Rrm1 MGI Mouse Gene Detail - MGI:98180 - ribonucleotide reductase M1

Rrm1 Gene Detail

Symbol

Rrm1
Name

ribonucleotide reductase M1
Synonyms

RnrM1

Feature Type

protein coding gene
IDs

MGI:98180
NCBI Gene: 20133
Gene Overview

MyGene.info: RRM1

Sequence Map

Chr7:102441695-102469771 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

28077 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.72 cM
Mapping Data

3 experiments

Human Ortholog

RRM1, ribonucleotide reductase catalytic subunit M1

Vertebrate Orthologs

10

Human Ortholog

RRM1, ribonucleotide reductase catalytic subunit M1
Orthology source: HomoloGene, HGNC
Synonyms

R1, RIR1, RR1
Links

HGNC:10451

NCBI Gene ID: 6240

neXtProt AC: NX_P23921
Chr Location

11p15.5; chr11:4094561-4138881 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 806
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RRM1
Protein SuperFamily

ribonucleoside-diphosphate reductase class I, large subunit
Gene Tree

Rrm1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Gene trapped

17
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Rrm1
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5.

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All GO Annotations

24
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

412
Tissues

125
cDNA Data

18
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase rrm1

ZFIN rrm1

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Rrm1 interacts with 206 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

62
RefSeq

2
UniProt

3
CCDS

CCDS40049.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000060506	VEGA Gene Model \| MGI Sequence Detail	28077	C57BL/6J	± kb
transcript	OTTMUST00000148020	VEGA \| MGI Sequence Detail	3997	Not Applicable
polypeptide	OTTMUSP00000076994	VEGA \| MGI Sequence Detail	792	Not Applicable

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SNPs within 2kb

527 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000014305 ribonucleoside-diphosphate reductase large subunit
EC

1.17.4.1
InterPro Domains

IPR005144 ATP-cone domain

IPR013346 Ribonucleotide reductase, class I , alpha subunit

IPR000788 Ribonucleotide reductase large subunit, C-terminal

IPR013509 Ribonucleotide reductase large subunit, N-terminal

IPR008926 Ribonucleotide reductase R1 subunit, N-terminal

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All nucleic 28

Genomic 8

cDNA 19

Primer pair 1

Microarray probesets 5

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MGD-MRK-14209

Summaries

All 49

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 19
Earliest

J:7868 Caras IW, et al., Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem. 1985 Jun 10;260(11):7015-22
Latest

J:228239 Specks J, et al., A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015 Sep 1;35(17):2910-7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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