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Polr2a Gene Detail
Summary
  • Symbol
    Polr2a
  • Name
    polymerase (RNA) II (DNA directed) polypeptide A
  • Synonyms
    220kDa, Rpo2-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98086
    NCBI Gene: 20020
  • Gene Overview
    MyGene.info: POLR2A
Location & Maps
more
  • Sequence Map
    Chr11:69733997-69758637 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24641 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B1-C
  • Mapping Data
    10 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    POLR2A, polymerase (RNA) II subunit A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POLR2A, polymerase (RNA) II subunit A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hRPB220, hsRPB1, POLR2, POLRA, RPB1, RPBh1, RpIILS, RPO2, RPOL2
  • Links
    NCBI Gene ID: 5430
    neXtProt AC: NX_P24928

  • Chr Location
    17p13.1; chr17:7484379-7514618 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 5 alleles in 4 genetic backgrounds
    69 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    9
  • Genomic Mutations
    2 involving Polr2a
  • Incidental Mutations
Homozygotes for a reporter allele show prenatal lethality. Homozygotes for a small deletion in the C-terminal domain are viable, fertile and developmentally normal. Homozygotes for a larger deletion show reduced fetal size and partial postnatal lethality; survivors are small but otherwise normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006003 VEGA Gene Model | MGI Sequence Detail 24641 C57BL/6J ±  kb
transcript OTTMUST00000013440 VEGA | MGI Sequence Detail 6740 Not Applicable  
polypeptide OTTMUSP00000006224 VEGA | MGI Sequence Detail 1970 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    122 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 150
    Genomic 17
    cDNA 129
    Primer pair 1
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14111
References
more
  • Summaries
    All 108
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 17
    Phenotypes 51
  • Earliest
    J:8443 Pravtcheva D, et al., Chromosomal assignment of gene encoding the largest subunit of RNA polymerase II in the mouse. Somat Cell Mol Genet. 1986 Sep;12(5):523-8
  • Latest
    J:231359 Wei H, et al., Unique subcellular distribution of RPB1 with a phosphorylated C-terminal domain (CTD) in mouse oocytes during meiotic division and its relationship with chromosome separation. J Reprod Dev. 2015;61(6):541-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory