Rrm1 MGI Mouse Gene Detail - MGI:98180 - ribonucleotide reductase M1

Symbol

Rrm1
Name

ribonucleotide reductase M1
Synonyms

RnrM1

Feature Type

protein coding gene
IDs

MGI:98180
NCBI Gene: 20133
Gene Overview

MyGene.info: RRM1
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:102441695-102469771 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.72 cM
Mapping Data

3 experiments

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98180	protein coding gene	Chr7:102441695-102469771 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032608	protein coding gene	Chr7:105498433-105528192 (+)
A/J	MGP_AJ_G0032584	protein coding gene	Chr7:102799543-102827147 (+)
AKR/J	MGP_AKRJ_G0032520	protein coding gene	Chr7:105259238-105289795 (+)
BALB/cJ	MGP_BALBcJ_G0032595	protein coding gene	Chr7:102501071-102528721 (+)
C3H/HeJ	MGP_C3HHeJ_G0032309	protein coding gene	Chr7:105656893-105685091 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033092	protein coding gene	Chr7:109456567-109489031 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030086	protein coding gene	Chr7:105147294-105175426 (+)
CAST/EiJ	MGP_CASTEiJ_G0031635	protein coding gene	Chr7:97206738-97237143 (+)
CBA/J	MGP_CBAJ_G0032275	protein coding gene	Chr7:113292410-113332423 (+)
DBA/2J	MGP_DBA2J_G0032427	protein coding gene	Chr7:101123624-101151082 (+)
FVB/NJ	MGP_FVBNJ_G0032383	protein coding gene	Chr7:100906437-100934145 (+)
LP/J	MGP_LPJ_G0032516	protein coding gene	Chr7:106804067-106833103 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032417	protein coding gene	Chr7:114558158-114588040 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033114	protein coding gene	Chr7:104546094-104573165 (+)
PWK/PhJ	MGP_PWKPhJ_G0031353	protein coding gene	Chr7:94246655-94275006 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031197	protein coding gene	Chr7:91835285-91862785 (+)
WSB/EiJ	MGP_WSBEiJ_G0031752	protein coding gene	Chr7:105220341-105248906 (+)

Human Ortholog

RRM1, ribonucleotide reductase catalytic subunit M1

Vertebrate Orthologs

10

Human Ortholog

RRM1, ribonucleotide reductase catalytic subunit M1
Orthology source: HomoloGene, HGNC
Synonyms

R1, RIR1, RR1
Links

HGNC:10451

NCBI Gene ID: 6240

neXtProt AC: NX_P23921

UniProt: P23921
Chr Location

11p15.4; chr11:4094685-4138925 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 806
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RRM1
Protein SuperFamily

ribonucleoside-diphosphate reductase class I, large subunit
Gene Tree

Rrm1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Gene trapped

17
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Rrm1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5.

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All GO Annotations

29
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

412
Tissues

125
cDNA Data

19
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rrm1

ZFIN rrm1

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Rrm1 interacts with 206 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

71
RefSeq

2
UniProt

5
CCDS

CCDS40049.1

Ensembl

ENSMUSG00000030978 (Evidence)
NCBI Gene

20133

			Length	Strain/Species	Flank
genomic	20133	NCBI Gene Model \| MGI Sequence Detail	28077	C57BL/6J	± kb
transcript	NM_009103	RefSeq \| MGI Sequence Detail	3997	C57BL/6
polypeptide	P07742	UniProt \| EBI \| MGI Sequence Detail	792	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014305 ribonucleoside-diphosphate reductase large subunit

(term hierarchy)
EC

1.17.4.1
InterPro Domains

IPR005144 ATP-cone domain

IPR039718 Ribonucleoside-diphosphate reductase large subunit

IPR013346 Ribonucleotide reductase, class I , alpha subunit

IPR000788 Ribonucleotide reductase large subunit, C-terminal

IPR013509 Ribonucleotide reductase large subunit, N-terminal

IPR008926 Ribonucleotide reductase R1 subunit, N-terminal

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All nucleic 29

Genomic 8

cDNA 20

Primer pair 1

Microarray probesets 5

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MGD-MRK-14209

Summaries

All 66

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 19
Earliest

J:7868 Caras IW, et al., Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem. 1985 Jun 10;260(11):7015-22
Latest

J:267889 Moon S, et al., Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018 Nov 2;9(11):1118

TSS for Rrm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68342	Chr7:102441685-102441698 (+)	-3 bp
Tssr68343	Chr7:102441745-102441756 (+)	56 bp
Tssr68344	Chr7:102441776-102441825 (+)	106 bp
Tssr68345	Chr7:102441831-102441888 (+)	165 bp
Tssr68346	Chr7:102441911-102441963 (+)	242 bp
Tssr68347	Chr7:102442683-102442693 (+)	993 bp
Tssr68348	Chr7:102442732-102442752 (+)	1,047 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/18/2019 MGI 6.14