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Rrm1 Gene Detail
Summary
  • Symbol
    Rrm1
  • Name
    ribonucleotide reductase M1
  • Synonyms
    RnrM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98180
    NCBI Gene: 20133
  • Gene Overview
    MyGene.info: RRM1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:102441695-102469771 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98180
protein coding gene Chr7:102441695-102469771 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032608
protein coding gene Chr7:105498433-105528192 (+)
A/J MGP_AJ_G0032584
protein coding gene Chr7:102799543-102827147 (+)
AKR/J MGP_AKRJ_G0032520
protein coding gene Chr7:105259238-105289795 (+)
BALB/cJ MGP_BALBcJ_G0032595
protein coding gene Chr7:102501071-102528721 (+)
C3H/HeJ MGP_C3HHeJ_G0032309
protein coding gene Chr7:105656893-105685091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033092
protein coding gene Chr7:109456567-109489031 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030086
protein coding gene Chr7:105147294-105175426 (+)
CAST/EiJ MGP_CASTEiJ_G0031635
protein coding gene Chr7:97206738-97237143 (+)
CBA/J MGP_CBAJ_G0032275
protein coding gene Chr7:113292410-113332423 (+)
DBA/2J MGP_DBA2J_G0032427
protein coding gene Chr7:101123624-101151082 (+)
FVB/NJ MGP_FVBNJ_G0032383
protein coding gene Chr7:100906437-100934145 (+)
LP/J MGP_LPJ_G0032516
protein coding gene Chr7:106804067-106833103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032417
protein coding gene Chr7:114558158-114588040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033114
protein coding gene Chr7:104546094-104573165 (+)
PWK/PhJ MGP_PWKPhJ_G0031353
protein coding gene Chr7:94246655-94275006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031197
protein coding gene Chr7:91835285-91862785 (+)
WSB/EiJ MGP_WSBEiJ_G0031752
protein coding gene Chr7:105220341-105248906 (+)



Homology
more
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    R1, RIR1, RR1
  • Links
    NCBI Gene ID: 6240
    neXtProt AC: NX_P23921
    UniProt: P23921

  • Chr Location
    11p15.4; chr11:4094685-4138925 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20133 NCBI Gene Model | MGI Sequence Detail 28077 C57BL/6J ±  kb
    transcript NM_009103 RefSeq | MGI Sequence Detail 3997 C57BL/6  
    polypeptide P07742 UniProt | EBI | MGI Sequence Detail 792 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000014305 ribonucleoside-diphosphate reductase large subunit
    • EC
    • InterPro Domains
      IPR005144 ATP-cone domain
      IPR039718 Ribonucleoside-diphosphate reductase large subunit
      IPR013346 Ribonucleotide reductase, class I , alpha subunit
      IPR000788 Ribonucleotide reductase large subunit, C-terminal
      IPR013509 Ribonucleotide reductase large subunit, N-terminal
      IPR008926 Ribonucleotide reductase R1 subunit, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 8
      cDNA 20
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14209
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:7868 Caras IW, et al., Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem. 1985 Jun 10;260(11):7015-22
    • Latest
      J:267889 Moon S, et al., Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018 Nov 2;9(11):1118

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory