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Pdc
Gene Detail
 Symbol
Name
ID
Pdc
phosducin
MGI:98090
STS D1Mit200
Synonyms Pdc, Rpr1, Rpr-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
63.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:150319417-150333905 bp, + strand
From Ensembl annotation of GRCm38

  14489 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: phosducin
Gene Tree: Pdc

Human
homologs
Human Homolog PDC, phosducin
NCBI Gene ID 5132
neXtProt AC  NX_P20941
Human Synonyms  MEKA, PHD, PhLOP, PhLP
Human Chr (Location)  1q25.2; chr1:186443566-186461108 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.
 
Interactions
Pdc interacts with 86 markers (Mir16-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process response to stimulus, visual perception
Component cell projection, cilium, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (70)    Tissues (14)    Images (23)
Theiler Stages: 16, 23
Assay TypeResults
RNA in situ 69
RT-PCR 1
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(109) Genomic(1) cDNA(107) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000006007 (Evidence)
Entrez Gene20028 (Evidence)
UniGene440883
DFCITC1578164, TC1602541, TC1604085
DoTSDT.55241251, DT.94171586
NIA Mouse Gene IndexU000901
Consensus CDS ProjectCCDS15354.1
International Mouse Knockout Project StatusPdc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006007 Ensembl Gene Model | MGI Sequence Detail 14489 C57BL/6J ±  kb
transcript ENSMUST00000165062 Ensembl | MGI Sequence Detail 1246 Not Applicable 
polypeptide ENSMUSP00000131631 Ensembl | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(1)
Polymorphisms RFLP(4) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001200 Phosducin
InterPro IPR023196 Phosducin N-terminal domain
InterPro IPR024253 Phosducin, thioredoxin-like domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000012450 phosducin
References (Earliest) J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
(Latest) J:196834 Belcastro M, et al., Phosphorylation of phosducin accelerates rod recovery from transducin translocation. Invest Ophthalmol Vis Sci. 2012 May;53(6):3084-91
All references(36)
Other
accession IDs
MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory