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Polr2a
Gene Detail
Symbol

Name
ID
Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
MGI:98086
STS
Synonyms
220kDa, Rpo2-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.86 cM, cytoband B1-C
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:69733997-69758637 bp, - strand
From VEGA annotation of GRCm38

  24641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POLR2A
Protein SuperFamily: DNA-directed RNA polymerase II largest subunit
Gene Tree: Polr2a

Human
homologs
POLR2A, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5430
neXtProt AC: NX_P24928

Human Synonyms: hRPB220, hsRPB1, POLR2, POLRA, RPB1, RPBh1, RpIILS, RPO2, RPOL2

Human Chr (Location): 17p13.1; chr17:7484379-7514618 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(5) Targeted(9)
Genomic Mutations involving Polr2a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a reporter allele show prenatal lethality. Homozygotes for a small deletion in the C-terminal domain are viable, fertile and developmentally normal. Homozygotes for a larger deletion show reduced fetal size and partial postnatal lethality; survivors are small but otherwise normal.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Polr2a interacts with 88 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process positive regulation of RNA splicing, transcription, DNA-templated, ...
Component DNA-directed RNA polymerase II, core complex, nuclear euchromatin, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (111)    Tissues (108)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 110
RT-PCR 1
cDNA source data(128)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase polr2a ; ZFIN polr2a    NEW 
Molecular
reagents
All nucleic(150) Genomic(17) cDNA(129) Primer pair(1) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006003 (Evidence)
Ensembl Gene Model ENSMUSG00000005198 (Evidence)
Entrez Gene 20020 (Evidence)
UniGene 16533
DFCI TC1579974, TC1602510, TC1683606, TC1716866
DoTS DT.101347659, DT.101394669, DT.492996, DT.94271459
NIA Mouse Gene Index U032977
EC 2.7.7.6
Consensus CDS Project CCDS36196.1, CCDS70217.1
International Mouse Phenotyping Consortium Status Polr2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006003 VEGA Gene Model | MGI Sequence Detail 24641 C57BL/6J ±  kb
transcript OTTMUST00000013440 VEGA | MGI Sequence Detail 6740 Not Applicable 
polypeptide OTTMUSP00000006224 VEGA | MGI Sequence Detail 1970 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(3) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000722 RNA polymerase, alpha subunit
InterPro IPR000684 RNA polymerase II, heptapeptide repeat, eukaryotic
InterPro IPR006592 RNA polymerase, N-terminal
InterPro IPR007080 RNA polymerase Rpb1, domain 1
InterPro IPR007066 RNA polymerase Rpb1, domain 3
InterPro IPR007083 RNA polymerase Rpb1, domain 4
InterPro IPR007081 RNA polymerase Rpb1, domain 5
InterPro IPR007075 RNA polymerase Rpb1, domain 6
InterPro IPR007073 RNA polymerase Rpb1, domain 7
Protein Ontology PR:000012987 DNA-directed RNA polymerase II subunit RPB1
References
(Earliest) J:8443 Pravtcheva D, et al., Chromosomal assignment of gene encoding the largest subunit of RNA polymerase II in the mouse. Somat Cell Mol Genet. 1986 Sep;12(5):523-8
(Latest) J:217204 Ambrogio C, et al., Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Res. 2014 Nov 1;74(21):5978-88
All references(104)
Other
accession IDs
MGD-MRK-14111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory