Rpl18 MGI Mouse Gene Detail - MGI:98003

Symbol

Rpl18
Name

ribosomal protein L18
Synonyms

L18, Rpl18a

Feature Type

protein coding gene
IDs

MGI:98003
NCBI Gene: 19899
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:45364891-45370255 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.45 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98003	protein coding gene	Chr7:45364881-45370260 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032243	protein coding gene	Chr7:46024010-46031549 (+)
A/J	MGP_AJ_G0032222	protein coding gene	Chr7:45114107-45116812 (+)
AKR/J	MGP_AKRJ_G0032158	protein coding gene	Chr7:46366141-46371376 (+)
BALB/cJ	MGP_BALBcJ_G0032234	protein coding gene	Chr7:45106175-45113135 (+)
C3H/HeJ	MGP_C3HHeJ_G0031949	protein coding gene	Chr7:46860460-46863157 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032726	protein coding gene	Chr7:48274636-48281602 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029740	protein coding gene	Chr7:47668106-47670783 (+)
CAST/EiJ	MGP_CASTEiJ_G0024437	protein coding gene	Chr19:52110363-52111709 (+)
CBA/J	MGP_CBAJ_G0031914	protein coding gene	Chr7:49887050-49890561 (+)
DBA/2J	MGP_DBA2J_G0032072	protein coding gene	Chr7:44794706-44797403 (+)
FVB/NJ	MGP_FVBNJ_G0032023	protein coding gene	Chr7:44567426-44570124 (+)
LP/J	MGP_LPJ_G0032150	protein coding gene	Chr7:46728686-46737087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032060	protein coding gene	Chr7:48565361-48572693 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032742	protein coding gene	Chr7:45574755-45583607 (+)
PWK/PhJ	MGP_PWKPhJ_G0031000	protein coding gene	Chr7:38161674-38165742 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030838	protein coding gene	Chr7:33609618-33614297 (+)
WSB/EiJ	MGP_WSBEiJ_G0031395	protein coding gene	Chr7:46079037-46086635 (+)

Human Ortholog

RPL18, ribosomal protein L18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL18, ribosomal protein L18
Synonyms

DBA18, eL18, L18
Links

HGNC:10310

NCBI Gene ID: 6141

neXtProt AC: NX_Q07020

UniProt: Q07020
Chr Location

19q13.33; chr19:48615328-48619184 (-) GRCh38

MGI Vertebrate Homology

Rpl18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL18
Gene Tree

Rpl18

Diseases

1 with human RPL18 associations

				Human Disease	Mouse Models
				Diamond-Blackfan anemia 18 IDs Diamond-Blackfan anemia 18 DOID:0111896 OMIM:618310

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

11
Gene trapped

11
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl18

ZFIN rpl18

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All Sequences

74
RefSeq

8
UniProt

10
CCDS

CCDS39958.1

Ensembl

ENSMUSG00000059070 (Evidence)
NCBI Gene

19899

			Length	Strain/Species	Flank
genomic	19899	NCBI Gene Model \| MGI Sequence Detail	5365	C57BL/6J	± kb
transcript	NM_009077	RefSeq \| MGI Sequence Detail	646	C57BL/6
polypeptide	P35980	UniProt \| EBI \| MGI Sequence Detail	188	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000014197 large ribosomal subunit protein eL18

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR000039 Large ribosomal subunit protein eL18

IPR021132 Large ribosomal subunit protein eL18, conserved site

IPR021131 Large ribosomal subunit protein uL15/eL18

IPR036227 Large ribosomal subunit protein uL15/eL18 superfamily

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

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MGD-MRK-14026

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 3
Earliest

J:31514 Meyuhas O, et al., Construction and identification of cDNA clones for mouse ribosomal proteins: application for the study of r-protein gene expression. Gene. 1980 Jul;10(2):113-29
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2253	Chr7:45364302-45364314 (+)	-583 bp
Tssr2254	Chr7:45364822-45364844 (+)	-58 bp
Tssr66626	Chr7:45364937-45364958 (+)	57 bp
Tssr66627	Chr7:45367442-45367448 (+)	2,554 bp
Tssr66628	Chr7:45367459-45367472 (+)	2,575 bp
Tssr66629	Chr7:45367482-45367535 (+)	2,618 bp
Tssr66630	Chr7:45367545-45367571 (+)	2,667 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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