About   Help   FAQ
Pdc
Gene Detail
Symbol

Name
ID
Pdc
phosducin
MGI:98090
STS
Synonyms
Pdc, Rpr1, Rpr-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
63.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:150319417-150333906 bp, + strand
From VEGA annotation of GRCm38

  14490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PDC
Protein SuperFamily: phosducin
Gene Tree: Pdc

Human
homologs
PDC, phosducin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5132
neXtProt AC: NX_P20941

Human Synonyms: MEKA, PHD, PhLOP, PhLP

Human Chr (Location): 1q25.2; chr1:186443566-186461108 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.
 
Interactions
Pdc interacts with 86 markers (Mir16-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process response to stimulus, visual perception
Component cell projection, cilium, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (70)    Tissues (14)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
RT-PCR 1
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdc ; ZFIN pdca    NEW 
Molecular
reagents
All nucleic(109) Genomic(1) cDNA(107) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049379 (Evidence)
Ensembl Gene Model ENSMUSG00000006007 (Evidence)
Entrez Gene 20028 (Evidence)
UniGene 440883
DFCI TC1578164, TC1602541, TC1604085
DoTS DT.55241251, DT.94171586
NIA Mouse Gene Index U000901
Consensus CDS Project CCDS15354.1
International Mouse Phenotyping Consortium Status Pdc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049379 VEGA Gene Model | MGI Sequence Detail 14490 C57BL/6J ±  kb
transcript OTTMUST00000125866 VEGA | MGI Sequence Detail 1235 Not Applicable 
polypeptide OTTMUSP00000068120 VEGA | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001200 Phosducin
InterPro IPR023196 Phosducin N-terminal domain
InterPro IPR024253 Phosducin, thioredoxin-like domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000012450 phosducin
References
(Earliest) J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
(Latest) J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
All references(36)
Other
accession IDs
MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory