About   Help   FAQ
Rps6 Gene Detail
Summary
  • Symbol
    Rps6
  • Name
    ribosomal protein S6
  • Synonyms
    S6R
  • Feature Type
    protein coding gene
  • IDs
    MGI:98159
    NCBI Gene: 20104
Location & Maps
more
  • Sequence Map
    Chr4:86854660-86857412 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2753 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 40.69 cM, cytoband C3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RPS6, ribosomal protein S6
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RPS6, ribosomal protein S6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    S6
  • Links
    NCBI Gene ID: 6194
    neXtProt AC: NX_P62753

  • Chr Location
    9p22.1; chr9:19376256-19380237 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Rps6
  • Incidental Mutations
Mice with an inducible, liver-specific null mutation exhibit failure of liver regeneration and an absence of 40S ribosomes in hepatocytes. Mice with a mutation where serines are unphosphorylatable exhibit hypoinsulinemia, impaired glucose tolerance, and smaller MEFs and beta cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007781 VEGA Gene Model | MGI Sequence Detail 2753 C57BL/6J ±  kb
transcript OTTMUST00000017760 VEGA | MGI Sequence Detail 878 Not Applicable  
polypeptide OTTMUSP00000008183 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 2
    cDNA 29
    Primer pair 1

    Microarray probesets 12
Other
Accession IDs
less
MGD-MRK-14186
References
more
  • Summaries
    All 99
    Developmental Gene Expression 50
    Gene Ontology 13
    Phenotypes 18
  • Earliest
    J:8776 Lalanne JL, et al., Complete sequence of mouse S6 ribosomal protein. Nucleic Acids Res. 1987 Jun 25;15(12):4990
  • Latest
    J:230653 Grego-Bessa J, et al., The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory