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Rrm1 Gene Detail
Summary
  • Symbol
    Rrm1
  • Name
    ribonucleotide reductase M1
  • Synonyms
    RnrM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98180
    NCBI Gene: 20133
  • Gene Overview
    MyGene.info: RRM1
Location & Maps
more
  • Sequence Map
    Chr7:102441695-102469771 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28077 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    R1, RIR1, RR1
  • Links
    NCBI Gene ID: 6240
    neXtProt AC: NX_P23921

  • Chr Location
    11p15.4; chr11:4094561-4138881 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Rrm1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060506 VEGA Gene Model | MGI Sequence Detail 28077 C57BL/6J ±  kb
transcript OTTMUST00000148020 VEGA | MGI Sequence Detail 3997 Not Applicable  
polypeptide OTTMUSP00000076994 VEGA | MGI Sequence Detail 792 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    527 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014305 ribonucleoside-diphosphate reductase large subunit
  • EC
  • InterPro Domains
    IPR005144 ATP-cone domain
    IPR013346 Ribonucleotide reductase, class I , alpha subunit
    IPR000788 Ribonucleotide reductase large subunit, C-terminal
    IPR013509 Ribonucleotide reductase large subunit, N-terminal
    IPR008926 Ribonucleotide reductase R1 subunit, N-terminal
Molecular
Reagents
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  • All nucleic 28
    Genomic 8
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14209
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:7868 Caras IW, et al., Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem. 1985 Jun 10;260(11):7015-22
  • Latest
    J:228239 Specks J, et al., A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015 Sep 1;35(17):2910-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory