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Rnase1
Gene Detail
Symbol

Name
ID
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
MGI:97919
Synonyms
Rib1, Rib-1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.40 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr14:51145002-51146767 bp, - strand
From NCBI annotation of GRCm38

  1766 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7919  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

HCOP human homology predictions: RNASE1
Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Rnase1

Human
homologs
RNASE1, ribonuclease, RNase A family, 1 (pancreatic)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6035
neXtProt AC: NX_P07998

Human Synonyms: RAC1, RIB1, RNS1

Human Chr (Location): 14q11.2; chr14:20801356-20802877 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
Interactions
Rnase1 interacts with 90 markers (Mir18, Mir18b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process RNA phosphodiester bond hydrolysis, endonucleolytic
Component extracellular exosome, extracellular region
Function endonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (49)    Tissues (48)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 49
cDNA source data(138)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(145) Genomic(3) cDNA(140) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035896 (Evidence)
Entrez Gene 19752 (Evidence)
UniGene 235538
DFCI TC1572734
DoTS DT.40158107
NIA Mouse Gene Index U035522
EC 3.1.27.5
PDB 3TSR
Consensus CDS Project CCDS27038.1
International Mouse Phenotyping Consortium Status Rnase1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19752 NCBI Gene Model | MGI Sequence Detail 1766 C57BL/6J ±  kb
transcript NM_011271 RefSeq | MGI Sequence Detail 977 C57BL/6 
polypeptide P00683 UniProt | EBI | MGI Sequence Detail 149 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000014042 ribonuclease pancreatic
Graphical View of Protein Domain Structure
References
(Earliest) J:8319 Elliott RW, et al., Assignment of pancreatic ribonuclease gene to mouse chromosome 14. Cytogenet Cell Genet. 1986;42(1-2):110-2
(Latest) J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
All references(49)
Other
accession IDs
MGD-MRK-13876, MGD-MRK-13877, MGI:2145673

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory