Rln1 MGI Mouse Gene Detail - MGI:97931

Symbol

Rln1
Name

relaxin 1
Synonyms

rlx

Feature Type

protein coding gene
IDs

MGI:97931
NCBI Gene: 19773
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:29309155-29312070 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 23.83 cM
Mapping Data

9 experiments

SNPs within 2kb

11 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97931	protein coding gene	Chr19:29308570-29312070 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025020	protein coding gene	Chr19:27782895-27786374 (-)
A/J	MGP_AJ_G0024997	protein coding gene	Chr19:26383350-26386850 (-)
AKR/J	MGP_AKRJ_G0024965	protein coding gene	Chr19:27339056-27342560 (-)
BALB/cJ	MGP_BALBcJ_G0024996	protein coding gene	Chr19:26432813-26436313 (-)
C3H/HeJ	MGP_C3HHeJ_G0024752	protein coding gene	Chr19:27316889-27320389 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025437	protein coding gene	Chr19:28554438-28557938 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022856	protein coding gene	Chr19:26357188-26360711 (-)
CAST/EiJ	MGP_CASTEiJ_G0024222	protein coding gene	Chr19:27142870-27146370 (-)
CBA/J	MGP_CBAJ_G0024730	protein coding gene	Chr19:29905098-29908598 (-)
DBA/2J	MGP_DBA2J_G0024862	protein coding gene	Chr19:26341267-26344639 (-)
FVB/NJ	MGP_FVBNJ_G0024824	protein coding gene	Chr19:26198280-26201780 (-)
LP/J	MGP_LPJ_G0024947	protein coding gene	Chr19:27785322-27788823 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024851	protein coding gene	Chr19:29847493-29850993 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025492	protein coding gene	Chr19:27360277-27363777 (-)
PWK/PhJ	MGP_PWKPhJ_G0023970	protein coding gene	Chr19:26014823-26018379 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023774	protein coding gene	Chr19:26632568-26636074 (-)
WSB/EiJ	MGP_WSBEiJ_G0024289	protein coding gene	Chr19:27406775-27410275 (-)

Human Ortholog

RLN1, relaxin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RLN1, relaxin 1
Synonyms

bA12D24.3.1, bA12D24.3.2, H1, H1RLX, RLXH1
Links

HGNC:10026

NCBI Gene ID: 6013

neXtProt AC: NX_P04808

UniProt: P04808
Chr Location

9p24.1; chr9:5334930-5340916 (-) GRCh38

Human Ortholog

RLN2, relaxin 2
Synonyms

bA12D24.1.1, bA12D24.1.2, H2, H2-RLX, RLXH2
Links

HGNC:10027

NCBI Gene ID: 6019

neXtProt AC: NX_P04090

UniProt: P04090
Chr Location

9p24.1; chr9:5299864-5339326 (-) GRCh38

MGI Vertebrate Homology

Rln1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RLN1, RLN2
Gene Tree

Rln1

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

3 involving Rln1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this locus is compatible with fertility but not normal mammary gland development. Postpartum, homozygous mutant females exhibit slight nipples that are insufficient for suckling.

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All GO Annotations

15
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

924
Tissues

33
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

4
CCDS

CCDS29733.1

Ensembl

ENSMUSG00000039097 (Evidence)
NCBI Gene

19773

			Length	Strain/Species	Flank
genomic	19773	NCBI Gene Model \| MGI Sequence Detail	2916	C57BL/6J	± kb
transcript	NM_011272	RefSeq \| MGI Sequence Detail	697	Not Specified
polypeptide	P47932	UniProt \| EBI \| MGI Sequence Detail	185	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000026014 prorelaxin H1

(term hierarchy)
InterPro Domains

IPR016179 Insulin-like

IPR036438 Insulin-like superfamily

IPR022421 Relaxin

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All nucleic 14

cDNA 13

Other 1

Microarray probesets 1

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MGD-MRK-13897

Summaries

All 72

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 34
Earliest

J:605 Fowler KJ, et al., The relaxin gene is located on chromosome 19 in the mouse. FEBS Lett. 1991 Nov 4;292(1-2):183-6
Latest

J:277381 Bai M, et al., Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biol. 2019 Jul;17(7):e3000350

TSS for Rln1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158752	Chr19:29312046-29312052 (-)	21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23