2, RCoR-1
Human Chr (Location)  6p21.3; chr6:33193585-33200696 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice homozygous for a null mutation exhibit partial embryonic and perinatal lethality, and surviving adult males are sterile due to defects in spermatogenesis.
 
Phenotype Images(4)
Interactions
Rxrb interacts with 122 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cardiac muscle cell proliferation, cellular response to retinoic acid, ...
Component nucleus
Function 9-cis retinoic acid receptor activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (282)    Tissues (133)    Images (25)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 184
Northern blot 18
Western blot 2
RT-PCR 77
cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) Genomic(14) cDNA(96) Primer pair(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037107 (Evidence)
Ensembl Gene ModelENSMUSG00000039656 (Evidence)
Entrez Gene20182 (Evidence)
UniGene1243
DFCITC1577451, TC1589111, TC1637534, TC1773168
NIA Mouse Gene IndexU043589
Consensus CDS ProjectCCDS57066.1, CCDS57067.1, CCDS57068.1
International Mouse Knockout Project StatusRxrb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037107 VEGA Gene Model | MGI Sequence Detail 6582 C57BL/6J ±  kb
transcript OTTMUST00000095534 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000053307 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021780 Nuclear/hormone receptor activator site AF-1
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR000003 Retinoid X receptor/HNF4
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000014373 retinoic acid receptor RXR-beta
References (Earliest) J:19805 Hamada K, et al., H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8289-93
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(133)
Other
accession IDs
MGD-MRK-14265, MGI:2146953

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory