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Rps12 Gene Detail
Summary
  • Symbol
    Rps12
  • Name
    ribosomal protein S12
  • Feature Type
    protein coding gene
  • IDs
    MGI:98105
    NCBI Gene: 20042
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:23661081-23663173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 11.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    28
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98105
 protein coding gene Chr10:23661042-23664297 (-)
129S1/SvImJ ENSMUSG00200008361
 protein coding gene Chr10:20499177-20501269 (-)
129S1/SvImJ ENSMUSG00200014657
 protein coding gene Chr19:56018362-56018865 (+)
A/J ENSMUSG00195013939
 protein coding gene Chr10:20820407-20822499 (-)
AKR/J ENSMUSG00220010582
 protein coding gene Chr10:20500750-20502842 (-)
BALB/cJ ENSMUSG00180016714
 protein coding gene Chr19:56416813-56417395 (+)
BALB/cJ ENSMUSG00180017494
 protein coding gene Chr10:20943664-20945756 (-)
C3H/HeJ ENSMUSG00175023381
 protein coding gene Chr10:20617601-20619693 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0015171
 protein coding gene Chr10:19815471-19817524 (-)
CAST/EiJ ENSTCUG00005012934
 protein coding gene Chr10:20218773-20220918 (-)
CBA/J ENSMUSG00210023300
 protein coding gene Chr10:20565260-20567352 (-)
CBA/J ENSMUSG00210032058
 protein coding gene Chr8:118592003-118592601 (+)
DBA/2J ENSMUSG00185033348
 protein coding gene Chr8:124696939-124697541 (+)
DBA/2J ENSMUSG00185006934
 protein coding gene Chr10:20735217-20737309 (-)
FVB/NJ ENSMUSG00205008733
 protein coding gene Chr10:20762720-20764812 (-)
FVB/NJ ENSMUSG00205003179
 protein coding gene Chr19:55448917-55449416 (+)
FVB/NJ ENSMUSG00205024452
 protein coding gene Chr8:117558236-117558834 (+)
JF1/MsJ ENSUMUG00000010670
 protein coding gene Chr10:20542091-20544236 (-)
LP/J ENSMUSG00230009183
 protein coding gene Chr10:22533814-22535906 (-)
LP/J ENSMUSG00230026820
 protein coding gene Chr19:57300745-57301248 (+)
NOD/ShiLtJ ENSMUSG00190018007
 protein coding gene Chr8:118692485-118693028 (+)
NOD/ShiLtJ ENSMUSG00190015053
 protein coding gene Chr10:20872527-20874618 (-)
NOD/ShiLtJ ENSMUSG00190012314
 protein coding gene Chr19:55984549-55985048 (+)
NZO/HlLtJ ENSMUSG00225029719
 protein coding gene Chr10:26788128-26790220 (-)
NZO/HlLtJ ENSMUSG00225041653
 protein coding gene Chr8:131697411-131698013 (+)
PWK/PhJ ENSLUMG00010009689
 protein coding gene Chr10:20439142-20441287 (-)
SPRET/EiJ ENSMSPG00010014238
 protein coding gene Chr10:21138954-21141074 (-)
WSB/EiJ ENSIUOG00005020743
 protein coding gene Chr10:20123215-20125306 (-)



Homology
more
  • Human Ortholog
    RPS12, ribosomal protein S12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS12, ribosomal protein S12
  • Synonyms
    eS12, S12
  • Links
    NCBI Gene ID: 6206
    UniProt: P25398

  • Chr Location
    6q23.2; chr6:132814557-132817577 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective erythropoiesis and hematopoietic stem cell maintenance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061983 Ensembl Gene Model | MGI Sequence Detail 2093 C57BL/6J ±  kb
    transcript ENSMUST00000218221 Ensembl | MGI Sequence Detail 460 Not Applicable  
    polypeptide ENSMUSP00000151586 Ensembl | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 19
    Other
    Accession IDs
    less
    MGD-MRK-14131
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:338970 Folgado-Marco V, et al., Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance. Elife. 2023 Jun 5;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory