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Rln1 Gene Detail
Summary
  • Symbol
    Rln1
  • Name
    relaxin 1
  • Synonyms
    rlx
  • Feature Type
    protein coding gene
  • IDs
    MGI:97931
    NCBI Gene: 19773
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29331755-29334670 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 23.83 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97931
protein coding gene Chr19:29331170-29334670 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025020
protein coding gene Chr19:27782895-27786374 (-)
A/J MGP_AJ_G0024997
protein coding gene Chr19:26383350-26386850 (-)
AKR/J MGP_AKRJ_G0024965
protein coding gene Chr19:27339056-27342560 (-)
BALB/cJ MGP_BALBcJ_G0024996
protein coding gene Chr19:26432813-26436313 (-)
C3H/HeJ MGP_C3HHeJ_G0024752
protein coding gene Chr19:27316889-27320389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025437
protein coding gene Chr19:28554438-28557938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022856
protein coding gene Chr19:26357188-26360711 (-)
CAST/EiJ MGP_CASTEiJ_G0024222
protein coding gene Chr19:27142870-27146370 (-)
CBA/J MGP_CBAJ_G0024730
protein coding gene Chr19:29905098-29908598 (-)
DBA/2J MGP_DBA2J_G0024862
protein coding gene Chr19:26341267-26344639 (-)
FVB/NJ MGP_FVBNJ_G0024824
protein coding gene Chr19:26198280-26201780 (-)
LP/J MGP_LPJ_G0024947
protein coding gene Chr19:27785322-27788823 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024851
protein coding gene Chr19:29847493-29850993 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025492
protein coding gene Chr19:27360277-27363777 (-)
PWK/PhJ MGP_PWKPhJ_G0023970
protein coding gene Chr19:26014823-26018379 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023774
protein coding gene Chr19:26632568-26636074 (-)
WSB/EiJ MGP_WSBEiJ_G0024289
protein coding gene Chr19:27406775-27410275 (-)



Homology
more
  • Human Ortholog
    RLN1, relaxin 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    RLN1, relaxin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA12D24.3.1, bA12D24.3.2, H1, H1RLX, RLXH1
  • Links
    NCBI Gene ID: 6013
    neXtProt AC: NX_P04808
    UniProt: P04808

  • Chr Location
    9p24.1; chr9:5306937-5339883 (-)  GRCh38.p7

  • Human Ortholog
    RLN2, relaxin 2
    Orthology source: HGNC
  • Synonyms
    bA12D24.1.1, bA12D24.1.2, H2, H2-RLX, RLXH2
  • Links
    NCBI Gene ID: 6019
    neXtProt AC: NX_P04090
    UniProt: P04090

  • Chr Location
    9p24.1; chr9:5299864-5306134 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus is compatible with fertility but not normal mammary gland development. Postpartum, homozygous mutant females exhibit slight nipples that are insufficient for suckling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19773 NCBI Gene Model | MGI Sequence Detail 2916 C57BL/6J ±  kb
    transcript NM_011272 RefSeq | MGI Sequence Detail 697 Not Specified  
    polypeptide P47932 UniProt | EBI | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-13897
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:605 Fowler KJ, et al., The relaxin gene is located on chromosome 19 in the mouse. FEBS Lett. 1991 Nov 4;292(1-2):183-6
    • Latest
      J:277381 Bai M, et al., Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biol. 2019 Jul;17(7):e3000350

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/21/2020
    MGI 6.14
    The Jackson Laboratory