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Pdc Gene Detail
Summary
  • Symbol
    Pdc
  • Name
    phosducin
  • Synonyms
    Pdc, Rpr1, Rpr-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98090
    NCBI Gene: 20028
  • Gene Overview
    MyGene.info: PDC
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:150319417-150333906 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 63.84 cM
  • Mapping Data
    6 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98090
protein coding gene Chr1:150319417-150333906 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016574
protein coding gene Chr1:154968000-154984308 (+)
A/J MGP_AJ_G0016556
protein coding gene Chr1:148721386-148735850 (+)
AKR/J MGP_AKRJ_G0016521
protein coding gene Chr1:153276223-153292939 (+)
BALB/cJ MGP_BALBcJ_G0016516
protein coding gene Chr1:149253960-149268706 (+)
C3H/HeJ MGP_C3HHeJ_G0016341
protein coding gene Chr1:153447717-153462177 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016977
protein coding gene Chr1:160339589-160354350 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014686
protein coding gene Chr1:141085319-141101093 (+)
CAST/EiJ MGP_CASTEiJ_G0015920
protein coding gene Chr1:152843552-152861489 (+)
CBA/J MGP_CBAJ_G0016315
protein coding gene Chr1:165996767-166014397 (+)
DBA/2J MGP_DBA2J_G0016421
protein coding gene Chr1:147772068-147786691 (+)
FVB/NJ MGP_FVBNJ_G0016419
protein coding gene Chr1:146198856-146213338 (+)
LP/J MGP_LPJ_G0016492
protein coding gene Chr1:156002555-156020133 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016445
protein coding gene Chr1:173697466-173716888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017013
protein coding gene Chr1:153074663-153089712 (+)
PWK/PhJ MGP_PWKPhJ_G0015706
protein coding gene Chr1:146695489-146710517 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015494
protein coding gene Chr1:151881899-151899533 (+)
WSB/EiJ MGP_WSBEiJ_G0015983
protein coding gene Chr1:153162428-153177546 (+)



Homology
more
  • Human Ortholog
    PDC, phosducin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PDC, phosducin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEKA, PHD, PhLOP, PhLP
  • Links
    NCBI Gene ID: 5132
    neXtProt AC: NX_P20941
    UniProt: P20941

  • Chr Location
    1q31.1; chr1:186443566-186461108 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1950
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PDC
  • Protein SuperFamily
  • Gene Tree
    Pdc
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20028 NCBI Gene Model | MGI Sequence Detail 14490 C57BL/6J ±  kb
    transcript NM_001159730 RefSeq | MGI Sequence Detail 1263 C57BL/6  
    polypeptide Q9QW08 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 108
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
    • Latest
      J:264207 Rodgers HM, et al., The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev. 2018 Jun;151:18-29

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory